Recombinant Human Integrin alpha 5 beta 1 Protein, CF | R&D Systems 3230-A5-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha 5 beta 1 Protein, CF

catalog :

3230-A5-050

quantity :

50 ug

price :

458 USD

citations: 18

Reference
Ning K, Zou W, Xu P, Cheng F, Zhang E, Zhang Chen A, et al. Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors. Sci Adv. 2023;9:eade0869 pubmed publisher
Gerwin N, Scotti C, Halleux C, Fornaro M, Elliott J, Zhang Y, et al. Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial. Nat Med. 2022;28:2633-2645 pubmed publisher
Cegarra C, Cameron B, Chaves C, Dabdoubi T, Do T, Gen xea t B, et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLoS ONE. 2022;17:e0274667 pubmed publisher
Norris E, Pan X, Hocking D. Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist. bioRxiv. 2022;: pubmed publisher
Irie F, Tobisawa Y, Murao A, Yamamoto H, Ohyama C, Yamaguchi Y. The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites. J Biol Chem. 2021;296:100481 pubmed publisher
Rattila S, Dunk C, Im M, Grichenko O, Zhou Y, Yanez Mo M, et al. Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions. Cells. 2019;8: pubmed publisher
Kuninty P, Bansal R, de Geus S, Mardhian D, Schnittert J, van Baarlen J, et al. ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Sci Adv. 2019;5:eaax2770 pubmed publisher
Skoog E, Morikis V, Martin M, Foster G, Cai L, Hansen L, et al. CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding. MBio. 2018;9: pubmed publisher
Barbhuiya M, Mirando A, Simons B, Lemtiri Chlieh G, Green J, Popel A, et al. Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma. Oncotarget. 2017;8:101520-101534 pubmed publisher
Bönig T, Olbermann P, Bats S, Fischer W, Josenhans C. Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci Rep. 2016;6:38101 pubmed publisher
Brown A, Dysart M, Clarke K, STABENFELDT S, Barker T. Integrin Î±3Î²1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat. J Biol Chem. 2015;290:25534-47 pubmed publisher
Qiao L, Gao H, Zhang T, Jing L, Xiao C, Xiao Y, et al. Snail modulates the assembly of fibronectin via ?5 integrin for myocardial migration in zebrafish embryos. Sci Rep. 2014;4:4470 pubmed publisher
Stampolidis P, Ullrich A, Iacobelli S. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. Oncogene. 2015;34:39-52 pubmed publisher
Kwon I, Hong S, Kim Y, Nam H, Kang S, Yang S, et al. Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. PLoS ONE. 2013;8:e81165 pubmed publisher
Haidari M, Zhang W, Caivano A, Chen Z, Ganjehei L, Mortazavi A, et al. Integrin ?2?1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells. J Biol Chem. 2012;287:32981-92 pubmed
Shroff K, Kokkoli E. PEGylated liposomal doxorubicin targeted to ?5?1-expressing MDA-MB-231 breast cancer cells. Langmuir. 2012;28:4729-36 pubmed publisher
Martchenko M, Jeong S, Cohen S. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin. Proc Natl Acad Sci U S A. 2010;107:15583-8 pubmed publisher
Jullienne B, Vigant F, Muth E, Chaligne R, Bouquet C, Giraudier S, et al. Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid. Gene Ther. 2009;16:1405-15 pubmed publisher

product information

brand :

R&D Systems

MasterCode :

3230-A5

SKU :

3230-A5-050

product name :

Recombinant Human Integrin alpha 5 beta 1 Protein, CF

Description :

The Integrin alpha 5 beta 1 Protein from 3230-A5-050 is derived from CHO-derived Recombinant Human Integrin alpha 5 beta 1 Protein, CF. The Integrin alpha 5 beta 1 Protein has been validated for the following applications: P08648 (Integrin alpha 5) P05556 (Integrin beta 1).

target :

Integrin alpha 5 beta 1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-Citrate and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

105-150 kDa, reducing conditions

theoretical molecular weight :

108 kDa ( alpha 5 subunit), 82.3 kDa ( beta 1 subunit)

gene symbol :

ITGA5

details of functionality :

Measured by its binding ability in a functional ELISA. Recombinant Human Integrin alpha 5 beta 1 binds Bovine Fibronectin (Catalog # 1030-FN ) coated at 2 µg/mL with an apparent Kd 0.5 nM in the presence of 1 mM MnCl2.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P08648 (Integrin alpha 5) P05556 (Integrin beta 1)

applications :

Binding Activity

source :

CHO-derived Recombinant Human Integrin alpha 5 beta 1 Protein, CF

USD :

458 USD

alt names :

CD49 antigen-like family member E, CD49e, Fibronectin receptor subunit alpha, fibronectin receptor, alpha polypeptide, fibronectin receptor, alpha subunit, FNRA, integrin alpha-5, Integrin alpha-F, integrin, alpha 5 (fibronectin receptor, alpha polypeptide), ITGA5/SLC9B1 fusion, very late activation protein 5, alpha subunit, VLA-5, VLA5A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.