Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF | R&D Systems 326-FS-050/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF

catalog :

326-FS-050/CF

quantity :

50 ug

price :

399 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Tyrinova T, Leplina O, Mishinov S, Tikhonova M, Dolgova E, Proskurina A, et al. Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells. Int J Mol Sci. 2020;21: pubmed publisher
Dodi A, Ajayi I, Chang C, Beard M, Ashley S, Huang S, et al. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respir Res. 2018;19:91 pubmed publisher
Juang S, Wei S, Hung Y, Hsu C, Yang D, Liu K, et al. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. J Interferon Cytokine Res. 2004;24:231-43 pubmed
Ryon J, Moss W, Monze M, Griffin D. Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles. Clin Diagn Lab Immunol. 2002;9:994-1003 pubmed

product information

brand :

R&D Systems

master code :

326-FS/CF

SKU :

326-FS-050/CF

product name :

Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF

unit size :

50 ug

target :

Fas/TNFRSF6/CD95

category :

Proteins and Enzymes

alt names :

Apo-1, Apo-1 antigen, apoptosis antigen 1, Apoptosis-mediating surface antigen FAS, APT1, APT1FASTM, CD95, CD95 antigen, CD95ALPS1A, Fas (TNF receptor superfamily, member 6), Fas AMA, Fas antigen, FAS1, FASLG receptor, TNFRSF6, TNFRSF6member 6, tumor necrosis factor receptor superfamily member 6

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

theoretical molecular weight :

45 kDa (monomer)

gene symbol :

FAS

details of functionality :

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. Cheng, J. et al . (1994) Science 263 :1759. The ED50 for this effect is 0.01-0.04 µg/mL in the presence of 2 ng/mL recombinant human Fas Ligand.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q5T9P3

applications :

Bioactivity

source :

NS0-derived Recombinant Human Fas/TNFRSF6/CD95 Fc Chimera Protein, CF

extended description :

New rh Fas! HEK293 expressed; ~2 fold better activity; Lower endotoxin specification; No His tag!

USD :

369

Jul-22 :

399 USD

product details :

New rh Fas! HEK293 expressed; ~2 fold better activity; Lower endotoxin specification; No His tag!

sizes available :

50 ug

more info or order :

R&D Systems product webpage