Recombinant Human EphA2 Protein, CF | R&D Systems 3035-A2-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human EphA2 Protein, CF

catalog :

3035-A2-100

quantity :

100 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Fricke T, Gro xdf kopf A, Ensser A, Backovic M, Hahn A. Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms. Viruses. 2022;14: pubmed publisher
Cha J, Chan L, Wang Y, Chu Y, Wang C, Lee H, et al. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022;298:101817 pubmed publisher
Teo L, Boghdadi A, Homman Ludiye J, Mundiñano I, Kwan W, Bourne J. Replicating infant-specific reactive astrocyte functions in the injured adult brain. Prog Neurobiol. 2021;204:102108 pubmed publisher
Mukai M, Suruga N, Saeki N, Ogawa K. EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes. BMC Cell Biol. 2017;18:28 pubmed publisher
Takasugi M, Okada R, Takahashi A, Virya Chen D, Watanabe S, Hara E. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nat Commun. 2017;8:15729 pubmed publisher
Park S, Park S, Kim D, Pyo A, Kimura R, Sathirachinda A, et al. Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2. PLoS ONE. 2015;10:e0132976 pubmed publisher
Liao Chan S, Daine Matsuoka B, Heald N, Wong T, Lin T, Cai A, et al. Quantitative assessment of antibody internalization with novel monoclonal antibodies against Alexa fluorophores. PLoS ONE. 2015;10:e0124708 pubmed publisher
Hahn A, Kaufmann J, Wies E, Naschberger E, Panteleev Ivlev J, Schmidt K, et al. The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat Med. 2012;18:961-6 pubmed publisher
Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, et al. A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res. 2008;68:9367-74 pubmed publisher

product information

brand :

R&D Systems

master code :

3035-A2

SKU :

3035-A2-100

product name :

Recombinant Human EphA2 Protein, CF

description :

The Recombinant Human EphA2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human EphA2 Protein, CF has been validated for the following applications: Binding Activity.

target :

EphA2

category :

Proteins and Enzymes

sizes available :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

70-75 kDa, reducing conditions

theoretical molecular weight :

56.9 kDa

gene symbol :

EPHA2

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhEphA2 at 2 µg/mL (100 µL/well) can bind rmEphrin-A1/Fc Chimera with a linear range of 0.078-5 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P29317

applications :

Binding Activity

source :

NS0-derived Recombinant Human EphA2 Protein, CF

USD :

388

USD 2023 :

394 USD

alt names :

ARCC2, EC 2.7.10, EC 2.7.10.1, Eck, ECKepithelial cell receptor protein tyrosine kinase, EPH receptor A2, EphA2, ephrin type-A receptor 2, Epithelial cell kinase, Myk2, Sek2, soluble EPHA2 variant 1, Tyrosine-protein kinase receptor ECK

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage