Recombinant Human Integrin alpha V beta 3 Protein, CF | R&D Systems 3050-AV product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha V beta 3 Protein, CF

catalog :

3050-AV

quantity :

50 ug

price :

369 USD

citations: 12

Reference
Szlachcic A, Sochacka M, Czyrek A, Opaliński L, Krowarsch D, Otlewski J, et al. Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity. Cells. 2019;8: pubmed publisher
Bhatnagar S, Khera E, Liao J, Eniola V, Hu Y, Smith D, et al. Oral and Subcutaneous Administration of a Near-Infrared Fluorescent Molecular Imaging Agent Detects Inflammation in a Mouse Model of Rheumatoid Arthritis. Sci Rep. 2019;9:4661 pubmed publisher
Koh K, Cao Y, Mangos S, Tardi N, Dande R, Lee H, et al. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. J Clin Invest. 2019;129:1713-1726 pubmed publisher
Székács I, Farkas E, Gemes B, Takács E, Székács A, Horvath R. Integrin targeting of glyphosate and its cell adhesion modulation effects on osteoblastic MC3T3-E1 cells revealed by label-free optical biosensing. Sci Rep. 2018;8:17401 pubmed publisher
Zur Y, Rosenfeld L, Keshelman C, Dalal N, Guterman Ram G, Orenbuch A, et al. A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy. PLoS Biol. 2018;16:e2002979 pubmed publisher
Hedhli J, Czerwinski A, Schuelke M, Płoska A, Sowiński P, Hood L, et al. Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α V β 3 Integrin Activity. Sci Rep. 2017;7:3185 pubmed publisher
Brown A, Dysart M, Clarke K, STABENFELDT S, Barker T. Integrin Î±3Î²1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat. J Biol Chem. 2015;290:25534-47 pubmed publisher
Hussain S, Rodriguez Fernandez M, Braun G, Doyle F, Ruoslahti E. Quantity and accessibility for specific targeting of receptors in tumours. Sci Rep. 2014;4:5232 pubmed publisher
Lung H, Man O, Yeung M, Ko J, Cheung A, Law E, et al. SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Oncogene. 2015;34:878-89 pubmed publisher
Kwon I, Hong S, Kim Y, Nam H, Kang S, Yang S, et al. Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. PLoS ONE. 2013;8:e81165 pubmed publisher
Shojaei F, Scott N, Kang X, Lappin P, Fitzgerald A, Karlicek S, et al. Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. J Exp Clin Cancer Res. 2012;31:26 pubmed publisher
Jullienne B, Vigant F, Muth E, Chaligne R, Bouquet C, Giraudier S, et al. Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid. Gene Ther. 2009;16:1405-15 pubmed publisher

product information

brand :

R&D Systems

master code :

3050-AV

SKU :

3050-AV-050

product name :

Recombinant Human Integrin alpha V beta 3 Protein, CF

description :

The Recombinant Human Integrin alpha V beta 3 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha V beta 3 Protein, CF has been validated for the following applications: Binding Activity.

target :

Integrin alpha V beta 3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and CaCl2.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

105-150 kDa, reducing conditions

theoretical molecular weight :

110.5 kDa ( alpha V subunit), 80.8 kDa ( beta 3 subunit)

gene symbol :

ITGAV

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Vitronectin (Catalog # 2308-VN ) at 1 µg/mL can bind Recombinant Human Integrin alpha V beta 3 with an apparent KD 10 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

3050-AV

accessionNumbers :

NP_002201 (Integrin alpha V) AAA52589 (Integrin beta 3)

applications :

Binding Activity

source :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha V beta 3 protein Human Integrin alpha V subunit (Phe31-Val992) Accession # NP_002201 His-Pro GGGSGGGS Acidic Tail Human Integrin beta 3 subunit (Gly27-Asp718) Accession # AAA52589 His-Pro GGGSGGGS Basic Tail N-terminus C-terminus

2020 USD :

369

2021 USD :

369 USD

alt names :

antigen identified by monoclonal L230, CD51, CD51 antigen, integrin alpha-V, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), MSK8, Vitronectin receptor subunit alpha, VNRADKFZp686A08142

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.