product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-2/BMP-7 Heterodimer Protein
catalog :
3229-BM-010
quantity :
10 ug
price :
564 USD
more info or order :
R&D Systems product webpage
citations: 17
Reference
Yang Y, Kim J, Xie J, Chaugule S, Lin C, Ma H, et al. Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery. Nat Commun. 2022;13:6175 pubmed publisher
Greenfeld H, Lin J, Mullins M. The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biol. 2021;19:e3001059 pubmed publisher
Kim J, Yang Y, Park K, Ge X, Xu R, Li N, et al. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020;11:2289 pubmed publisher
Krouwels A, Iljas J, Kragten A, Dhert W, Oner F, Tryfonidou M, et al. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. Int J Mol Sci. 2020;21: pubmed publisher
Ho W, Freem L, Zhao D, Painter K, Woolley T, Gaffney E, et al. Feather arrays are patterned by interacting signalling and cell density waves. PLoS Biol. 2019;17:e3000132 pubmed publisher
Tanis S, Köksal E, van Buggenum J, Mulder K. BLNCR is a long non-coding RNA adjacent to integrin beta-1 that is rapidly lost during epidermal progenitor cell differentiation. Sci Rep. 2019;9:31 pubmed publisher
El Naggar A, Clarkson P, Negri G, Turgu B, Zhang F, Anglesio M, et al. HACE1 is a potential tumor suppressor in osteosarcoma. Cell Death Dis. 2019;10:21 pubmed publisher
Tanis S, Jansen P, Zhou H, van Heeringen S, Vermeulen M, Kretz M, et al. Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation. Cell Rep. 2018;25:1292-1303.e5 pubmed publisher
Bi W, Liu Y, Guo J, Lin Z, Liu J, Zhou M, et al. All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci. 2018;8:48 pubmed publisher
Loozen L, Vandersteen A, Kragten A, Oner F, Dhert W, Kruyt M, et al. Bone formation by heterodimers through non-viral gene delivery of BMP-2/6 and BMP-2/7. Eur Cell Mater. 2018;35:195-208 pubmed publisher
Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, et al. Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage. Stem Cells Transl Med. 2017;6:490-501 pubmed publisher
Greenblatt M, Kim J, Oh H, Park K, Choo M, Sano Y, et al. p38α MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015;290:284-95 pubmed publisher
Ochiai Shino H, Kato H, Sawada T, Onodera S, Saito A, Takato T, et al. A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination. PLoS ONE. 2014;9:e99534 pubmed publisher
Goldie S, Mulder K, Tan D, Lyons S, Sims A, Watt F. FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis. Cancer Res. 2012;72:3424-36 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Little S, Mullins M. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol. 2009;11:637-43 pubmed publisher
Esterberg R, Delalande J, Fritz A. Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Development. 2008;135:3891-901 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
3229-BM
SKU :
3229-BM-010
product name :
Recombinant Human BMP-2/BMP-7 Heterodimer Protein
Description :
The Recombinant Human BMP-2/BMP-7 Heterodimer Protein from R&D Systems is derived from E. coli. The Recombinant Human BMP-2/BMP-7 Heterodimer Protein has been validated for the following applications: Bioactivity.
target :
BMP-2/BMP-7 Heterodimer
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as 0.2 µm filtered solution in 30%(v/v) Acetonitrile and 0.1%(v/v) TFA with 50 µg BSA per 1 µg as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
12.9 kDa (BMP-2), 15.8 kDa (BMP-7)
gene symbol :
BMP2
details of functionality :
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 15.0-120 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_001191 (BMP-2) NP_001710 (BMP-7)
applications :
Bioactivity
source :
E. coli-derived Recombinant Human BMP-2/BMP-7 Heterodimer Protein
USD :
564 USD
alt names :
BDA2, BDA2;BMP2A;Bone morphogenetic protein 2;SSFSC;SSFSC1, BMP2, BMP7, OP-1, SSFSC
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.