Recombinant Human CTLA-4 Fc Chimera His-tag Protein | R&D Systems 325-CT-200 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CTLA-4 Fc Chimera His-tag Protein

catalog :

325-CT-200

quantity :

200 ug

price :

438 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Hock B, MacPherson S, McKenzie J. Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLoS ONE. 2017;12:e0172858 pubmed publisher
Kowalczyk A, D Souza C, Zhang L. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol. 2014;44:1143-55 pubmed publisher
Steidl C, Shah S, Woolcock B, Rui L, Kawahara M, Farinha P, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 2011;471:377-81 pubmed publisher
Maniar A, Zhang X, Lin W, Gastman B, Pauza C, Strome S, et al. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood. 2010;116:1726-33 pubmed publisher
Shan M, Cheng H, Song L, Roberts L, Green L, Hacken Bitar J, et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med. 2009;1:4ra10 pubmed publisher
Sakthivel P, Shively V, Kakoulidou M, Pearce W, Lefvert A. The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. J Intern Med. 2007;261:399-407 pubmed
Lazetic S, Leong S, Chang J, Ong R, Dawes G, Punnonen J. Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells. J Biol Chem. 2002;277:38660-8 pubmed

image

image 1 :

Recombinant Human CTLA-4 Fc Chimera His-tag Protein Bioactivity

product information

brand :

R&D Systems

master code :

325-CT

SKU :

325-CT-200

product name :

Recombinant Human CTLA-4 Fc Chimera His-tag Protein

description :

The Recombinant Human CTLA-4 Fc Chimera His-tag Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human CTLA-4 Fc Chimera His-tag Protein has been validated for the following applications: Bioactivity.

target :

CTLA-4

category :

Proteins and Enzymes

sizes available :

200 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

theoretical molecular weight :

40 kDa (monomer)

gene symbol :

CTLA4

details of functionality :

Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Linsley, P.S. et al . (1991) J. Exp. Med. 174 :561. The ED50 for this effect is 0.1-0.4 µg/mL when stimulated with 1 µg/mL Recombinant Human B7-1/CD80 Fc Chimera (Catalog # 140-B1 ) in the presence of PHA.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6GR94

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human CTLA-4 Fc Chimera His-tag Protein

USD :

431

USD 2023 :

438 USD

alt names :

CD, CD152, CD152 antigen, CD152IDDM12, CD28, celiac disease 3, CELIAC3, CTLA4, CTLA-4, cytotoxic T-lymphocyte antigen 4, cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte-associated serine esterase-4, GRD4, GSE, ICOS, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage