Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF | R&D Systems 326-FS-050/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF

catalog :

326-FS-050/CF

quantity :

50 ug

price :

431 USD

citations: 6

Reference
Belkahla S, Brualla J, Fayd Herbe De Maudave A, Falvo P, Allende Vega N, Constantinides M, et al. The metabolism of cells regulates their sensitivity to NK cells depending on p53 status. Sci Rep. 2022;12:3234 pubmed publisher
Tyrinova T, Leplina O, Mishinov S, Tikhonova M, Dolgova E, Proskurina A, et al. Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells. Int J Mol Sci. 2020;21: pubmed publisher
Dodi A, Ajayi I, Chang C, Beard M, Ashley S, Huang S, et al. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respir Res. 2018;19:91 pubmed publisher
Hu P, Han Z, Couvillon A, Kaufman R, Exton J. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol. 2006;26:3071-84 pubmed
Juang S, Wei S, Hung Y, Hsu C, Yang D, Liu K, et al. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. J Interferon Cytokine Res. 2004;24:231-43 pubmed
Ryon J, Moss W, Monze M, Griffin D. Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles. Clin Diagn Lab Immunol. 2002;9:994-1003 pubmed

product information

master code :

326-FS/CF

SKU :

326-FS-050/CF

product name :

Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Fas/TNFRSF6/CD95

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

45 kDa (monomer)

gene symbol :

FAS

details of functionality :

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. Cheng, J. etáal . (1994) Science 263 :1759. The ED50 for this effect is 0.01-0.04 ╡g/mL in the presence of 2 ng/mL recombinant human Fas Ligand.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q5T9P3

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Fas/TNFRSF6/CD95 protein Human Fas (Arg17 - Asn173) Accession # Q5T9P3 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

431 USD

alt names :

Apo-1, Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1, APT1FASTM, CD95, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.