Recombinant Human Norrin Protein, CF | R&D Systems 3014-NR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Norrin Protein, CF

catalog :

3014-NR

quantity :

25 ug

price :

369 USD

citations: 3

Reference
El Sehemy A, Selvadurai H, Ortín Martínez A, Pokrajac N, Mamatjan Y, Tachibana N, et al. Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt. J Clin Invest. 2020;130:3069-3086 pubmed publisher
Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, et al. Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun. 2019;10:5243 pubmed publisher
Lai M, Zhang C, Shi J, Johnson V, Khandan L, McVey J, et al. TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Cell Rep. 2017;19:2809-2822 pubmed publisher

product information

brand :

R&D Systems

master code :

3014-NR

SKU :

3014-NR-025

product name :

Recombinant Human Norrin Protein, CF

description :

The Recombinant Human Norrin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Norrin Protein, CF has been validated for the following applications: Bioactivity.

target :

Norrin/NDP

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in HCl.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

12.6 kDa

gene symbol :

NDP

details of functionality :

Measured by its ability to activate Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells expressing human Frizzled-4 and human LRP-5. The ED50 for this effect is 30-150 ng/ml.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

3014-NR

accessionNumbers :

Q00604

applications :

Bioactivity

source :

E. coli -derived human Norrin protein Lys25-Ser133, with an N-terminal Met

2020 USD :

349

2021 USD :

369 USD

alt names :

EVR2, exudative vitreoretinopathy 2 (X-linked), FEVR, ND, NDP, Norrie disease (pseudoglioma), Norrie disease protein, norrin, X-linked exudative vitreoretinopathy 2 protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.