product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF
catalog :
315-BR-100/CF
quantity :
100 ug
price :
518 USD
more info or order :
R&D Systems product webpage
citations: 12
Reference
Mang T, Kleinschmidt Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A. BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. J Cell Sci. 2020;133: pubmed publisher
Martínez V, Sacedón R, Hidalgo L, Valencia J, Fernández Sevilla L, Hernández López C, et al. The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS ONE. 2015;10:e0131453 pubmed publisher
Wöltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, et al. Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol. 2015;97:627-34 pubmed publisher
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, et al. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood. 2013;122:3767-77 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Steinbicker A, Sachidanandan C, Vonner A, Yusuf R, Deng D, Lai C, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117:4915-23 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
315-BR/CF
SKU :
315-BR-100/CF
product name :
Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF
Description :
The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
BMPR-IA/ALK-3
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
55 kDa, reducing conditions
theoretical molecular weight :
41.5 kDa (monomer)
gene symbol :
BMPR1A
details of functionality :
Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.1-0.3 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
CAA80257
applications :
Bioactivity
source :
NS0-derived Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
extended description :
A New rh BMPR-IA is Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity!
USD :
518 USD
product details :
A New rh BMPR-IA is Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity!
alt names :
ACVRLK310q23del, ALK-3, ALK3EC 2.7.11.30, BMP type-1A receptor, BMPR1A, BMPR-1A, BMPRIA, bone morphogenetic protein receptor type-1A, bone morphogenetic protein receptor, type IA, CD292, CD292 antigen, EC 2.7.11, Serine/threonine-protein kinase receptor R5, SKR5, type II-like kinase 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.