product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-32 alpha Protein, CF
catalog :
3040-IL-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Garofano K, Rashid K, Smith M, Brantner C, Suwunnakorn S, Diemert D, et al. Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs. Sci Rep. 2023;13:2864 pubmed publisher
Kim H, Kim S, Oh Y, Lee S, Chae H. Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study. Biomedicines. 2022;10: pubmed publisher
Conod A, Silvano M, Ruiz i Altaba A. On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm. Cell Rep. 2022;38:110490 pubmed publisher
Zhang J, Sun X, Zhong L, Shen B. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Mol Med Rep. 2021;23: pubmed publisher
Gruber T, Kremenovic M, Sadozai H, Rombini N, Baeriswyl L, Maibach F, et al. IL-32γ potentiates tumor immunity in melanoma. JCI Insight. 2020;5: pubmed publisher
Palstra R, De Crignis E, Röling M, van Staveren T, Kan T, van Ijcken W, et al. Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1. Sci Adv. 2018;4:e1701729 pubmed publisher
Gorvel L, Korenfeld D, Tung T, Klechevsky E. Dendritic Cell-Derived IL-32?: A Novel Inhibitory Cytokine of NK Cell Function. J Immunol. 2017;199:1290-1300 pubmed publisher
Catalan V, Gomez Ambrosi J, Rodríguez A, Ramirez B, Valenti V, Moncada R, et al. Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss. Diabetes. 2016;65:3636-3648 pubmed
Taube J, Young G, McMiller T, Chen S, Salas J, Pritchard T, et al. Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Clin Cancer Res. 2015;21:3969-76 pubmed publisher
Osman A, Bhuyan F, Hashimoto M, Nasser H, Maekawa T, Suzu S. M-CSF inhibits anti-HIV-1 activity of IL-32, but they enhance M2-like phenotypes of macrophages. J Immunol. 2014;192:5083-9 pubmed publisher
Wong C, Dong J, Lam C. Molecular mechanisms regulating the synergism between IL-32? and NOD for the activation of eosinophils. J Leukoc Biol. 2014;95:631-42 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Heinhuis B, Koenders M, van de Loo F, Netea M, van den Berg W, Joosten L. Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2011;108:4962-7 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
3040-IL
SKU :
3040-IL-050
product name :
Recombinant Human IL-32 alpha Protein, CF
description :
The Recombinant Human IL-32 alpha Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-32 alpha Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-32 alpha
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS and DTT.
conjugate :
Unconjugated
purity :
>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
18.8 kDa, reducing conditions
theoretical molecular weight :
14.9 kDa
gene symbol :
IL32
details of functionality :
Measured by its ability to induce TNF-alpha secretion by RAW 264.7 mouse monocyte/macrophage cellsunder serum free conditions in the presence of muramyl dipeptide (MDP). Netea, M.G. et al . (2005) Proc. Nat. Acad. Sci. 102 :16309. The ED50 for this effect is 2-12 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAS80146
applications :
Bioactivity
product keywords :
3040-IL, rhIL-32a, hIL-32a, carrier-free, carrier free, 3O4O-IL, 3040IL, cytokinegrowthfact, IL32 alpha, IL-32 , IL-32 alfa, Interleukin 32 alpha, IL-32alpha, IL-32 alpha, TAIF, TAIFa, NK4, Interleukin-32a, Interleukin-32 a , cytokine, cytokines
source :
E. coli-derived Recombinant Human IL-32 alpha Protein, CF
USD :
423
USD 2025 :
432 USD
alt names :
IL32, IL32 alpha, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, interleukin 32, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.