Recombinant Human IL-12/IL-23 p40 Monomer Protein | R&D Systems 309-IL-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-12/IL-23 p40 Monomer Protein

catalog :

309-IL-010

quantity :

10 ug

price :

249 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Mondal S, Kundu M, Jana M, Roy A, Rangasamy S, Modi K, et al. IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE. Proc Natl Acad Sci U S A. 2020;117:21557-21567 pubmed publisher
Garnier P, Mummery R, Forster M, Mulloy B, Gibbs R, Rider C. The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit. Cytokine. 2018;110:159-168 pubmed publisher
Abdi K, Singh N, Spooner E, Kessler B, Radaev S, Lantz L, et al. Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly. J Immunol. 2014;192:6028-36 pubmed publisher
Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, et al. Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J Allergy Clin Immunol. 2006;118:354-60 pubmed
Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed
Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, et al. Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. J Neuroimmunol. 2006;175:169-75 pubmed

image

image 1 :

Recombinant Human IL-12/IL-23 p40 Monomer Protein Binding Activity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

309-IL

SKU :

309-IL-010

product name :

Recombinant Human IL-12/IL-23 p40 Monomer Protein

Description :

The Recombinant Human IL-12/IL-23 p40 Monomer Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human IL-12/IL-23 p40 Monomer Protein has been validated for the following applications: Bioactivity.

target :

IL-12/IL-23 p40

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

40 kDa, reducing conditions

theoretical molecular weight :

34.7 kDa

gene symbol :

IL12B

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human IL-12 R beta 1 Fc Chimera (Catalog # 839-B1 ) is immobilized at 1 µg/mL (100 µL/well), the concentration of Recombinant Human IL-12/IL-23 p40 Monomer that produces 50% of the optimal binding response is 1-6 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P29460

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human IL-12/IL-23 p40 Monomer Protein

USD :

249 USD

alt names :

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage