product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Thrombospondin-1 Protein, CF
catalog :
3074-TH-050
quantity :
50 ug
price :
453 USD
more info or order :
R&D Systems product webpage
citations: 23
Reference
Touhami S, B xe9 guier F, Yang T, Augustin S, Roubeix C, Blond F, et al. Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently. Int J Mol Sci. 2022;23: pubmed publisher
Shibuya M, Matsui H, Sasagawa T, Nagamatsu T. A simple detection method for the serum sFLT1 protein in preeclampsia. Sci Rep. 2021;11:20613 pubmed publisher
Yao M, Sturdivant J, Ebrahimi A, Ganguly S, Elbayoumi T. Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models. Biomedicines. 2021;9: pubmed publisher
Lie S, Vieira B, Arruda S, Simões M, Ashander L, Furtado J, et al. Molecular Basis of The Retinal Pigment Epithelial Changes That Characterize The Ocular Lesion in Toxoplasmosis. Microorganisms. 2019;7: pubmed publisher
Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed publisher
Ojha A, Bhasym A, Mukherjee S, Annarapu G, Bhakuni T, Akbar I, et al. Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine. 2019;39:332-347 pubmed publisher
Inana G, Murat C, An W, Yao X, Harris I, Cao J. RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. J Transl Med. 2018;16:63 pubmed publisher
Kim D, Lim H, Lee D, Choi S, Oh W, Yang Y, et al. Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer's disease model. Sci Rep. 2018;8:354 pubmed publisher
Bibes R, Gobron S, Vincent F, Mélin C, Vedrenne N, Perraud A, et al. SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma. Oncotarget. 2017;8:85969-85983 pubmed publisher
Endt K, Goepfert J, Omlin A, Athanasiou A, Tennstedt P, Guenther A, et al. Development and clinical testing of individual immunoassays for the quantification of serum glycoproteins to diagnose prostate cancer. PLoS ONE. 2017;12:e0181557 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Zhai J, Liu J, Cheng X, Li S, Hong Y, Sun K, et al. Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E2 Synthesis and Inhibiting Thrombospondin-1 (TSP-1). Sci Rep. 2017;7:3245 pubmed publisher
Torres A, Gubbiotti M, Iozzo R. Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem. 2017;292:5055-5069 pubmed publisher
Mikuła Pietrasik J, Uruski P, Sosińska P, Maksin K, Piotrowska Kempisty H, Kucińska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Hsieh F, Turner L, Bolla J, Robinson C, Lavstsen T, Higgins M. The structural basis for CD36 binding by the malaria parasite. Nat Commun. 2016;7:12837 pubmed publisher
Toda M, Ueno M, Yamada J, Hiraga A, Tanaka H, Schlötzer Schrehardt U, et al. The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components. Invest Ophthalmol Vis Sci. 2016;57:4599-605 pubmed publisher
Maimaitiyiming H, Zhou Q, Wang S. Thrombospondin 1 Deficiency Ameliorates the Development of Adriamycin-Induced Proteinuric Kidney Disease. PLoS ONE. 2016;11:e0156144 pubmed publisher
Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, et al. Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein. J Biol Chem. 2015;290:8975-86 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, et al. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. 2011;208:1083-92 pubmed publisher
Peterson J, Zurakowski D, Italiano J, Michel L, Fox L, Klement G, et al. Normal ranges of angiogenesis regulatory proteins in human platelets. Am J Hematol. 2010;85:487-93 pubmed publisher
Lee Y, Koch M, Karl D, Torres Collado A, Fernando N, Rothrock C, et al. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer Res. 2010;70:948-56 pubmed publisher
Hyder S, Liang Y, Wu J. Estrogen regulation of thrombospondin-1 in human breast cancer cells. Int J Cancer. 2009;125:1045-53 pubmed publisher
product information
brand :
R&D Systems
master code :
3074-TH
SKU :
3074-TH-050
product name :
Recombinant Human Thrombospondin-1 Protein, CF
description :
The Recombinant Human Thrombospondin-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Thrombospondin-1 Protein, CF has been validated for the following applications: Bioactivity.
target :
Thrombospondin-1
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in TBS, NaCl, and Trehalose.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
135-165 kDa, reducing conditions
theoretical molecular weight :
129 kDa
gene symbol :
THBS1
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human VEGF (Catalog # 8147-VE/CF) is coated at 1.00 µg/mL (100 µL/well), it binds to Recombinant Human Thrombospondin-1. The ED50 for this binding is 100-600 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P07996-1
applications :
Bioactivity
source :
NS0-derived Recombinant Human Thrombospondin-1 Protein, CF
USD :
431
USD 2023 :
453 USD
alt names :
THBS, THBS1, THBS-1, thrombospondin 1, Thrombospondin1, thrombospondin-1p180, TSP-1, TSP1thrombospondin-1, TSPTSP-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.