Recombinant Human IL-12/IL-23 p40 Monomer Protein | R&D Systems 309-IL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-12/IL-23 p40 Monomer Protein

catalog :

309-IL

quantity :

10 ug

price :

209 USD

citations: 5

Reference
Garnier P, Mummery R, Forster M, Mulloy B, Gibbs R, Rider C. The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit. Cytokine. 2018;110:159-168 pubmed publisher
Abdi K, Singh N, Spooner E, Kessler B, Radaev S, Lantz L, et al. Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly. J Immunol. 2014;192:6028-36 pubmed publisher
Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, et al. Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J Allergy Clin Immunol. 2006;118:354-60 pubmed
Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed
Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, et al. Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. J Neuroimmunol. 2006;175:169-75 pubmed

product information

brand :

R&D Systems

master code :

309-IL

SKU :

309-IL-010

product name :

Recombinant Human IL-12/IL-23 p40 Monomer Protein

description :

The Recombinant Human IL-12/IL-23 p40 Monomer Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human IL-12/IL-23 p40 Monomer Protein has been validated for the following applications: Bioactivity.

target :

IL-12/IL-23 p40

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

40 kDa, reducing conditions

theoretical molecular weight :

34.7 kDa

gene symbol :

IL12B

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human IL-12 R beta 1 Fc Chimera (Catalog # 839-B1 ) is immobilized at 1 µg/mL (100 µL/well), the concentration of Recombinant Human IL-12/IL-23 p40 Monomer that produces 50% of the optimal binding response is 1-6 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

309-IL

accessionNumbers :

P29460

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human IL-12/IL-23 p40 protein Ile23-Ser328

2020 USD :

209

2021 USD :

209 USD

alt names :

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.