Recombinant Human Norrin Protein, CF | R&D Systems 3014-NR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Norrin Protein, CF

catalog :

3014-NR-025

quantity :

25 ug

price :

499 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Ding J, Lee S, Vlahos L, Yuki K, Rada C, van Unen V, et al. Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice. Nat Commun. 2023;14:2947 pubmed publisher
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
El Sehemy A, Selvadurai H, Ortín Martínez A, Pokrajac N, Mamatjan Y, Tachibana N, et al. Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and Wnt. J Clin Invest. 2020;130:3069-3086 pubmed publisher
Díaz Coránguez M, Lin C, Liebner S, Antonetti D. Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability. J Biol Chem. 2020;295:4647-4660 pubmed publisher
Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, et al. Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat Commun. 2019;10:5243 pubmed publisher
le Riche A, Aberdam E, Marchand L, Frank E, Jahoda C, Petit I, et al. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin. Stem Cells. 2019;37:1166-1175 pubmed publisher
Lai M, Zhang C, Shi J, Johnson V, Khandan L, McVey J, et al. TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Cell Rep. 2017;19:2809-2822 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3014-NR

SKU :

3014-NR-025

product name :

Recombinant Human Norrin Protein, CF

Description :

The Recombinant Human Norrin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Norrin Protein, CF has been validated for the following applications: Bioactivity.

target :

Norrin

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in HCl.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

12.6 kDa

gene symbol :

NDP

details of functionality :

Measured by its ability to activate Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells expressing human Frizzled-4 and human LRP-5. The ED50 for this effect is 30-150 ng/ml.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q00604

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Norrin Protein

USD :

499 USD

alt names :

EVR2, exudative vitreoretinopathy 2 (X-linked), FEVR, ND, NDP, Norrie disease (pseudoglioma), Norrie disease protein, norrin, X-linked exudative vitreoretinopathy 2 protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage