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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-9 Protein, CF
catalog :
3209-BP-010/CF
quantity :
10 ug
price :
493 USD
more info or order :
citations: 50
Reference
Park J, Koh E, Seo Y, Oh H, Byun J. BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells. Int J Mol Sci. 2023;24: pubmed publisher
Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, et al. Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models. Proc Natl Acad Sci U S A. 2023;120:e2213317120 pubmed publisher
Ivaldo C, Passalacqua M, Furfaro A, d Abramo C, Ruiz S, Chatterjee P, et al. Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10. Sci Rep. 2023;13:597 pubmed publisher
Shonibare Z, Monavarian M, O CONNELL K, Altomare D, Shelton A, Mehta S, et al. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep. 2022;40:111066 pubmed publisher
Marvin D, You L, Bornes L, Van Dinther M, Peters N, Dang H, et al. Dynamic Visualization of TGF-β/SMAD3 Transcriptional Responses in Single Living Cells. Cancers (Basel). 2022;14: pubmed publisher
Kawecki F, Jann J, Fortin M, Auger F, Faucheux N, Fradette J. Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction. Int J Mol Sci. 2022;23: pubmed publisher
Addante A, Gonz xe1 lez Corralejo C, Roncero C, Lazcanoiturburu N, Garc xed a S xe1 ez J, Herrera B, et al. BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells. Cells. 2022;11: pubmed publisher
Fujioka Kobayashi M, Marjanowski S, Kono M, Hino S, Saulacic N, Schaller B. Osteoinductive potential of recombinant BMP-9 in bone defects of mice treated with antiresorptive agents. Int J Oral Maxillofac Surg. 2022;51:566-575 pubmed publisher
Jiang Q, Li Q, Liu B, Li G, Riedemann G, Gaitantzi H, et al. BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization. Int Immunopharmacol. 2021;96:107591 pubmed publisher
Tao B, Kraehling J, Ghaffari S, Ramírez C, Lee S, Fowler J, et al. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. J Biol Chem. 2020;295:18179-18188 pubmed publisher
Alinejad Y, Lauzon M, Grenier G, Balg F, Faucheux N. Both Human Hematoma Punctured from Pelvic Fractures and Serum Increase Muscle Resident Stem Cells Response to BMP9: A Multivariate Statistical Approach. J Clin Med. 2020;9: pubmed publisher
Addante A, Roncero C, Lazcanoiturburu N, Méndez R, Almalé L, García Álvaro M, et al. A Signaling Crosstalk between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival. Cells. 2020;9: pubmed publisher
Wang X, Zong L, Wang W, Yang J, Xiang Y. CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway. J Cancer. 2020;11:272-283 pubmed publisher
Drouin G, Couture V, Lauzon M, Balg F, Faucheux N, Grenier G. Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells. Skelet Muscle. 2019;9:18 pubmed publisher
Cao X, Yakala G, van den Hil F, Cochrane A, Mummery C, Orlova V. Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives. Stem Cell Reports. 2019;12:1282-1297 pubmed publisher
Yu L, Dawson L, Yan M, Zimmel K, Lin Y, Dolan C, et al. BMP9 stimulates joint regeneration at digit amputation wounds in mice. Nat Commun. 2019;10:424 pubmed publisher
Subileau M, Merdzhanova G, Ciais D, Collin Faure V, Feige J, Bailly S, et al. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation. Stem Cell Reports. 2019;12:98-111 pubmed publisher
Tillet E, Ouarné M, Desroches Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963-10974 pubmed publisher
Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, et al. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. elife. 2018;7: pubmed publisher
Tian H, Huang J, Golzio C, Gao X, Hector Greene M, Katsanis N, et al. Endoglin interacts with VEGFR2 to promote angiogenesis. FASEB J. 2018;32:2934-2949 pubmed publisher
Sakamoto K, Kanematsu Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, et al. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017;11:33-39 pubmed publisher
Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
Lauzon M, Drevelle O, Faucheux N. Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells. Sci Rep. 2017;7:4695 pubmed publisher
Mitrofan C, Appleby S, Nash G, Mallat Z, Chilvers E, Upton P, et al. Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J Biol Chem. 2017;292:13714-13726 pubmed publisher
Abdullahi W, Brzica H, Ibbotson K, Davis T, Ronaldson P. Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor. J Cereb Blood Flow Metab. 2017;37:2340-2345 pubmed publisher
Breitkopf Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, et al. BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut. 2017;66:939-954 pubmed publisher
Tachida Y, Izumi N, Sakurai T, Kobayashi H. Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells. Biol Open. 2017;6:370-380 pubmed publisher
Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K, et al. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. Cancer Sci. 2017;108:151-155 pubmed publisher
Fujioka Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron R. Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential. J Clin Med. 2016;5: pubmed
Yuan H, Sehgal P. MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9). PLoS ONE. 2016;11:e0166382 pubmed publisher
Kraehling J, Chidlow J, Rajagopal C, Sugiyama M, Fowler J, Lee M, et al. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016;7:13516 pubmed publisher
Appleby S, Mitrofan C, Crosby A, Hoenderdos K, Lodge K, Upton P, et al. Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium. J Immunol. 2016;197:3302-3314 pubmed publisher
Yoon B, Chung Y, Yoo S, Kawara K, Kim J, Yoo I, et al. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis. J Biol Chem. 2016;291:4048-57 pubmed publisher
Levet S, Ouarné M, Ciais D, Coutton C, Subileau M, Mallet C, et al. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A. 2015;112:E3207-15 pubmed publisher
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, et al. BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses. PLoS ONE. 2015;10:e0122892 pubmed publisher
Wöltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, et al. Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis. J Biol Chem. 2014;289:25486-96 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, et al. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol. 2013;31:440-7 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Young K, Conley B, Romero D, Tweedie E, O Neill C, Pinz I, et al. BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood. 2012;120:4263-73 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers T, et al. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012;119:6162-71 pubmed publisher
Yao Y, Jumabay M, Ly A, Radparvar M, Wang A, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012;119:5037-47 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Ricard N, Bidart M, Mallet C, Lesca G, Giraud S, Prudent R, et al. Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations. Blood. 2010;116:1604-12 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Lin L, Valore E, Nemeth E, Goodnough J, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-9 pubmed
David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
image
image 1 :
R&D Systems 3209-BP-010/CF image 1
Recombinant Human BMP-9 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
3209-BP/CF
SKU :
3209-BP-010/CF
product name :
Recombinant Human BMP-9 Protein, CF
description :
The Recombinant Human BMP-9 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human BMP-9 Protein, CF has been validated for the following applications: Bioactivity.
target :
BMP-9
unit size :
10 ug
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening.
observed molecular weight :
13 kDa, reducing conditions
theoretical molecular weight :
12.1 kDa (monomer)
gene symbol :
GDF2
details of functionality :
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.4-1.6 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9UK05
applications :
Bioactivity
product keywords :
3209-BP, rhBMP-9, hBMP-9, carrier-free, carrier free, 32O9-BP/CF, 3209BP/CF, cytokinegrowthfact, BMP9, BMP 9, cytokine, cytokines
source :
CHO-derived Recombinant Human BMP-9 Protein, CF
USD :
488
USD 2025 :
493 USD
alt names :
BMP9, BMP9BMP-9Bone morphogenetic protein 9, GDF2, GDF-2, growth differentiation factor 2, growth/differentiation factor 2
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.