Mayuranathan T, Newby G, Feng R, Yao Y, Mayberry K, Lazzarotto C, et al. Potent and uniform fetal hemoglobin induction via base editing. Nat Genet. 2023;55:1210-1220 pubmed publisher

Cabral Piccin M, Papagno L, Lahaye X, Perdomo Celis F, Volant S, White E, et al. Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection. EBioMedicine. 2023;91:104557 pubmed publisher

Li S, Wang C, Montel Hagen A, Chen H, Lopez S, Zhou O, et al. Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. Cell Rep. 2023;42:112241 pubmed publisher

Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, et al. Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods. 2022;2:100317 pubmed publisher

Michaels Y, Edgar J, Major M, Castle E, Zimmerman C, Yin T, et al. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells. Sci Adv. 2022;8:eabn5522 pubmed publisher

Jing R, Scarfò I, Najia M, Lummertz da Rocha E, Han A, Sanborn M, et al. EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity. Cell Stem Cell. 2022;29:1181-1196.e6 pubmed publisher

Sahoo S, Pastor V, Goodings C, Voss R, Kozyra E, Szvetnik A, et al. Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes. Nat Med. 2021;27:1806-1817 pubmed publisher

Newby G, Yen J, Woodard K, Mayuranathan T, Lazzarotto C, Li Y, et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature. 2021;595:295-302 pubmed publisher

Reid J, Golubeva D, Boyd A, Hollands C, Henly C, Orlando L, et al. Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients. Cell Rep. 2021;34:108845 pubmed publisher

Wang T, Pine A, Kotini A, Yuan H, Zamparo L, Starczynowski D, et al. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell Stem Cell. 2021;28:1074-1089.e7 pubmed publisher

Nagel S, Pommerenke C, Meyer C, MacLeod R, Drexler H. Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia. PLoS ONE. 2020;15:e0240120 pubmed publisher

Wesely J, Kotini A, Izzo F, Luo H, Yuan H, Sun J, et al. Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells. Cell Rep. 2020;31:107688 pubmed publisher

Leonard A, Yapundich M, Nassehi T, Gamer J, Drysdale C, Haro Mora J, et al. Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice. Mol Ther Methods Clin Dev. 2019;15:430-437 pubmed publisher

Charrier S, Lagresle Peyrou C, Poletti V, Rothe M, Cédrone G, Gjata B, et al. Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID. Mol Ther Methods Clin Dev. 2019;15:232-245 pubmed publisher

Grajcarek J, Monlong J, Nishinaka Arai Y, Nakamura M, Nagai M, Matsuo S, et al. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations. Nat Commun. 2019;10:4856 pubmed publisher

Uchida N, Hsieh M, Raines L, Haro Mora J, Demirci S, Bonifacino A, et al. Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders. Nat Commun. 2019;10:4479 pubmed publisher

Rogers G, Chen H, Morales H, Cannon P. Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break. Mol Ther. 2019;27:1726-1736 pubmed publisher

Ly M, Rentas S, Vujovic A, Wong N, Moreira S, Xu J, et al. Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance. Cancer Res. 2019;79:5799-5811 pubmed publisher

McKenzie M, Ghisi M, Oxley E, Ngo S, Cimmino L, Esnault C, et al. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell. 2019;25:258-272.e9 pubmed publisher

Ohta R, Sugimura R, Niwa A, Saito M. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp. 2019;: pubmed publisher

Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, et al. CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica. 2019;: pubmed publisher

Ruiz Gutierrez M, Bölükbaşı Ö, Alexe G, Kotini A, Ballotti K, Joyce C, et al. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 2019;5: pubmed publisher

Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, et al. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I. Stem Cell Res. 2019;36:101406 pubmed publisher

Uchida N, Nassehi T, Drysdale C, Gamer J, Yapundich M, Demirci S, et al. High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2. Mol Ther Methods Clin Dev. 2019;13:187-196 pubmed publisher

Potirat P, Wattanapanitch M, Viprakasit V, Kheolamai P, Issaragrisil S. An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling. Stem Cell Res. 2019;34:101344 pubmed publisher

Tremblay C, Saw J, Chiu S, Wong N, Tsyganov K, Ghotb S, et al. Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells. Nat Commun. 2018;9:3535 pubmed publisher

Camgoz A, Paszkowski Rogacz M, Satpathy S, Wermke M, Hamann M, von Bonin M, et al. STK3 is a therapeutic target for a subset of acute myeloid leukemias. Oncotarget. 2018;9:25458-25473 pubmed publisher

Crawford L, Kim J, Collins McMillen D, Lee B, Landais I, Held C, et al. Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation. MBio. 2018;9: pubmed publisher

Cesana M, Guo M, Cacchiarelli D, Wahlster L, Barragan J, Doulatov S, et al. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Cell Stem Cell. 2018;22:575-588.e7 pubmed publisher

Zheng S, Papalexi E, Butler A, STEPHENSON W, Satija R. Molecular transitions in early progenitors during human cord blood hematopoiesis. Mol Syst Biol. 2018;14:e8041 pubmed publisher

Palau A, Garz A, Diesch J, Zwick A, Malinverni R, Valero V, et al. Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes. Oncotarget. 2017;8:115002-115017 pubmed publisher

Carretta M, Brouwers Vos A, Bosman M, Horton S, Martens J, Vellenga E, et al. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. PLoS ONE. 2017;12:e0189102 pubmed publisher

Laiño J, Wangorsch A, Blanco F, Wolfheimer S, Krause M, Flaczyk A, et al. Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice. J Immunol Res. 2017;2017:7983217 pubmed publisher

Jiang X, Hawkins J, Lee J, Lizama C, Bos F, Zape J, et al. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017;8:128 pubmed publisher

Kotini A, Chang C, Chow A, Yuan H, Ho T, Wang T, et al. Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia. Cell Stem Cell. 2017;20:315-328.e7 pubmed publisher

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée V, Hébert J, et al. A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens. Blood Cancer J. 2017;7:e529 pubmed publisher

Nakagawa N, Barron L, Gomez I, Johnson B, Roach A, Kameoka S, et al. Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease. JCI Insight. 2016;1:e87446 pubmed publisher

Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, et al. Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer. Stem Cells. 2016;34:93-101 pubmed publisher

Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, et al. Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML). PLoS ONE. 2015;10:e0122983 pubmed publisher

Lee J, Graham M, Collins T, Lee J, Hong S, Mcnicol A, et al. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells. 2015;33:1142-52 pubmed publisher

Matsuoka Y, Nakatsuka R, Sumide K, Kawamura H, Takahashi M, Fujioka T, et al. Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells. Stem Cells. 2015;33:1554-65 pubmed publisher

Gerby B, Tremblay C, Tremblay M, Rojas Sutterlin S, Herblot S, Hébert J, et al. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet. 2014;10:e1004768 pubmed publisher

Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, et al. Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques. Stem Cells. 2015;33:91-100 pubmed publisher

Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, et al. Small-molecule inhibitor of glycogen synthase kinase 3β 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice. Stem Cells Dev. 2015;24:724-36 pubmed publisher

Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, et al. Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol. 2014;166:435-48 pubmed publisher

Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, et al. Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells. Cell Stem Cell. 2014;14:486-499 pubmed publisher

Reynolds C, Roderick J, LaBelle J, Bird G, Mathieu R, Bodaar K, et al. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2014;28:1819-27 pubmed publisher

Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells. 2014;32:1337-46 pubmed publisher

Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, et al. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood. 2014;123:1239-49 pubmed publisher

Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, et al. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014;134:1246-1254 pubmed publisher

Osaki Y, Yokohama A, Saito A, Tahara K, Yanagisawa K, Ogawa Y, et al. Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm?. PLoS ONE. 2013;8:e81722 pubmed publisher

Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein I, et al. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood. 2014;123:650-8 pubmed publisher

Berger A, Frelin C, Shah D, Benveniste P, Herrington R, Gerard N, et al. Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency. PLoS ONE. 2013;8:e58787 pubmed publisher

Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, et al. Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells. 2013;31:666-81 pubmed publisher

Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher

Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, et al. A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE. 2011;6:e22261 pubmed publisher

Ye L, Chang J, Lin C, Sun X, Yu J, Kan Y. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A. 2009;106:9826-30 pubmed publisher

Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, et al. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp Hematol. 2008;36:1035-46 pubmed publisher

Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, et al. Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions. Exp Hematol. 2008;36:235-43 pubmed publisher

Srivastava A, Nedelcu E, Esmaeli Azad B, Mishra R, Carrier E. Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells. 2007;25:1456-61 pubmed

Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, et al. Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells. 2006;24:2014-22 pubmed

Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, et al. Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp Hematol. 2006;34:760-9 pubmed

Kahl C, Tarantal A, Lee C, Jimenez D, Choi C, Pepper K, et al. Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector. Exp Hematol. 2006;34:369-81 pubmed

Drouet M, Mathieu J, Grenier N, Multon E, Sotto J, Herodin F. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Stem Cells. 1999;17:273-85 pubmed