product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein
catalog :
326-FS-050
quantity :
50 ug
price :
369 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Tyrinova T, Leplina O, Mishinov S, Tikhonova M, Dolgova E, Proskurina A, et al. Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells. Int J Mol Sci. 2020;21: pubmed publisher
Dodi A, Ajayi I, Chang C, Beard M, Ashley S, Huang S, et al. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respir Res. 2018;19:91 pubmed publisher
Juang S, Wei S, Hung Y, Hsu C, Yang D, Liu K, et al. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. J Interferon Cytokine Res. 2004;24:231-43 pubmed
Ryon J, Moss W, Monze M, Griffin D. Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles. Clin Diagn Lab Immunol. 2002;9:994-1003 pubmed
product information
brand :
R&D Systems
master code :
326-FS
SKU :
326-FS-050
product name :
Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein
description :
The Fas/TNFRSF6/CD95 Fc Chimera Protein from 326-FS-050 is derived from NS0-derived Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein. The Fas/TNFRSF6/CD95 Fc Chimera Protein has been validated for the following applications: Q5T9P3.
target :
Fas/TNFRSF6/CD95
category :
Proteins and Enzymes
unit sizes :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
45 kDa (monomer)
gene symbol :
FAS
details of functionality :
Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. Cheng, J. et al . (1994) Science 263 :1759. The ED50 for this effect is 0.01-0.04 µg/mL in the presence of 2 ng/mL recombinant human Fas Ligand.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q5T9P3
applications :
Bioactivity
extended description :
New rhFas! HEK293 expressed; ~2 fold better activity; Lower endotoxin specification; No His tag!
source :
NS0-derived Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein
USD :
369 USD
product details :
New rhFas! HEK293 expressed; ~2 fold better activity; Lower endotoxin specification; No His tag!
alt names :
Apo-1, Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1, APT1FASTM, CD95, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.