Recombinant Human Integrin alpha 5 beta 1 Protein, CF | R&D Systems 3230-A5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha 5 beta 1 Protein, CF

catalog :

3230-A5

quantity :

50 ug

price :

369 USD

citations: 12

Reference
Rattila S, Dunk C, Im M, Grichenko O, Zhou Y, Yanez Mo M, et al. Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions. Cells. 2019;8: pubmed publisher
Kuninty P, Bansal R, de Geus S, Mardhian D, Schnittert J, van Baarlen J, et al. ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Sci Adv. 2019;5:eaax2770 pubmed publisher
Skoog E, Morikis V, Martin M, Foster G, Cai L, Hansen L, et al. CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding. MBio. 2018;9: pubmed publisher
Bönig T, Olbermann P, Bats S, Fischer W, Josenhans C. Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci Rep. 2016;6:38101 pubmed publisher
Brown A, Dysart M, Clarke K, STABENFELDT S, Barker T. Integrin Î±3Î²1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat. J Biol Chem. 2015;290:25534-47 pubmed publisher
Qiao L, Gao H, Zhang T, Jing L, Xiao C, Xiao Y, et al. Snail modulates the assembly of fibronectin via ?5 integrin for myocardial migration in zebrafish embryos. Sci Rep. 2014;4:4470 pubmed publisher
Stampolidis P, Ullrich A, Iacobelli S. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. Oncogene. 2015;34:39-52 pubmed publisher
Kwon I, Hong S, Kim Y, Nam H, Kang S, Yang S, et al. Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. PLoS ONE. 2013;8:e81165 pubmed publisher
Haidari M, Zhang W, Caivano A, Chen Z, Ganjehei L, Mortazavi A, et al. Integrin ?2?1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells. J Biol Chem. 2012;287:32981-92 pubmed
Shroff K, Kokkoli E. PEGylated liposomal doxorubicin targeted to ?5?1-expressing MDA-MB-231 breast cancer cells. Langmuir. 2012;28:4729-36 pubmed publisher
Martchenko M, Jeong S, Cohen S. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin. Proc Natl Acad Sci U S A. 2010;107:15583-8 pubmed publisher
Jullienne B, Vigant F, Muth E, Chaligne R, Bouquet C, Giraudier S, et al. Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid. Gene Ther. 2009;16:1405-15 pubmed publisher

product information

brand :

R&D Systems

master code :

3230-A5

SKU :

3230-A5-050

product name :

Recombinant Human Integrin alpha 5 beta 1 Protein, CF

description :

The Recombinant Human Integrin alpha 5 beta 1 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha 5 beta 1 Protein, CF has been validated for the following applications: Binding Activity.

target :

Integrin alpha 5 beta 1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-Citrate and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

105-150 kDa, reducing conditions

theoretical molecular weight :

108 kDa ( alpha 5 subunit), 82.3 kDa ( beta 1 subunit)

gene symbol :

ITGA5

details of functionality :

Measured by its binding ability in a functional ELISA. Recombinant Human Integrin alpha 5 beta 1 binds Bovine Fibronectin (Catalog # 1030-FN ) coated at 2 µg/mL with an apparent Kd 0.5 nM in the presence of 1 mM MnCl2.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

3230-A5

accessionNumbers :

P08648 (Integrin alpha 5) P05556 (Integrin beta 1)

applications :

Binding Activity

source :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha 5 beta 1 protein Human Integrin alpha 5 (Phe42-Tyr995) Accession # P08648 acidic tail Human Integrin beta 1 (Gln21-Asp728) Accession # P05556 basic tail N-terminus C-terminus

2020 USD :

369

2021 USD :

369 USD

alt names :

CD49 antigen-like family member E, CD49e, Fibronectin receptor subunit alpha, fibronectin receptor, alpha polypeptide, fibronectin receptor, alpha subunit, FNRA, integrin alpha-5, Integrin alpha-F, integrin, alpha 5 (fibronectin receptor, alpha polypeptide), ITGA5/SLC9B1 fusion, very late activation protein 5, alpha subunit, VLA-5, VLA5A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.