This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
catalog :
315-BR
quantity :
100 ug
price :
419 USD
citations: 10
Reference
Martínez V, Sacedón R, Hidalgo L, Valencia J, Fernández Sevilla L, Hernández López C, et al. The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS ONE. 2015;10:e0131453 pubmed publisher
Wöltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, et al. Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol. 2015;97:627-34 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Steinbicker A, Sachidanandan C, Vonner A, Yusuf R, Deng D, Lai C, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117:4915-23 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed
product information
brand :
R&D Systems
master code :
315-BR
SKU :
315-BR-100
product name :
Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
description :
The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein has been validated for the following applications: Bioactivity.
target :
BMPR-IA/ALK-3
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
55 kDa, reducing conditions
theoretical molecular weight :
41.5 kDa (monomer)
gene symbol :
BMPR1A
details of functionality :
Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.1-0.3 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
315-BR
accessionNumbers :
CAA80257
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human BMPR-IA/ALK-3 protein Human BMPR-IA (Gln24 - Arg152) Accession # CAA80257 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus
extended description :
A New rh BMPR-IA is Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity!
2020 USD :
419
2021 USD :
419 USD
product details :
A New rh BMPR-IA is Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity!
alt names :
ACVRLK310q23del, ALK-3, ALK3EC 2.7.11.30, BMP type-1A receptor, BMPR1A, BMPR-1A, BMPRIA, bone morphogenetic protein receptor type-1A, bone morphogenetic protein receptor, type IA, CD292, CD292 antigen, EC 2.7.11, Serine/threonine-protein kinase receptor R5, SKR5, type II-like kinase 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.