Recombinant Human Calcineurin Protein, CF | R&D Systems 3160-CA-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Calcineurin Protein, CF

catalog :

3160-CA-020

quantity :

20 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Masaki T, Habara M, Hanaki S, Sato Y, Tomiyasu H, Miki Y, et al. Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc. Sci Rep. 2023;13:13116 pubmed publisher
Goshima T, Habara M, Maeda K, Hanaki S, Kato Y, Shimada M. Calcineurin regulates cyclin D1 stability through dephosphorylation at T286. Sci Rep. 2019;9:12779 pubmed publisher
Dutta D, Barr V, Akpan I, Mittelstadt P, Singha L, Samelson L, et al. Recruitment of calcineurin to the TCR positively regulates T cell activation. Nat Immunol. 2017;18:196-204 pubmed publisher
Duan L, Cobb M. Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proc Natl Acad Sci U S A. 2010;107:22314-9 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3160-CA

SKU :

3160-CA-020

product name :

Recombinant Human Calcineurin Protein, CF

Description :

The Recombinant Human Calcineurin Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Calcineurin Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Calcineurin

category :

Proteins and Enzymes

unit size :

20 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES, CaCl2, MgCl2, DTT and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

43-65 kDa 15-20 kDa, reducing conditions

theoretical molecular weight :

57 kDa (Calcineurin A), 18 kDa (Calcineurin B)

gene symbol :

PPP3CA

details of functionality :

Measured by its ability to dephosphorylate the peptide substrate, DLDVPIPGRFDRRVS(PO3)VAAE(Catalog # ES012 ). The specific activity is 900 nmol/min/mg, under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_000935 (Calcineurin A) NP_000936 (Calcineurin B

applications :

Enzyme Activity

source :

Sf 21 (baculovirus)-derived Recombinant Human Calcineurin Protein

USD :

423 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage