product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human COCO Protein, CF
catalog :
3047-CC-050/CF
quantity :
50 ug
price :
499 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Tomkiewicz T, Nieuwenhuis S, Cremers F, Garanto A, Collin R. Correction of the Splicing Defect Caused by a Recurrent Variant in ABCA4 (c.769-784C>T) That Underlies Stargardt Disease. Cells. 2022;11: pubmed publisher
Popovic N, Hooker E, Barabino A, Flamier A, Provost F, Buscarlet M, et al. COCO/DAND5 inhibits developmental and pathological ocular angiogenesis. EMBO Mol Med. 2021;13:e12005 pubmed publisher
Albert S, Garanto A, Sangermano R, Khan M, Bax N, Hoyng C, et al. Identification and Rescue of Splice Defects Caused by Two Neighboring Deep-Intronic ABCA4 Mutations Underlying Stargardt Disease. Am J Hum Genet. 2018;102:517-527 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
3047-CC/CF
SKU :
3047-CC-050/CF
product name :
Recombinant Human COCO Protein, CF
Description :
The Recombinant Human COCO Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human COCO Protein, CF has been validated for the following applications: Bioactivity.
target :
COCO
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Supplied as a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
18.2 kDa (monomer)
gene symbol :
DAND5
details of functionality :
Measured by its ability to inhibit BMP-4-induced activity in MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.15-0.75 µg/mL in the presence of 50 ng/mL of rhBMP-4.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_689867
applications :
Bioactivity
source :
E. coli-derived Recombinant Human COCO Protein
USD :
499 USD
alt names :
CER2CRL2, Cerberus 2, Cerberus like-2, cerberus-like 2, Cerberus-like protein 2, cerl-2, CERL2, CKTSF1B3, CKTSF1B3MGC126849, COCO, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DAN domain family, member 5, DAND5, Dante, DTE, FLJ38607, GREM3, GREM3cerberus 2, Gremlin-3, SP1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.