Recombinant Human IGF-I R/IGF1R (His-tagged) Protein, CF | R&D Systems 305-GR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGF-I R/IGF1R (His-tagged) Protein, CF

catalog :

305-GR-050

quantity :

50 ug

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Xu L, Kohli N, Rennard R, Jiao Y, Razlog M, Zhang K, et al. Rapid optimization and prototyping for therapeutic antibody-like molecules. MAbs. 2013;5:237-54 pubmed publisher
Iozzo R, Buraschi S, Genua M, Xu S, Solomides C, Peiper S, et al. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem. 2011;286:34712-21 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

305-GR

SKU :

305-GR-050

product name :

Recombinant Human IGF-I R/IGF1R (His-tagged) Protein, CF

Description :

The Recombinant Human IGF-I R/IGF1R (His-tagged) Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGF-I R/IGF1R (His-tagged) Protein, CF has been validated for the following applications: Binding Activity.

target :

IGF-I R/IGF1R

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in NaH2PO4, NaCl, EDTA and Tween®-20 with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

150 kDa, 120 kDa and 48 kDa, reducing conditions

theoretical molecular weight :

104 kDa (single chain), 81 kDa ( alpha subunit) and 23 kDa ( beta subunit)

gene symbol :

IGF1R

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human IGF-I R/IGF1R is present at 0.5 µg/mL, the concentration of Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1 ) that produces 50% of the optimal binding response is found to be approximately 2-10 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P08069

applications :

Binding Activity

source :

NS0-derived Recombinant Human IGF-I R/IGF1R (His-tagged) Protein

USD :

470 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage