Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF | R&D Systems 306-IR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF

catalog :

306-IR-050

quantity :

50 ug

price :

434 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Hehenkamp P, Hoffmann M, Kummer S, Reinauer C, D xf6 ing C, F xf6 rtsch K, et al. Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes. Eur J Immunol. 2021;51:3214-3227 pubmed publisher
Al Mossawi H, Yager N, Taylor C, Lau E, Danielli S, de Wit J, et al. Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nat Commun. 2019;10:4575 pubmed publisher
Seyfarth J, Lundtoft C, Förtsch K, Ahlert H, Rosenbauer J, Baechle C, et al. Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes. Pediatr Diabetes. 2018;19:955-962 pubmed publisher
Lundtoft C, Afum Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, et al. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. PLoS Pathog. 2017;13:e1006425 pubmed publisher
GALARZA MUNOZ G, Briggs F, Evsyukova I, Schott Lerner G, Kennedy E, Nyanhete T, et al. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell. 2017;169:72-84.e13 pubmed publisher
Poiret T, Rane L, Remberger M, Omazic B, Gustafsson Jernberg A, Vudattu N, et al. Reduced plasma levels of soluble interleukin-7 receptor during graft-versus-host disease (GVHD) in children and adults. BMC Immunol. 2014;15:25 pubmed publisher
Venet F, Foray A, Villars Méchin A, Malcus C, Poitevin Later F, Lepape A, et al. IL-7 restores lymphocyte functions in septic patients. J Immunol. 2012;189:5073-81 pubmed publisher
Kreft K, Verbraak E, Wierenga Wolf A, Van Meurs M, Oostra B, Laman J, et al. Decreased systemic IL-7 and soluble IL-7R? in multiple sclerosis patients. Genes Immun. 2012;13:587-92 pubmed publisher
Faller E, Sugden S, McVey M, Kakal J, MacPherson P. Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation. J Immunol. 2010;185:2854-66 pubmed publisher
Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

306-IR

SKU :

306-IR-050

product name :

Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF

Description :

The Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

IL-7R alpha/CD127

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

80-90 kDa, reducing conditions

theoretical molecular weight :

54.5 kDa (monomer)

gene symbol :

IL7R

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human IL-7 R alpha/CD127 Fc Chimera (0.25 µg/mL, 100 µL/well) is immobilized on a goat anti-human IgG Fc antibody (Catalog # G-102-C ) coated plate, the concentration of recombinant human IL-7 that produces 50% of the optimal binding response is found to be 7.5-60 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

BAG62793.1

applications :

Binding Activity

source :

NS0-derived Recombinant Human IL-7R alpha/CD127 Fc Chimera Protein

USD :

434 USD

alt names :

CD127, CD127 antigen, CD127ILRA, CDW127, IL-7 R alpha, IL-7 receptor subunit alpha, IL7R, IL7R alpha, IL-7R subunit alpha, IL7RA, IL-7RA, IL-7R-alpha, interleukin 7 receptor, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, interleukin-7 receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage