Recombinant Human COMP His-tag Protein, CF | R&D Systems 3134-CPB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human COMP His-tag Protein, CF

catalog :

3134-CPB-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Sun L, Wang Y, Wang L, Yao B, Chen T, Li Q, et al. Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP. J Exp Clin Cancer Res. 2019;38:170 pubmed publisher
Li Q, Wang C, Wang Y, Sun L, Liu Z, Wang L, et al. HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. J Exp Clin Cancer Res. 2018;37:231 pubmed publisher
Raj A, Wang M, Liu C, Ali L, Karlsson N, Claesson P, et al. Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin. J Colloid Interface Sci. 2017;495:200-206 pubmed publisher
Jeschke A, Bonitz M, Simon M, Peters S, Baum W, Schett G, et al. Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage Thickness. PLoS ONE. 2015;10:e0144272 pubmed publisher

image

image 1 :

Recombinant Human COMP His-tag Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3134-CPB

SKU :

3134-CPB-050

product name :

Recombinant Human COMP His-tag Protein, CF

Description :

The Recombinant Human COMP His-tag Protein, CF from R&D Systems is derived from NS0. The Recombinant Human COMP His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

COMP/Thrombospondin-5

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS and NaCl with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

106-118 kDa, reducing conditions

theoretical molecular weight :

81.8 kDa

details of functionality :

Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. Recombinant Human COMP/Thrombospondin-5 immobilized at 10 µg/mL (100 µL/well) will induce more than 40% of ATDC-5 cell adhesion.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P49747

applications :

Bioactivity

source :

NS0-derived Recombinant Human COMP His-tag Protein

USD :

423 USD

alt names :

cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia1, multiple), cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia1, multiple), EDM1, EPD1, MED, MEDMGC131819, MGC149768, PSACH, pseudoachondroplasia (epiphyseal dysplasia 1, multiple), THBS5, Thrombospondin5, Thrombospondin-5, TSP5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage