Recombinant Human Kallikrein 12 Protein, CF | R&D Systems 3095-SE-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Kallikrein 12 Protein, CF

catalog :

3095-SE-010

quantity :

10 ug

price :

541 USD

citations: 6

Reference
Straus M, Whittaker G. A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site. PLoS ONE. 2017;12:e0174827 pubmed publisher
Kryza T, Achard C, Parent C, Marchand Adam S, Guillon Munos A, Iochmann S, et al. Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway. FASEB J. 2014;28:740-51 pubmed publisher
Guillon Munos A, Oikonomopoulou K, Michel N, Smith C, Petit Courty A, Canepa S, et al. Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors. J Biol Chem. 2011;286:25505-18 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher
Yoon H, Laxmikanthan G, Lee J, Blaber S, Rodriguez A, Kogot J, et al. Activation profiles and regulatory cascades of the human kallikrein-related peptidases. J Biol Chem. 2007;282:31852-64 pubmed
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed

product information

master code :

3095-SE

SKU :

3095-SE-010

product name :

Recombinant Human Kallikrein 12 Protein, CF

unit size :

10 ug

description :

The Recombinant Human Kallikrein 12 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 12 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Kallikrein 12

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in MES, NaCl and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

37 kDa, reducing conditions

theoretical molecular weight :

26 kDa

gene symbol :

KLK12

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011 ). The specific activity is 4,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_665901

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived human Kallikrein 12 protein Ala18-Asn248, with a C-terminal 10-His tag

source short :

NS0

USD :

541 USD

alt names :

DKFZp686H1078, EC 3.4.21, EC 3.4.21.-, kallikrein 12, Kallikrein-like protein 5, kallikrein-related peptidase 12, KLK12, KLK-L5, KLKL5kallikrein-12, KLK-L5MGC42603

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.