product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-4 Protein
catalog :
314-BP-010
quantity :
10 ug (also 50 ug, 500 ug, 1 mg)
price :
416 USD
more info or order :
citations: 492
Reference
Frum T, Hsu P, Hein R, Conchola A, Zhang C, Utter O, et al. Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung. bioRxiv. 2023;: pubmed publisher
Maeda Y, Isomura A, Masaki T, Kageyama R. Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21. Cell Rep. 2023;42:112520 pubmed publisher
Matkovic Leko I, Schneider R, Thimraj T, Schrode N, Beitler D, Liu H, et al. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nat Protoc. 2023;18:2283-2312 pubmed publisher
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, et al. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell. 2023;30:632-647.e10 pubmed publisher
Teague S, Primavera G, Chen B, Freeburne E, Khan H, Jo K, et al. The time integral of BMP signaling determines fate in a stem cell model for early human development. bioRxiv. 2023;: pubmed publisher
Li S, Wang C, Montel Hagen A, Chen H, Lopez S, Zhou O, et al. Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. Cell Rep. 2023;42:112241 pubmed publisher
Fan Y, Hackland J, Baggiolini A, Hung L, Zhao H, Zumbo P, et al. hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease. Cell Stem Cell. 2023;30:264-282.e9 pubmed publisher
Shono M, Kishimoto K, Hikabe O, Hayashi M, Semi K, Takashima Y, et al. Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling. Sci Rep. 2023;13:3186 pubmed publisher
Dicks A, Maksaev G, Harissa Z, Savadipour A, Tang R, Steward N, et al. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. elife. 2023;12: pubmed publisher
Cohn E, Clayton B, Madhavan M, Yacoub S, Federov Y, Paul Friedman K, et al. Pervasive environmental chemicals impair oligodendrocyte development. bioRxiv. 2023;: pubmed publisher
Liu Q, Liu Z, Gu H, Ge Y, Wu X, Zuo F, et al. Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods. Regen Ther. 2023;22:39-49 pubmed publisher
Wang N, He J, Feng X, Liao S, Zhao Y, Tang F, et al. Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8. elife. 2023;12: pubmed publisher
Feige L, Kozaki T, Dias de Melo G, Guillemot V, Larrous F, Ginhoux F, et al. Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses. Viruses. 2022;15: pubmed publisher
Oba T, Okamoto S, Ueno Y, Matsuo M, Tadokoro T, Kobayashi S, et al. In vitro elastic cartilage reconstruction using human auricular perichondrial chondroprogenitor cell-derived micro 3D spheroids. J Tissue Eng. 2022;13:20417314221143484 pubmed publisher
Yoo S, Lee E, Thang N, La H, Lee H, Park C, et al. INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation. Int J Mol Sci. 2022;23: pubmed publisher
Hayashi M, Zywitza V, Naitou Y, Hamazaki N, Goeritz F, Hermes R, et al. Robust induction of primordial germ cells of white rhinoceros on the brink of extinction. Sci Adv. 2022;8:eabp9683 pubmed publisher
Kaserman J, Werder R, Wang F, Matte T, Higgins M, Dodge M, et al. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022;41:111775 pubmed publisher
Borges J, S xe6 tra R, Volchuk A, Bugge M, Devant P, Sporsheim B, et al. Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. elife. 2022;11: pubmed publisher
Shang D, Lan T, Wang Y, Li X, Liu Q, Dong H, et al. PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders. Cell Biosci. 2022;12:194 pubmed publisher
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, et al. Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods. 2022;2:100317 pubmed publisher
Li Z, Fang F, Long Y, Zhao Q, Wang X, Ye Z, et al. The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate. Cell Biosci. 2022;12:181 pubmed publisher
Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
Li J, Wiesinger A, Fokkert L, Boukens B, Verkerk A, Christoffels V, et al. Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. J Tissue Eng. 2022;13:20417314221127908 pubmed publisher
Yang Y, Kim J, Xie J, Chaugule S, Lin C, Ma H, et al. Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery. Nat Commun. 2022;13:6175 pubmed publisher
Beucher A, Miguel Escalada I, Balboa D, De Vas M, Maestro M, García Hurtado J, et al. The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022;24:1528-1540 pubmed publisher
Liu J, Liu Z, Zhang J, Chen X, Chen J, Sui L, et al. Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner. Pharmaceutics. 2022;14: pubmed publisher
Luce E, Steichen C, Abed S, Weber A, Leboulch P, Maouche Chr xe9 tien L, et al. Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells. Int J Mol Sci. 2022;23: pubmed publisher
Yang D, Gomez Garcia J, Funakoshi S, Tran T, Fernandes I, Bader G, et al. Modeling human multi-lineage heart field development with pluripotent stem cells. Cell Stem Cell. 2022;29:1382-1401.e8 pubmed publisher
Tang Y, Kwiatkowski D, Henske E. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment. Nat Commun. 2022;13:5018 pubmed publisher
Martin S, Allan K, Pinkard O, Sweet T, Tesar P, Coller J. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay. Nat Commun. 2022;13:5003 pubmed publisher
Ai Z, Xiang X, Xiang Y, Szczerbinska I, Qian Y, Xu X, et al. Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency. Cell Rep. 2022;40:111240 pubmed publisher
Kishimoto K, Iwasawa K, Sorel A, Ferran Heredia C, Han L, Morimoto M, et al. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nat Protoc. 2022;17:2699-2719 pubmed publisher
Fan X, Cyganek L, Nitschke K, Uhlig S, Nuhn P, Bieback K, et al. Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Jing R, Scarfò I, Najia M, Lummertz da Rocha E, Han A, Sanborn M, et al. EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity. Cell Stem Cell. 2022;29:1181-1196.e6 pubmed publisher
Shonibare Z, Monavarian M, O CONNELL K, Altomare D, Shelton A, Mehta S, et al. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep. 2022;40:111066 pubmed publisher
Ng K, Lim J, Tan Y, Quek D, Lim Z, Pantelireis N, et al. Sox2 in the dermal papilla regulates hair follicle pigmentation. Cell Rep. 2022;40:111100 pubmed publisher
Cho Y, Yoon Y, Im H, Son Y, Kim M, Saha A, et al. Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Nat Commun. 2022;13:4084 pubmed publisher
xc1 vila Gonz xe1 lez D, Portillo W, Barrag xe1 n xc1 lvarez C, Hernández Montes G, Flores Garza E, Molina Hern xe1 ndez A, et al. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. elife. 2022;11: pubmed publisher
Ohgushi M, Taniyama N, Vandenbon A, Eiraku M. Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model. Cell Rep. 2022;39:110973 pubmed publisher
Tsujisaka Y, Hatani T, Okubo C, Ito R, Kimura A, Narita M, et al. Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting. Stem Cell Reports. 2022;17:1772-1785 pubmed publisher
Hayashi Y, Kawabata K, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, et al. MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. Cell Rep. 2022;39:110805 pubmed publisher
Jeong J, Kim T, Kim M, Jung Y, Kim K, Shim S, et al. Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids. Biology (Basel). 2022;11: pubmed publisher
Rivera Arbel xe1 ez J, Cofi xf1 o Fabres C, Schwach V, Boonen T, Ten Den S, Vermeul K, et al. Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application. PLoS ONE. 2022;17:e0266834 pubmed publisher
Gage B, Merlin S, Olgasi C, Follenzi A, Keller G. Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors. Cell Rep. 2022;39:110621 pubmed publisher
Krumm J, Sekine K, Samaras P, Brazovskaja A, Breunig M, Yasui R, et al. High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development. Cell Rep. 2022;38:110604 pubmed publisher
Wang Z, McWilliams Koeppen H, Reza H, Ostberg J, Chen W, Wang X, et al. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022;29:515-527.e8 pubmed publisher
Zywitza V, Rusha E, Shaposhnikov D, Ruiz Orera J, Telugu N, Rishko V, et al. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Sci Rep. 2022;12:3100 pubmed publisher
Uehara K, Koyanagi Aoi M, Koide T, Itoh T, Aoi T. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. Stem Cell Reports. 2022;17:820-834 pubmed publisher
Hu X, Lin C, Ruan N, Huang Z, Zhang Y, Hu X. Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis. Front Physiol. 2022;13:823275 pubmed publisher
Ribeiro M, Rivera Arbel xe1 ez J, Cofi xf1 o Fabres C, Schwach V, Slaats R, Ten Den S, et al. A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues. J Pers Med. 2022;12: pubmed publisher
Li X, Morgan C, Goff L, Doetzlhofer A. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv. 2022;8:eabj7651 pubmed publisher
Budjan C, Liu S, Ranga A, Gayen S, Pourqui xe9 O, Hormoz S. Paraxial mesoderm organoids model development of human somites. elife. 2022;11: pubmed publisher
Finkbeiner C, Ortu xf1 o Lizar xe1 n I, Sridhar A, Hooper M, Petter S, Reh T. Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition. Cell Rep. 2022;38:110294 pubmed publisher
Xiang X, Tao Y, DiRusso J, Hsu F, Zhang J, Xue Z, et al. Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections. Nat Commun. 2022;13:463 pubmed publisher
Eicher A, Kechele D, Sundaram N, Berns H, Poling H, Haines L, et al. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022;29:36-51.e6 pubmed publisher
Kathiriya J, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux C, et al. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 2021;: pubmed publisher
Yucer N, Ahdoot R, Workman M, Laperle A, Recouvreux M, Kurowski K, et al. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. Cell Rep. 2021;37:110146 pubmed publisher
Xu F, Deng C, Ren Z, Sun L, Meng Y, Liu W, et al. Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells. Cell Rep. 2021;37:110063 pubmed publisher
de Souza A, Bressan F, Pieri N, Botigelli R, Revay T, Haddad S, et al. Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients. Cells. 2021;10: pubmed publisher
Geusz R, Wang A, Lam D, Vinckier N, Alysandratos K, Roberts D, et al. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 2021;12:6636 pubmed publisher
Valcourt J, Huang R, Kundu S, Venkatasubramanian D, Kingston R, Ramanathan S. Modulating mesendoderm competence during human germ layer differentiation. Cell Rep. 2021;37:109990 pubmed publisher
Duan X, Tang X, Nair M, Zhang T, Qiu Y, Zhang W, et al. An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Rep. 2021;37:109920 pubmed publisher
Vojtek M, Chambers I. Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry. Life Sci Alliance. 2021;4: pubmed publisher
Zheng M, Erhardt S, Ai D, Wang J. Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development. Int J Mol Sci. 2021;22: pubmed publisher
Fan Y, Min Z, Alsolami S, Ma Z, Zhang E, Chen W, et al. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 2021;7:81 pubmed publisher
Martin Inaraja M, Ferreira M, Taelman J, Eguizabal C, Chuva de Sousa Lopes S. Improving In Vitro Culture of Human Male Fetal Germ Cells. Cells. 2021;10: pubmed publisher
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, et al. RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia. Cell Rep. 2021;36:109559 pubmed publisher
Sattler K, El Battrawy I, Cyganek L, Lang S, Lan H, Li X, et al. TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes. Sci Rep. 2021;11:14689 pubmed publisher
Degani N, Lubelsky Y, Perry R, Ainbinder E, Ulitsky I. Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage. PLoS Genet. 2021;17:e1009681 pubmed publisher
Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, et al. Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells. Sci Rep. 2021;11:14167 pubmed publisher
Zhang X, Mandric I, Nguyen K, Nguyen T, Pellegrini M, Grove J, et al. Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development. Front Cell Dev Biol. 2021;9:653305 pubmed publisher
Wosczyna M, Perez Carbajal E, Wagner M, Paredes S, Konishi C, Liu L, et al. Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. Cell Stem Cell. 2021;28:1323-1334.e8 pubmed publisher
Mithal A, Hume A, Lindstrom Vautrin J, Villacorta Martin C, Olejnik J, Bullitt E, et al. Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response. Stem Cell Reports. 2021;16:940-953 pubmed publisher
Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. 2021;28:1023-1039.e13 pubmed publisher
Campostrini G, Meraviglia V, Giacomelli E, van Helden R, Yiangou L, Davis R, et al. Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells. Nat Protoc. 2021;16:2213-2256 pubmed publisher
Sahni G, Chang S, Meng J, Tan J, Fatien J, Bonnard C, et al. A Micropatterned Human-Specific Neuroepithelial Tissue for Modeling Gene and Drug-Induced Neurodevelopmental Defects. Adv Sci (Weinh). 2021;8:2001100 pubmed publisher
Rodrigues Toste de Carvalho A, Liu H, Chen Y, Porotto M, Moscona A, Snoeck H. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Nat Protoc. 2021;16:1802-1829 pubmed publisher
Yuan W, Yao Z, Veerapandian V, Yang X, Wang X, Chen D, et al. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Int J Biol Sci. 2021;17:527-538 pubmed publisher
Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, et al. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Res. 2021;31:526-541 pubmed publisher
Wang T, Pine A, Kotini A, Yuan H, Zamparo L, Starczynowski D, et al. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell Stem Cell. 2021;28:1074-1089.e7 pubmed publisher
Lu T, Houghton S, Magdeldin T, Dur xe1 n J, Minotti A, Snead A, et al. Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Shah P, Lv W, Rhoades J, Poleshko A, Abbey D, Caporizzo M, et al. Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell. 2021;: pubmed publisher
Prajapati C, Ojala M, Lappi H, Aalto Setala K, Pekkanen Mattila M. Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods. Stem Cell Res. 2021;51:102176 pubmed publisher
Wu C, Dicks A, Steward N, Tang R, Katz D, Choi Y, et al. Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis. Nat Commun. 2021;12:362 pubmed publisher
Souidi M, Sleiman Y, Acimovic I, Pribyl J, Charrabi A, Baecker V, et al. Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids. Int J Mol Sci. 2021;22: pubmed publisher
Ji Z, Li Y, Liu S, Sharrocks A. The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. Nucleic Acids Res. 2021;49:1345-1363 pubmed publisher
Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, et al. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat Commun. 2021;12:109 pubmed publisher
Zheng Y, Shao Y, Fu J. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021;16:309-326 pubmed publisher
Adusumilli V, Walker T, Overall R, Klatt G, Zeidan S, Zocher S, et al. ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence. Cell Stem Cell. 2021;28:300-314.e6 pubmed publisher
Hawkins F, Suzuki S, Beermann M, Barillà C, Wang R, Villacorta Martin C, et al. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021;28:79-95.e8 pubmed publisher
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed publisher
Monkley S, Krishnaswamy J, Göransson M, Clausen M, Meuller J, Thorn K, et al. Optimised generation of iPSC-derived macrophages and dendritic cells that are functionally and transcriptionally similar to their primary counterparts. PLoS ONE. 2020;15:e0243807 pubmed publisher
Uchimura K, Wu H, Yoshimura Y, Humphreys B. Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling. Cell Rep. 2020;33:108514 pubmed publisher
Rocha A, de Lima T, de Souza G, Corr xea a R, Ferrucci D, Rodrigues B, et al. Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv. 2020;6: pubmed publisher
Qiu J, Nordling S, Vasavada H, Butcher E, Hirschi K. Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Cell Rep. 2020;33:108465 pubmed publisher
Chitiashvili T, Dror I, Kim R, Hsu F, Chaudhari R, Pandolfi E, et al. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation. Nat Cell Biol. 2020;22:1436-1446 pubmed publisher
Hwang Y, Suzuki S, Seita Y, Ito J, Sakata Y, Aso H, et al. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Nat Commun. 2020;11:5656 pubmed publisher
Nora E, Caccianini L, Fudenberg G, So K, Kameswaran V, Nagle A, et al. Molecular basis of CTCF binding polarity in genome folding. Nat Commun. 2020;11:5612 pubmed publisher
Lee H, Seidl C, Sun R, Glinka A, Niehrs C. R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun. 2020;11:5570 pubmed publisher
Gazit V, Swietlicki E, Liang M, Surti A, McDaniel R, Geisman M, et al. Stem cell and niche regulation in human short bowel syndrome. JCI Insight. 2020;5: pubmed publisher
Fukushima H, Yoshioka M, Kawatou M, López Dávila V, Takeda M, Kanda Y, et al. Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells. PLoS ONE. 2020;15:e0241287 pubmed publisher
Pellegrini L, Albecka A, Mallery D, Kellner M, Paul D, Carter A, et al. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell. 2020;27:951-961.e5 pubmed publisher
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, et al. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020;22:1295-1306 pubmed publisher
Hwang H, Liu R, Maxwell J, Yang J, Xu C. Machine learning identifies abnormal Ca2+ transients in human induced pluripotent stem cell-derived cardiomyocytes. Sci Rep. 2020;10:16977 pubmed publisher
Park C, Nguyen L, Yong D. Development of Colonic Organoids Containing Enteric Nerves or Blood Vessels from Human Embryonic Stem Cells. Cells. 2020;9: pubmed publisher
Huang J, Hume A, Abo K, Werder R, Villacorta Martin C, Alysandratos K, et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020;27:962-973.e7 pubmed publisher
Crosse E, Gordon Keylock S, Rybtsov S, Binagui Casas A, Felchle H, Nnadi N, et al. Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development. Cell Stem Cell. 2020;27:822-839.e8 pubmed publisher
Dost A, Moye A, Vedaie M, Tran L, Fung E, Heinze D, et al. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell Stem Cell. 2020;27:663-678.e8 pubmed publisher
Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nat Commun. 2020;11:4158 pubmed publisher
Duan F, Guo L, Yang L, Han Y, Thakur A, Nilsson Payant B, et al. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Res Sq. 2020;: pubmed publisher
Zhang L, Avery J, Yin A, Singh A, Cliff T, Yin H, et al. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State. Cell Stem Cell. 2020;27:784-797.e11 pubmed publisher
Grosswendt S, Kretzmer H, Smith Z, Kumar A, Hetzel S, Wittler L, et al. Epigenetic regulator function through mouse gastrulation. Nature. 2020;584:102-108 pubmed publisher
Ibrahim A, Hussein K, Wang F, Wan M, Saad N, Essa M, et al. Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration. J Clin Med. 2020;9: pubmed publisher
Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, et al. Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. Cell Rep. 2020;32:107870 pubmed publisher
Huang J, Hume A, Abo K, Werder R, Villacorta Martin C, Alysandratos K, et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020;: pubmed publisher
Zhu H, Blum R, Bernareggi D, Ask E, Wu Z, Hoel H, et al. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020;27:224-237.e6 pubmed publisher
Wesely J, Kotini A, Izzo F, Luo H, Yuan H, Sun J, et al. Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells. Cell Rep. 2020;31:107688 pubmed publisher
Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, et al. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. Cell Rep. 2020;31:107715 pubmed publisher
Takeishi K, Collin de l Hortet A, Wang Y, Handa K, Guzman Lepe J, Matsubara K, et al. Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells. Cell Rep. 2020;31:107711 pubmed publisher
Nafria M, Keane P, Ng E, Stanley E, Elefanty A, Bonifer C. Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells. Cell Rep. 2020;31:107691 pubmed publisher
Giacomelli E, Meraviglia V, Campostrini G, Cochrane A, Cao X, van Helden R, et al. Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease. Cell Stem Cell. 2020;26:862-879.e11 pubmed publisher
Liang H, Zhang P, Bai H, Huang J, Yang H. TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes. Stem Cell Res Ther. 2020;11:196 pubmed publisher
Martín Fernandez M, Bravo García Morato M, Gruber C, Murias Loza S, Malik M, Alsohime F, et al. Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions. Cell Rep. 2020;31:107633 pubmed publisher
Grosch M, Ittermann S, Rusha E, Greisle T, Ori C, Truong D, et al. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 2020;18:42 pubmed publisher
Krouwels A, Iljas J, Kragten A, Dhert W, Oner F, Tryfonidou M, et al. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. Int J Mol Sci. 2020;21: pubmed publisher
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, et al. PPARγ and PPARα synergize to induce robust browning of white fat in vivo. Mol Metab. 2020;36:100964 pubmed publisher
Yamashiro C, Sasaki K, Yokobayashi S, Kojima Y, Saitou M. Generation of human oogonia from induced pluripotent stem cells in culture. Nat Protoc. 2020;15:1560-1583 pubmed publisher
Pan T, Martinez M, Hubka K, Song J, Lin S, Yu G, et al. Cabozantinib Reverses Renal Cell Carcinoma-mediated Osteoblast Inhibition in Three-dimensional Coculture In Vitro and Reduces Bone Osteolysis In Vivo. Mol Cancer Ther. 2020;19:1266-1278 pubmed publisher
Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher
Riedl M, Witzmann C, Koch M, Lang S, Kerschbaum M, Baumann F, et al. Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist. Int J Mol Sci. 2020;21: pubmed publisher
Kim J, Hwang S, Ryu J, Hong H, Lee J, Lee S, et al. ER stress reliever enhances functionalities of in vitro cultured hepatocytes. Stem Cell Res. 2020;43:101732 pubmed publisher
Mong E, Yang Y, Akat K, Canfield J, VanWye J, Lockhart J, et al. Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition. Sci Rep. 2020;10:3029 pubmed publisher
Saotome H, Ito A, Kubo A, Inui M. Generation of a Quantitative Luciferase Reporter for Sox9 SUMOylation. Int J Mol Sci. 2020;21: pubmed publisher
Wang Y, Lifshitz L, Gellatly K, Vinton C, Busman Sahay K, McCauley S, et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21:274-286 pubmed publisher
Okubo T, Hayashi R, Shibata S, Kudo Y, Ishikawa Y, Inoue S, et al. Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells. J Biol Chem. 2020;295:3456-3465 pubmed publisher
Sridhar A, Hoshino A, Finkbeiner C, Chitsazan A, Dai L, Haugan A, et al. Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures. Cell Rep. 2020;30:1644-1659.e4 pubmed publisher
Hu J, Liang H, Zhang H, Yang M, Sun W, Zhang P, et al. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020;48:2733-2748 pubmed publisher
Horvath A, Christ T, Koivumäki J, Prondzynski M, Zech A, Spohn M, et al. Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca). Cells. 2020;9: pubmed publisher
Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
Matsuura K, Wada M, Sakaguchi K, Matsuhashi Y, Shimizu T. Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates. Regen Ther. 2019;12:6-13 pubmed publisher
Chen D, Sun N, Hou L, Kim R, Faith J, Aslanyan M, et al. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019;29:4568-4582.e5 pubmed publisher
Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, et al. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2019;: pubmed publisher
Roudnicky F, Lan Y, Friesen M, Dernick G, Zhang J, Staempfli A, et al. Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype. Int J Mol Sci. 2019;20: pubmed publisher
Kuwahara A, Yamasaki S, Mandai M, Watari K, Matsushita K, Fujiwara M, et al. Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue. Sci Rep. 2019;9:18936 pubmed publisher
Nagel S, Scherr M, MacLeod R, Pommerenke C, Koeppel M, Meyer C, et al. NKL homeobox gene activities in normal and malignant myeloid cells. PLoS ONE. 2019;14:e0226212 pubmed publisher
Sahabian A, Sgodda M, Naujok O, Dettmer R, Dahlmann J, Manstein F, et al. Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential. Cells. 2019;8: pubmed publisher
Ali M, Kabir F, Thomson J, Ma Y, Qiu C, Delannoy M, et al. Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies. Sci Rep. 2019;9:18552 pubmed publisher
JACOB A, Vedaie M, Roberts D, Thomas D, Villacorta Martin C, Alysandratos K, et al. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nat Protoc. 2019;14:3303-3332 pubmed publisher
Li Z, Fang F, Zhao Q, Li H, Xiong C. Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells. Stem Cell Res Ther. 2019;10:324 pubmed publisher
Seo D, Jung S, Park J, Lee J, Ha J, Kim M, et al. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway. EBioMedicine. 2019;49:55-71 pubmed publisher
Tiemeier G, Wang G, Dumas S, Sol W, Avramut M, Karakach T, et al. Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation. Stem Cell Reports. 2019;13:803-816 pubmed publisher
Grajcarek J, Monlong J, Nishinaka Arai Y, Nakamura M, Nagai M, Matsuo S, et al. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations. Nat Commun. 2019;10:4856 pubmed publisher
Stubb A, Guzman C, Närvä E, Aaron J, Chew T, Saari M, et al. Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 2019;10:4756 pubmed publisher
Sachdeva R, Wu M, Johnson K, Kim H, Celebre A, Shahzad U, et al. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma. Sci Rep. 2019;9:14569 pubmed publisher
Song W, Chiu A, Wang L, Schwartz R, Li B, Bouklas N, et al. Engineering transferrable microvascular meshes for subcutaneous islet transplantation. Nat Commun. 2019;10:4602 pubmed publisher
Mei Q, Bansal A, Jayakumar M, Zhang Z, Zhang J, Huang H, et al. Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation. Nat Commun. 2019;10:4416 pubmed publisher
Zheng Y, Xue X, Shao Y, Wang S, Esfahani S, Li Z, et al. Controlled modelling of human epiblast and amnion development using stem cells. Nature. 2019;573:421-425 pubmed publisher
Yoshimatsu S, Sone T, Nakajima M, Sato T, Okochi R, Ishikawa M, et al. A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology. PLoS ONE. 2019;14:e0221164 pubmed publisher
Song C, Xu F, Ren Z, Zhang Y, Meng Y, Yang Y, et al. Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells. Stem Cell Reports. 2019;13:338-351 pubmed publisher
Segal J, Kent D, Wesche D, Ng S, Serra M, Oulès B, et al. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019;10:3350 pubmed publisher
Bai H, Zhang P, Ma L, Liang H, Wei G, Yang H. SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes. Stem Cells. 2019;: pubmed publisher
Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, et al. Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model. Sci Rep. 2019;9:9831 pubmed publisher
Ohta R, Sugimura R, Niwa A, Saito M. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp. 2019;: pubmed publisher
Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, et al. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica. 2019;: pubmed publisher
Prajapati DiNubila M, Benito Gonzalez A, Golden E, Zhang S, Doetzlhofer A. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. elife. 2019;8: pubmed publisher
Blázquez Medela A, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, et al. Noggin depletion in adipocytes promotes obesity in mice. Mol Metab. 2019;25:50-63 pubmed publisher
Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher
Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Rep. 2019;27:599-615.e12 pubmed publisher
Sattler K, El Battrawy I, Zhao Z, Schrottenberg C, Yücel G, Lan H, et al. Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes. Sci Rep. 2019;9:5651 pubmed publisher
Harms M, Li Q, Lee S, Zhang C, Kull B, Hallen S, et al. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes. Cell Rep. 2019;27:213-225.e5 pubmed publisher
Barber K, Studer L, Fattahi F. Derivation of enteric neuron lineages from human pluripotent stem cells. Nat Protoc. 2019;14:1261-1279 pubmed publisher
Okada H, Nakanishi C, Yoshida S, Shimojima M, Yokawa J, Mori M, et al. Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia. Sci Rep. 2019;9:4695 pubmed publisher
Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, et al. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility. Cell Stem Cell. 2019;: pubmed publisher
Hoshino A, Horvath S, Sridhar A, Chitsazan A, Reh T. Synchrony and asynchrony between an epigenetic clock and developmental timing. Sci Rep. 2019;9:3770 pubmed publisher
Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci Rep. 2019;9:3713 pubmed publisher
Senft A, Bikoff E, Robertson E, Costello I. Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. Nat Commun. 2019;10:1089 pubmed publisher
Colunga T, Hayworth M, Kreß S, Reynolds D, Chen L, Nazor K, et al. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 2019;26:2566-2579.e10 pubmed publisher
Ho W, Freem L, Zhao D, Painter K, Woolley T, Gaffney E, et al. Feather arrays are patterned by interacting signalling and cell density waves. PLoS Biol. 2019;17:e3000132 pubmed publisher
Inoue M, Kajiwara K, Yamaguchi A, Kiyono T, Samura O, Akutsu H, et al. Autonomous trisomic rescue of Down syndrome cells. Lab Invest. 2019;99:885-897 pubmed publisher
Ito E, Miyagawa S, Takeda M, Kawamura A, Harada A, Iseoka H, et al. Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application. Sci Rep. 2019;9:1881 pubmed publisher
Fujisawa S, Komatsubara M, Ogura Ochi K, Tsukamoto Yamauchi N, Toma K, Inagaki K, et al. Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells. Peptides. 2019;113:35-40 pubmed publisher
Yan Y, Bejoy J, Xia J, Griffin K, Guan J, Li Y. Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells. Sci Rep. 2019;9:1295 pubmed publisher
Li L, Wang Y, Torkelson J, Shankar G, Pattison J, Zhen H, et al. TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Cell Stem Cell. 2019;24:271-284.e8 pubmed publisher
Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, et al. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019;24:447-461.e8 pubmed publisher
Montel Hagen A, Seet C, Li S, Chick B, Zhu Y, Chang P, et al. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019;24:376-389.e8 pubmed publisher
Bradford S, Ranghini E, Grimley E, Lee P, Dressler G. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. J Biol Chem. 2019;294:3125-3136 pubmed publisher
Chen D, Liu W, Zimmerman J, Pastor W, Kim R, Hosohama L, et al. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Cell Rep. 2018;25:3591-3602.e5 pubmed publisher
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo J, et al. yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell. 2019;24:318-327.e8 pubmed publisher
Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, et al. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Rep. 2018;25:2563-2576.e9 pubmed publisher
Broda T, McCracken K, Wells J. Generation of human antral and fundic gastric organoids from pluripotent stem cells. Nat Protoc. 2019;14:28-50 pubmed publisher
Weng C, Ding P, Liu Y, Hawse J, Subramaniam M, Wu C, et al. Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. Oncogene. 2019;38:2005-2019 pubmed publisher
Ray P, Chin A, Worley K, Fan J, Kaur G, Wu M, et al. Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping. Proc Natl Acad Sci U S A. 2018;115:E11568-E11577 pubmed publisher
Pattison J, Melo S, Piekos S, Torkelson J, Bashkirova E, Mumbach M, et al. Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nat Genet. 2018;50:1658-1665 pubmed publisher
Smith J, Owen T, Bhagwan J, Mosqueira D, Scott E, Mannhardt I, et al. Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits. Stem Cell Reports. 2018;11:1226-1243 pubmed publisher
Adkar S, Wu C, Willard V, Dicks A, Ettyreddy A, Steward N, et al. Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing. Stem Cells. 2019;37:65-76 pubmed publisher
Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari Jovin S, Dolan D, et al. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun. 2018;9:4234 pubmed publisher
Yoney A, Etoc F, Ruzo A, Carroll T, Metzger J, Martyn I, et al. WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids. elife. 2018;7: pubmed publisher
Zhang Y, Yang Y, Jiang M, Huang S, Zhang W, Al Alam D, et al. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018;23:516-529.e5 pubmed publisher
Delsing L, Dönnes P, Sanchez J, Clausen M, Voulgaris D, Falk A, et al. Barrier Properties and Transcriptome Expression in Human iPSC-Derived Models of the Blood-Brain Barrier. Stem Cells. 2018;36:1816-1827 pubmed publisher
Kirino K, Nakahata T, Taguchi T, Saito M. Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition. Sci Rep. 2018;8:12865 pubmed publisher
Senft A, Costello I, King H, Mould A, Bikoff E, Robertson E. Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming. Cell Rep. 2018;24:1977-1985.e7 pubmed publisher
Di Baldassarre A, D Amico M, Izzicupo P, Gaggi G, Guarnieri S, Mariggio M, et al. Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids. Sci Rep. 2018;8:12028 pubmed publisher
Xu Z, He X, Shi X, Xia Y, Liu X, Wu H, et al. Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes. Stem Cell Res Ther. 2018;9:211 pubmed publisher
Devito L, Donne M, Kolundžić N, Khurana P, Hobbs C, Kaddour G, et al. Induced pluripotent stem cell line from an atopic dermatitis patient heterozygous for c.2282del4 mutation in filaggrin: KCLi001-A. Stem Cell Res. 2018;31:122-126 pubmed publisher
Magro Lopez E, Palmer C, Manso J, Liste I, Zambrano A. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Stem Cell Res Ther. 2018;9:186 pubmed publisher
Koefoed K, Skat Rørdam J, Andersen P, Warzecha C, Pye M, Andersen T, et al. The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development. Sci Rep. 2018;8:9542 pubmed publisher
Li J, Xing F, Chen F, He L, So K, Liu Y, et al. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages. Cell Transplant. 2019;28:510-521 pubmed publisher
Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, et al. An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med. 2018;24:814-822 pubmed publisher
Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, et al. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018;22:893-908.e6 pubmed publisher
Chen Y, Tsai C, Wei Y, Wu Y, Hsu W, Lin H, et al. ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA. Cell Death Dis. 2018;9:437 pubmed publisher
Okamoto R, Takayama K, Akita N, Nagamoto Y, Hosokawa D, Iizuka S, et al. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B. Cell Transplant. 2018;27:299-309 pubmed publisher
Pursani V, Bhartiya D, Tanavde V, Bashir M, Sampath P. Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage. Stem Cell Res Ther. 2018;9:97 pubmed publisher
Jin Y, Liu Y, Li Z, Santostefano K, Shi J, Zhang X, et al. Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery. PLoS ONE. 2018;13:e0194895 pubmed publisher
Esser J, Steiner R, Deckler M, Schmitt H, Engert B, Link S, et al. Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. FEBS J. 2018;285:1419-1436 pubmed publisher
Ostrin E, Little D, Gerner Mauro K, Sumner E, Ríos Corzo R, Ambrosio E, et al. β-Catenin maintains lung epithelial progenitors after lung specification. Development. 2018;145: pubmed publisher
Wang F, Zachar V, Pennisi C, Fink T, Maeda Y, Emmersen J. Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype. Int J Mol Sci. 2018;19: pubmed publisher
Yamashita T, Takayama K, Sakurai F, Mizuguchi H. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Biochem Biophys Res Commun. 2018;496:1269-1275 pubmed publisher
Long C, Li H, Tiburcy M, Rodriguez Caycedo C, Kyrychenko V, Zhou H, et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018;4:eaap9004 pubmed publisher
Kondrashov A, Duc Hoang M, Smith J, Bhagwan J, Duncan G, Mosqueira D, et al. Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells. Stem Cells Dev. 2018;27:391-404 pubmed publisher
Yachie Kinoshita A, Onishi K, Ostblom J, Langley M, Pósfai E, Rossant J, et al. Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions. Mol Syst Biol. 2018;14:e7952 pubmed publisher
Tengroth L, Arebro J, Larsson O, Bachert C, Georén S, Cardell L. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep. 2018;8:1561 pubmed publisher
Sierra R, Hoverter N, Ramirez R, Vuong L, Mortazavi A, Merrill B, et al. TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development. 2018;145: pubmed publisher
Gell J, Zhao J, Chen D, Hunt T, Clark A. PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. Stem Cell Res. 2018;27:46-56 pubmed publisher
Matson J, Dumitru R, Coryell P, Baxley R, Chen W, Twaroski K, et al. Rapid DNA replication origin licensing protects stem cell pluripotency. elife. 2017;6: pubmed publisher
Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher
Li J, Minami I, Shiozaki M, Yu L, Yajima S, Miyagawa S, et al. Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium. Stem Cell Reports. 2017;9:1546-1559 pubmed publisher
Krendl C, Shaposhnikov D, Rishko V, Ori C, Ziegenhain C, Sass S, et al. GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency. Proc Natl Acad Sci U S A. 2017;114:E9579-E9588 pubmed publisher
Ocaña O, Coskun H, Minguillón C, Murawala P, Tanaka E, Galcerán J, et al. A right-handed signalling pathway drives heart looping in vertebrates. Nature. 2017;549:86-90 pubmed publisher
Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, et al. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Sci Rep. 2017;7:10741 pubmed publisher
Kooreman N, de Almeida P, Stack J, Nelakanti R, Diecke S, Shao N, et al. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017;20:1978-1990 pubmed publisher
Xing J, Cao Y, Yu Y, Li H, Song Z, Yu H. In Vitro Micropatterned Human Pluripotent Stem Cell Test (µP-hPST) for Morphometric-Based Teratogen Screening. Sci Rep. 2017;7:8491 pubmed publisher
Palpant N, Wang Y, Hadland B, Zaunbrecher R, Redd M, Jones D, et al. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis. Cell Rep. 2017;20:1597-1608 pubmed publisher
McLennan R, Bailey C, Schumacher L, Teddy J, Morrison J, Kasemeier Kulesa J, et al. DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion. J Cell Biol. 2017;216:3339-3354 pubmed publisher
Shao Y, Taniguchi K, Townshend R, Miki T, Gumucio D, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017;8:208 pubmed publisher
Tsang K, Hyun J, Cheng K, Vargas M, Mehta D, Ushio Fukai M, et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?. Stem Cell Reports. 2017;9:796-806 pubmed publisher
Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Scerbo P, Marchal L, Kodjabachian L. Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. elife. 2017;6: pubmed publisher
Freire A, Waghray A, Soares da Silva F, Resende T, Lee D, Pereira C, et al. Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports. 2017;9:136-148 pubmed publisher
Aberdam E, Petit I, Sangari L, Aberdam D. Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing. PLoS ONE. 2017;12:e0179913 pubmed publisher
Campbell A, Hogestyn J, Folts C, Lopez B, Proschel C, Mock D, et al. Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration. Sci Rep. 2017;7:3978 pubmed publisher
Ogura Ochi K, Fujisawa S, Iwata N, Komatsubara M, Nishiyama Y, Tsukamoto Yamauchi N, et al. Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells. Peptides. 2017;94:19-24 pubmed publisher
Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, et al. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun. 2017;8:15680 pubmed publisher
Yücel G, Zhao Z, El Battrawy I, Lan H, Lang S, Li X, et al. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017;7:2935 pubmed publisher
Kajiwara K, Tanemoto T, Wada S, Karibe J, Ihara N, Ikemoto Y, et al. Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017;8:1701-1713 pubmed publisher
Jeziorowska D, Fontaine V, Jouve C, Villard E, Dussaud S, Akbar D, et al. Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols. Int J Mol Sci. 2017;18: pubmed publisher
Rahman N, Brauer P, Ho L, Usenko T, Tewary M, Zuniga Pflucker J, et al. Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence. Nat Commun. 2017;8:15380 pubmed publisher
Park J, Yan L, Stoddard C, Wang X, Yue Z, Crandall L, et al. Recapitulating and Correcting Marfan Syndrome in a Cellular Model. Int J Biol Sci. 2017;13:588-603 pubmed publisher
Kumar R, Gont A, Perkins T, Hanson J, Lorimer I. Induction of senescence in primary glioblastoma cells by serum and TGFβ. Sci Rep. 2017;7:2156 pubmed publisher
Breckwoldt K, Letuffe Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, et al. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017;12:1177-1197 pubmed publisher
Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher
Uemura M, Ihara M, Maki T, Nakagomi T, Kaji S, Uemura K, et al. Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. Brain Pathol. 2018;28:521-535 pubmed publisher
Hawkins F, Kramer P, JACOB A, Driver I, Thomas D, McCauley K, et al. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017;127:2277-2294 pubmed publisher
Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, et al. Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling. Mol Ther. 2017;25:1420-1433 pubmed publisher
Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, et al. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 2017;36:4963-4974 pubmed publisher
Low K, Wong L, Maldonado M, Manjunath C, Horner C, Perez M, et al. Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System. Stem Cell Reports. 2017;8:1329-1339 pubmed publisher
Warrier S, Van der Jeught M, Duggal G, Tilleman L, Sutherland E, Taelman J, et al. Direct comparison of distinct naive pluripotent states in human embryonic stem cells. Nat Commun. 2017;8:15055 pubmed publisher
Ellis B, Acun A, Can U, Zorlutuna P. Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine. Biomicrofluidics. 2017;11:024105 pubmed publisher
Lee J, Laronde S, Collins T, Shapovalova Z, Tanasijevic B, McNicol J, et al. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency. Cell Rep. 2017;19:20-35 pubmed publisher
Ahrens L, Vonwil D, Christensen J, Shastri V. Gelatin device for the delivery of growth factors involved in endochondral ossification. PLoS ONE. 2017;12:e0175095 pubmed publisher
Sakurai F, Mitani S, Yamamoto T, Takayama K, Tachibana M, Watashi K, et al. Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection. Sci Rep. 2017;7:45698 pubmed publisher
McCauley K, Hawkins F, Serra M, Thomas D, JACOB A, Kotton D. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017;20:844-857.e6 pubmed publisher
Wagner I, Wang H, Weissert P, Straube W, Shevchenko A, Gentzel M, et al. Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration. Dev Cell. 2017;40:608-617.e6 pubmed publisher
Sampaziotis F, de Brito M, Geti I, Bertero A, Hannan N, Vallier L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 2017;12:814-827 pubmed publisher
Tachida Y, Izumi N, Sakurai T, Kobayashi H. Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells. Biol Open. 2017;6:370-380 pubmed publisher
Kojima J, Fukuda A, Taira H, Kawasaki T, Ito H, Kuji N, et al. Efficient production of trophoblast lineage cells from human induced pluripotent stem cells. Lab Invest. 2017;97:1188-1200 pubmed publisher
Giacomelli E, Bellin M, Sala L, van Meer B, Tertoolen L, Orlova V, et al. Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development. 2017;144:1008-1017 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Harding A, Cortez Toledo E, Magner N, Beegle J, Coleal Bergum D, Hao D, et al. Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017;35:909-919 pubmed publisher
Koike H, Zhang R, Ueno Y, Sekine K, Zheng Y, Takebe T, et al. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development. 2017;144:1018-1024 pubmed publisher
Kotini A, Chang C, Chow A, Yuan H, Ho T, Wang T, et al. Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia. Cell Stem Cell. 2017;20:315-328.e7 pubmed publisher
Boswell B, Korol A, West Mays J, Musil L. Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017;28:907-921 pubmed publisher
Chattopadhyay T, Singh R, Gupta S, Surolia A. Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors. 2017;43:195-209 pubmed publisher
Voges H, Mills R, Elliott D, Parton R, Porrello E, Hudson J. Development of a human cardiac organoid injury model reveals innate regenerative potential. Development. 2017;144:1118-1127 pubmed publisher
Tiburcy M, Hudson J, Balfanz P, Schlick S, Meyer T, Chang Liao M, et al. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017;135:1832-1847 pubmed publisher
Mody A, Wordinger R, Clark A. Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-?2 in Human TM Cells. Invest Ophthalmol Vis Sci. 2017;58:849-859 pubmed publisher
Choudhury Y, Toh Y, Xing J, Qu Y, Poh J, Li H, et al. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Sci Rep. 2017;7:41238 pubmed publisher
Ampuja M, Rantapero T, Rodriguez Martinez A, Palmroth M, Alarmo E, Nykter M, et al. Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer. BMC Genomics. 2017;18:68 pubmed publisher
Kadota S, Pabon L, Reinecke H, Murry C. In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts. Stem Cell Reports. 2017;8:278-289 pubmed publisher
McCracken K, Aihara E, Martin B, Crawford C, Broda T, Treguier J, et al. Wnt/β-catenin promotes gastric fundus specification in mice and humans. Nature. 2017;541:182-187 pubmed publisher
Abbo O, Taurand M, Monsarrat P, Raymond I, Arnaud E, De Barros S, et al. Comparison between pediatric and adult adipose mesenchymal stromal cells. Cytotherapy. 2017;19:395-407 pubmed publisher
Tatsinkam A, Rune N, Smith J, Norman J, Mulloy B, Rider C. The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism. Int J Biochem Cell Biol. 2017;83:39-46 pubmed publisher
Yu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed publisher
Suzuki K, Kimura T, Shinoda H, Bai G, Daniels M, Arai Y, et al. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun. 2016;7:13718 pubmed publisher
Protze S, Liu J, Nussinovitch U, Ohana L, Backx P, Gepstein L, et al. Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nat Biotechnol. 2017;35:56-68 pubmed publisher
Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, et al. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016;7:13602 pubmed publisher
de Souza G, Costa J, da Cunha E, Passos J, Ribeiro R, Saraiva M, et al. Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro. Reprod Domest Anim. 2017;52:243-250 pubmed publisher
de Almeida I, Oliveira N, Randall R, Hill C, McCoy J, Stern C. Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction. Dev Biol. 2017;421:161-170 pubmed publisher
Palpant N, Pabon L, Friedman C, Roberts M, Hadland B, Zaunbrecher R, et al. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nat Protoc. 2017;12:15-31 pubmed publisher
Yuan H, Sehgal P. MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9). PLoS ONE. 2016;11:e0166382 pubmed publisher
Zeltner N, Fattahi F, Dubois N, Saurat N, Lafaille F, Shang L, et al. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016;22:1421-1427 pubmed publisher
Maldonado M, Luu R, Ramos M, Nam J. ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation. Stem Cell Res. 2016;17:222-227 pubmed publisher
Kim H, Lee J, Heo H, Yang S, Ha K, Park W, et al. Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. Cell Biosci. 2016;6:50 pubmed publisher
Wang L, Qiu P, Jiao J, Hirai H, Xiong W, Zhang J, et al. Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage. Stem Cells. 2017;35:351-361 pubmed publisher
Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed publisher
Barruet E, Morales B, Lwin W, White M, Theodoris C, Kim H, et al. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016;7:115 pubmed publisher
Sato H, Idiris A, Miwa T, Kumagai H. Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells. Sci Rep. 2016;6:31063 pubmed publisher
Sala L, Yu Z, Ward van Oostwaard D, van Veldhoven J, Moretti A, Laugwitz K, et al. A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med. 2016;8:1065-81 pubmed publisher
Sun Y, Paşca S, Portmann T, Goold C, Worringer K, Guan W, et al. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. elife. 2016;5: pubmed publisher
Jiao J, Xiong W, Wang L, Yang J, Qiu P, Hirai H, et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. EBioMedicine. 2016;10:282-90 pubmed publisher
Horii M, Li Y, Wakeland A, Pizzo D, Nelson K, Sabatini K, et al. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016;113:E3882-91 pubmed publisher
Mah I, Soloff R, Izuhara A, Lakeland D, Wang C, Mariani F. Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation. Dev Biol. 2016;416:82-97 pubmed publisher
Kestens C, Siersema P, Offerhaus G, van Baal J. BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2. PLoS ONE. 2016;11:e0155754 pubmed publisher
Dou D, Calvanese V, Sierra M, Nguyen A, Minasian A, Saarikoski P, et al. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016;18:595-606 pubmed publisher
Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang H. Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016;12:465-78 pubmed publisher
Song I, Oh A, Kim J, Choi Y, Jeon Y, Ryu J, et al. The involvement of protein kinase C-ε in isoflurane induced preconditioning of human embryonic stem cell--derived Nkx2.5(+) cardiac progenitor cells. BMC Anesthesiol. 2016;16:13 pubmed publisher
Smith D, Glen K, Thomas R. Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation. Biotechnol Prog. 2016;32:215-23 pubmed publisher
Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, et al. Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells. 2016;34:93-101 pubmed publisher
Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, et al. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol. 2016;44:68-74.e1-10 pubmed publisher
Kim J, Kurie J, Ahn Y. BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells. Mol Cancer. 2015;14:173 pubmed publisher
Ray P, Chapman S. Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling. PLoS ONE. 2015;10:e0134702 pubmed publisher
Müller P, Doliva R, Busch M, Philippeit C, Stephan H, Dünker N. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. PLoS ONE. 2015;10:e0131467 pubmed publisher
Gerbin K, Yang X, Murry C, Coulombe K. Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts. PLoS ONE. 2015;10:e0131446 pubmed publisher
Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, et al. Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells. Stem Cells. 2015;33:2686-98 pubmed publisher
Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, et al. Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J Biol Chem. 2015;290:17239-49 pubmed publisher
Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G. Generation of articular chondrocytes from human pluripotent stem cells. Nat Biotechnol. 2015;33:638-45 pubmed publisher
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
Yang Y, Adachi K, Sheridan M, Alexenko A, Schust D, Schulz L, et al. Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. Proc Natl Acad Sci U S A. 2015;112:E2337-46 pubmed publisher
Tadeu A, Lin S, Hou L, Chung L, Zhong M, Zhao H, et al. Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. PLoS ONE. 2015;10:e0122493 pubmed publisher
Majumder A, Syed K, Joseph S, Scambler P, Dutta D. Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem. 2015;290:13053-63 pubmed publisher
Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, et al. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development. 2015;142:1528-41 pubmed publisher
Sugawa F, Araúzo Bravo M, Yoon J, Kim K, Aramaki S, Wu G, et al. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. EMBO J. 2015;34:1009-24 pubmed publisher
Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, et al. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS ONE. 2015;10:e0118670 pubmed publisher
Tsankov A, Gu H, Akopian V, Ziller M, Donaghey J, Amit I, et al. Transcription factor binding dynamics during human ES cell differentiation. Nature. 2015;518:344-9 pubmed publisher
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, et al. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest. 2015;125:1243-54 pubmed publisher
Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher
Wong A, Chin S, Xia S, Garner J, Bear C, Rossant J. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc. 2015;10:363-81 pubmed publisher
Lee J, Graham M, Collins T, Lee J, Hong S, Mcnicol A, et al. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells. 2015;33:1142-52 pubmed publisher
Nio Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, et al. Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology. 2015;156:1494-503 pubmed publisher
Wong S, Ulrich T, Deleyrolle L, MacKay J, Lin J, Martuscello R, et al. Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Cancer Res. 2015;75:1113-22 pubmed publisher
Göttle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, et al. Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci. 2015;35:906-19 pubmed publisher
Hu D, Young N, Li X, Xu Y, Hallgrímsson B, Marcucio R. A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Development. 2015;142:567-74 pubmed publisher
Malhotra R, Burke M, Martyn T, Shakartzi H, Thayer T, O Rourke C, et al. Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS ONE. 2015;10:e0117098 pubmed publisher
Song B, Fan Y, He W, Zhu D, Niu X, Wang D, et al. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. Stem Cells Dev. 2015;24:1053-65 pubmed publisher
Wu J, Fan Y, Tzanakakis E. Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells. Stem Cells Dev. 2015;24:892-903 pubmed publisher
Maury Y, Côme J, Piskorowski R, Salah Mohellibi N, Chevaleyre V, Peschanski M, et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol. 2015;33:89-96 pubmed publisher
Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, et al. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports. 2014;3:242-9 pubmed publisher
Dominguez A, Chiang H, Sukhwani M, Orwig K, Reijo Pera R. Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies. Sci Rep. 2014;4:6432 pubmed publisher
Shelton M, Metz J, Liu J, Carpenedo R, Demers S, Stanford W, et al. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Stem Cell Reports. 2014;3:516-29 pubmed publisher
Wile B, Ban K, Yoon Y, Bao G. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc. 2014;9:2411-24 pubmed publisher
Lim M, Ooi B, Jungebluth P, Sjöqvist S, Hultman I, Lemon G, et al. Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor. PLoS ONE. 2014;9:e107712 pubmed publisher
Cao Y, Slaney C, Bidwell B, Parker B, Johnstone C, Rautela J, et al. BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity. Cancer Res. 2014;74:5091-102 pubmed publisher
Lee R, Kim I, Han N, Yun S, Park K, Yoo K. Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep. 2014;4:6319 pubmed publisher
Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, et al. Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome. PLoS ONE. 2014;9:e102796 pubmed publisher
Josowitz R, Lu J, Falce C, D Souza S, Wu M, Cohen N, et al. Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression. PLoS ONE. 2014;9:e101316 pubmed publisher
Dambrot C, Braam S, Tertoolen L, Birket M, Atsma D, Mummery C. Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. J Cell Mol Med. 2014;18:1509-18 pubmed publisher
Ao Y, Mich Basso J, Lin B, Yang L. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE. 2014;9:e100417 pubmed publisher
Park C, Kim J, Kweon J, Son J, Lee J, Yoo J, et al. Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Proc Natl Acad Sci U S A. 2014;111:9253-8 pubmed publisher
Cabrera Sharp V, Read J, Richardson S, Kowalski A, Antczak D, Cartwright J, et al. SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion. Endocrinology. 2014;155:3054-64 pubmed publisher
Mann Z, Thiede B, Chang W, Shin J, May Simera H, Lovett M, et al. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun. 2014;5:3839 pubmed publisher
Chang C, Lai Y, Lamb L, Townes T. Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells. PLoS ONE. 2014;9:e97335 pubmed publisher
Jakobsen R, Østrup E, Zhang X, Mikkelsen T, Brinchmann J. Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE. 2014;9:e96615 pubmed publisher
Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, et al. Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm. Nat Commun. 2014;5:3678 pubmed publisher
Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, et al. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014;3:734-44 pubmed publisher
Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, et al. Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep. 2014;4:4646 pubmed publisher
Kim W, Zhu Y, Deng Q, Chin C, He C, Grieco A, et al. Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells. 2014;32:1503-14 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Watanabe H, Takayama K, Inamura M, Tachibana M, Mimura N, Katayama K, et al. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS ONE. 2014;9:e90791 pubmed publisher
Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell. 2014;14:342-56 pubmed publisher
Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, et al. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS ONE. 2014;9:e89135 pubmed publisher
Lin I, Chiu F, Yeang C, Chen H, Chuang C, Yang S, et al. Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports. 2014;2:189-204 pubmed publisher
Ferrell P, Hexum M, Kopher R, Lepley M, Gussiaas A, Kaufman D. Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev. 2014;23:1355-63 pubmed publisher
Ronaghi M, Nasr M, Ealy M, Durruthy Durruthy R, Waldhaus J, Diaz G, et al. Inner ear hair cell-like cells from human embryonic stem cells. Stem Cells Dev. 2014;23:1275-84 pubmed publisher
Yang R, Zheng Y, Burrows M, Liu S, Wei Z, Nace A, et al. Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. Nat Commun. 2014;5:3071 pubmed publisher
Fang F, Wasserman S, Torres Vazquez J, Weinstein B, Cao F, Li Z, et al. The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function. J Cell Sci. 2014;127:1428-40 pubmed publisher
Takebe T, Zhang R, Koike H, Kimura M, Yoshizawa E, Enomura M, et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc. 2014;9:396-409 pubmed publisher
Culbert A, Chakkalakal S, Theosmy E, Brennan T, Kaplan F, Shore E. Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification. Stem Cells. 2014;32:1289-300 pubmed publisher
Kohler E, Wary K, Li F, Chatterjee I, Urao N, Toth P, et al. Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells. PLoS ONE. 2013;8:e85549 pubmed publisher
Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014;25:1211-25 pubmed publisher
Goyal A, CHAVEZ S, Reijo Pera R. Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies. PLoS ONE. 2013;8:e82838 pubmed publisher
Xue R, Wan Y, Zhang S, Zhang Q, Ye H, Li Y. Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Am J Physiol Endocrinol Metab. 2014;306:E363-72 pubmed publisher
Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 2014;14:53-67 pubmed publisher
Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, et al. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports. 2013;1:322-35 pubmed publisher
Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, et al. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014;134:1246-1254 pubmed publisher
Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed publisher
Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, et al. CCAAT/enhancer binding protein-mediated regulation of TGF? receptor 2 expression determines the hepatoblast fate decision. Development. 2014;141:91-100 pubmed publisher
Srikanth M, Kim J, Das S, Kessler J. BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol Cancer Res. 2014;12:283-94 pubmed publisher
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. elife. 2013;2:e00940 pubmed publisher
Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, et al. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler Thromb Vasc Biol. 2014;34:152-9 pubmed publisher
Turnbull I, Karakikes I, Serrao G, Backeris P, Lee J, Xie C, et al. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB J. 2014;28:644-54 pubmed publisher
Jiang D, Aguiar R. MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-?1/SMAD5 signaling module. Blood. 2014;123:86-93 pubmed publisher
Mahadevan S, Wen S, Wan Y, Peng H, Otta S, Liu Z, et al. NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation. Hum Mol Genet. 2014;23:706-16 pubmed publisher
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, et al. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood. 2013;122:3767-77 pubmed publisher
Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, et al. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013;13:459-70 pubmed publisher
Fujiwara T, Ikeda T, Nagasaka Y, Okitsu Y, Katsuoka Y, Fukuhara N, et al. A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS ONE. 2013;8:e75568 pubmed publisher
Lorda Diez C, Montero J, Choe S, Garcia Porrero J, Hurle J. Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res. 2014;29:735-48 pubmed publisher
Liang P, Lan F, Sanchez Freire V, Simmons C, Gong T, Sharma A, et al. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013;128:S3-13 pubmed publisher
Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, et al. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors. Oncogene. 2014;33:3803-11 pubmed publisher
Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, et al. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica. 2014;99:19-27 pubmed publisher
Talavera Adame D, Gupta A, Kurtovic S, Chaiboonma K, Arumugaswami V, Dafoe D. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev. 2013;22:3252-60 pubmed publisher
Duggal G, Heindryckx B, Warrier S, O Leary T, Van der Jeught M, Lierman S, et al. Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential. Stem Cells Dev. 2013;22:3141-55 pubmed publisher
Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, et al. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013;12:748-60 pubmed publisher
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, et al. A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain. 2013;6:19 pubmed publisher
Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, et al. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J. 2013;27:2977-87 pubmed publisher
Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L, et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev Cell. 2013;25:69-80 pubmed publisher
Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Höing S, et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE. 2013;8:e59252 pubmed publisher
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, et al. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A. 2013;110:E1426-35 pubmed publisher
Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, et al. Identification of small molecule activators of BMP signaling. PLoS ONE. 2013;8:e59045 pubmed publisher
Liang P, Lan F, Lee A, Gong T, Sanchez Freire V, Wang Y, et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 2013;127:1677-91 pubmed publisher
Chou H, Lai D, Huang C, McLennan I, Wang H, Wang P. BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS ONE. 2013;8:e58441 pubmed publisher
Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, et al. Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest. 2013;93:450-61 pubmed publisher
Pick M, Azzola L, Osborne E, Stanley E, Elefanty A. Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium. PLoS ONE. 2013;8:e55530 pubmed publisher
White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, et al. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells. 2013;31:92-103 pubmed publisher
Huse K, Bakkebø M, Walchli S, Oksvold M, Hilden V, Forfang L, et al. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE. 2012;7:e46117 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Pereira P, Dobreva M, Maas E, Cornelis F, Moya I, Umans L, et al. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development. 2012;139:3343-54 pubmed publisher
Aad P, Echternkamp S, Sypherd D, Schreiber N, Spicer L. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod. 2012;87:79 pubmed publisher
Kawabata K, Ehata S, Komuro A, Takeuchi K, Miyazono K. TGF-?-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20. Oncogene. 2013;32:2096-106 pubmed publisher
Kim M, Yoon S, Lee S, Ha S, Kim H, Kim J, et al. Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE. 2012;7:e35100 pubmed publisher
Yao Y, Jumabay M, Ly A, Radparvar M, Wang A, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012;119:5037-47 pubmed publisher
Cheung C, Bernardo A, Trotter M, Pedersen R, Sinha S. Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol. 2012;30:165-73 pubmed publisher
Joubin K, Richardson A, Novoa N, Tu E, Tomishima M. The endothelial cell line bEnd.3 maintains human pluripotent stem cells. Stem Cells Dev. 2012;21:2312-21 pubmed publisher
Silk K, Silk J, Ichiryu N, Davies T, Nolan K, Leishman A, et al. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther. 2012;19:1035-40 pubmed publisher
Wong R, Pollan S, Fong H, Ibrahim A, Smith E, Ho M, et al. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Stem Cells. 2011;29:1517-27 pubmed publisher
Huse K, Bakkebø M, Oksvold M, Forfang L, Hilden V, Stokke T, et al. Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur J Immunol. 2011;41:3135-45 pubmed publisher
Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff A. Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma. Lab Invest. 2011;91:1615-23 pubmed publisher
Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, et al. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE. 2011;6:e22261 pubmed publisher
Rochira J, Matluk N, Adams T, Karaczyn A, Oxburgh L, Hess S, et al. A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-?B activation and apoptosis in P19 cells. PLoS ONE. 2011;6:e20659 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Davis Dusenbery B, Chan M, Reno K, Weisman A, Layne M, Lagna G, et al. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011;286:28097-110 pubmed publisher
Geens M, Sermon K, Van De Velde H, Tournaye H. Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J Assist Reprod Genet. 2011;28:471-80 pubmed publisher
Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, et al. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res. 2011;21:579-87 pubmed publisher
Klim J, Li L, Wrighton P, Piekarczyk M, Kiessling L. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods. 2010;7:989-94 pubmed publisher
Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, et al. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood. 2011;117:839-47 pubmed publisher
Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed publisher
Stewart A, Guan H, Yang K. BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway. J Cell Physiol. 2010;223:658-66 pubmed publisher
Rai D, Kim S, McKeller M, Dahia P, Aguiar R. Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A. 2010;107:3111-6 pubmed publisher
Chng Z, Teo A, Pedersen R, Vallier L. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell. 2010;6:59-70 pubmed publisher
Lanner F, Lee K, Sohl M, Holmborn K, Yang H, Wilbertz J, et al. Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells. 2010;28:191-200 pubmed publisher
Grcevic D, Kusec R, Kovacic N, Lukić A, Lukic I, Ivcevic S, et al. Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leuk Res. 2010;34:742-51 pubmed publisher
Sugiura K, Su Y, Li Q, Wigglesworth K, Matzuk M, Eppig J. Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod. 2009;81:833-41 pubmed publisher
Ye L, Chang J, Lin C, Sun X, Yu J, Kan Y. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A. 2009;106:9826-30 pubmed publisher
Sellers D, Maris D, Horner P. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J Neurosci. 2009;29:6722-33 pubmed publisher
Tanno T, Porayette P, Sripichai O, Noh S, Byrnes C, Bhupatiraju A, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009;114:181-6 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Kelly M, Hirschi K. Signaling hierarchy regulating human endothelial cell development. Arterioscler Thromb Vasc Biol. 2009;29:718-24 pubmed publisher
Stevens K, Pabon L, Muskheli V, Murry C. Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A. 2009;15:1211-22 pubmed publisher
Bernardo A, Cho C, Mason S, Docherty H, Pedersen R, Vallier L, et al. Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells. 2009;27:341-51 pubmed publisher
Yao Y, Shao E, Jumabay M, Shahbazian A, Ji S, BOSTROM K. High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol. 2008;28:2266-74 pubmed publisher
Boswell B, Overbeek P, Musil L. Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev Biol. 2008;324:202-12 pubmed publisher
Levine A, Levine Z, Brivanlou A. GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev Biol. 2009;325:43-8 pubmed publisher
Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, et al. Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem. 2008;283:24991-5002 pubmed publisher
Kane R, Godson C, O Brien C. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis. 2008;14:1138-48 pubmed
Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, et al. Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells. J Cell Physiol. 2008;217:261-80 pubmed publisher
Desbordes S, Placantonakis D, Ciro A, Socci N, Lee G, Djaballah H, et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2008;2:602-12 pubmed publisher
Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, et al. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci. 2008;38:245-58 pubmed publisher
Yang L, Soonpaa M, Adler E, Roepke T, Kattman S, Kennedy M, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008;453:524-8 pubmed publisher
Boswell B, Lein P, Musil L. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol Biol Cell. 2008;19:2631-41 pubmed publisher
Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky R, et al. Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell. 2008;2:345-55 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci N, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152-65 pubmed publisher
Anderson B, Christiansen S, McLoon L. Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus. Invest Ophthalmol Vis Sci. 2008;49:221-9 pubmed publisher
Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, et al. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood. 2008;111:1933-41 pubmed
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72 pubmed
Southwood M, Jeffery T, Yang X, Upton P, Hall S, Atkinson C, et al. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J Pathol. 2008;214:85-95 pubmed
Zode G, Clark A, Wordinger R. Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2007;48:5058-67 pubmed
Kavanagh K, Evans A, Jernvall J. Predicting evolutionary patterns of mammalian teeth from development. Nature. 2007;449:427-32 pubmed
Zilberberg L, Ten Dijke P, Sakai L, Rifkin D. A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol. 2007;8:41 pubmed
Fuller M, DeChant A, Rothstein B, Caprariello A, Wang R, Hall A, et al. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann Neurol. 2007;62:288-300 pubmed
Stavridis M, Lunn J, Collins B, Storey K. A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development. 2007;134:2889-94 pubmed
Tesar P, Chenoweth J, Brook F, Davies T, Evans E, Mack D, et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature. 2007;448:196-9 pubmed
Lin L, Valore E, Nemeth E, Goodnough J, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-9 pubmed
Rajesh D, Chinnasamy N, Mitalipov S, Wolf D, Slukvin I, Thomson J, et al. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells. 2007;25:490-9 pubmed
Knobloch J, Shaughnessy J, Ruther U. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J. 2007;21:1410-21 pubmed
Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, et al. Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood. 2007;109:1834-40 pubmed
Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, et al. Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 2006;133:4463-73 pubmed
Bonafede A, Kohler T, Rodriguez Niedenführ M, Brand Saberi B. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev Biol. 2006;299:330-44 pubmed
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, et al. Multipotent adult progenitor cells from swine bone marrow. Stem Cells. 2006;24:2355-66 pubmed
Kiyono M, Shibuya M. Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene. 2006;25:7131-7 pubmed
Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, et al. Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells. 2006;24:2014-22 pubmed
Spicer L, Aad P, Allen D, Mazerbourg S, Hsueh A. Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. J Endocrinol. 2006;189:329-39 pubmed
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed
Yao S, Chen S, Clark J, Hao E, Beattie G, Hayek A, et al. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A. 2006;103:6907-12 pubmed
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, et al. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development. 2005;132:3731-42 pubmed
Ng R, Gurdon J. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc Natl Acad Sci U S A. 2005;102:1957-62 pubmed
Pierre A, Pisselet C, Dupont J, Mandon Pepin B, Monniaux D, Monget P, et al. Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells. J Mol Endocrinol. 2004;33:805-17 pubmed
Chen B, Blair D, Plisov S, Vasiliev G, Perantoni A, Chen Q, et al. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J Immunol. 2004;173:5914-7 pubmed
Marklund M, Sjödal M, Beehler B, Jessell T, Edlund T, Gunhaga L. Retinoic acid signalling specifies intermediate character in the developing telencephalon. Development. 2004;131:4323-32 pubmed
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, et al. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene. 2004;331:17-31 pubmed
Althini S, Usoskin D, Kylberg A, Kaplan P, Ebendal T. Blocked MAP kinase activity selectively enhances neurotrophic growth responses. Mol Cell Neurosci. 2004;25:345-54 pubmed
Binnerts M, Wen X, Canté Barrett K, Bright J, Chen H, Asundi V, et al. Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem Biophys Res Commun. 2004;315:272-80 pubmed
Wakamatsu Y, Endo Y, Osumi N, Weston J. Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development. Dev Dyn. 2004;229:74-86 pubmed
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, et al. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol. 2003;23:5664-79 pubmed
Ahn S, Kim C, Suk H, Lee Y, Choi S, Chai J, et al. Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. J Periodontol. 2003;74:787-97 pubmed
Viti J, Gulacsi A, Lillien L. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci. 2003;23:5919-27 pubmed
Fischer A, Viebahn C, Blum M. FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr Biol. 2002;12:1807-16 pubmed
image
image 1 :
R&D Systems 314-BP-010 image 1
product information
brand :
R&D Systems
MasterCode :
314-BP
SKU :
314-BP-010
product name :
Recombinant Human BMP-4 Protein
Description :
The BMP-4 Protein from 314-BP-010 is derived from NS0-derived Recombinant Human BMP-4 Protein. The BMP-4 Protein has been validated for the following applications: Q53XC5.
target :
BMP-4
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug, 500 ug, 1 mg)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
19-24 kDa, reducing conditions 35-41 kDa, non-reducing conditions
theoretical molecular weight :
13 kDa (monomer)
gene symbol :
BMP4
details of functionality :
Measured by its ability to induce BMP responsive SEAP reporter activity in HEK293 human embryonic kidney cells. The ED50 for this effect is 0.70-7.00 ng/mL. Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al . (2004) Biochem. Biophys. Res. Commun. 315(2) :272. The ED50 for this effect is 3.00-30.0 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q53XC5
applications :
Bioactivity
source :
NS0-derived Recombinant Human BMP-4 Protein
extended description :
An economically priced, E.coli-expressed version now available!
USD :
416 USD
product details :
An economically priced, E.coli-expressed version now available!
alt names :
BMP2B, BMP-2B, BMP2B1, BMP2BMCOPS6, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, ZYME
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.