Recombinant Human COCO Protein | R&D Systems 3047-CC-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human COCO Protein

catalog :

3047-CC-050

quantity :

50 ug

price :

524 USD

citations: 4

Reference
Sajovic J, Meglič A, Corradi Z, Khan M, Maver A, Vidmar M, et al. ABCA4 Variant c.5714+5G>A in Trans With Null Alleles Results in Primary RPE Damage. Invest Ophthalmol Vis Sci. 2023;64:33 pubmed publisher
Tomkiewicz T, Nieuwenhuis S, Cremers F, Garanto A, Collin R. Correction of the Splicing Defect Caused by a Recurrent Variant in ABCA4 (c.769-784C>T) That Underlies Stargardt Disease. Cells. 2022;11: pubmed publisher
Popovic N, Hooker E, Barabino A, Flamier A, Provost F, Buscarlet M, et al. COCO/DAND5 inhibits developmental and pathological ocular angiogenesis. EMBO Mol Med. 2021;13:e12005 pubmed publisher
Albert S, Garanto A, Sangermano R, Khan M, Bax N, Hoyng C, et al. Identification and Rescue of Splice Defects Caused by Two Neighboring Deep-Intronic ABCA4 Mutations Underlying Stargardt Disease. Am J Hum Genet. 2018;102:517-527 pubmed publisher

product information

master code :

3047-CC

SKU :

3047-CC-050

product name :

Recombinant Human COCO Protein

unit size :

50 ug

description :

The Recombinant Human COCO Protein from R&D Systems is derived from E. coli. The Recombinant Human COCO Protein has been validated for the following applications: Bioactivity.

target :

COCO

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

18.2 kDa (monomer)

gene symbol :

DAND5

details of functionality :

Measured by its ability to inhibit BMP-4-induced activity in MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.15-0.75 ╡g/mL in the presence of 50 ng/mL of rhBMP-4.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_689867

applications :

Bioactivity

source long :

E. coli -derived human COCO protein Arg23-Ala189, with an N-terminal Met

source short :

E. coli

USD :

524 USD

alt names :

CER2CRL2, Cerberus 2, Cerberus like-2, cerberus-like 2, Cerberus-like protein 2, cerl-2, CERL2, CKTSF1B3, CKTSF1B3MGC126849, COCO, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DAN domain family, member 5, DAND5, Dante, DTE, FLJ38607, GREM3, GREM3cerberus 2, Gremlin-3, SP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.