Recombinant Human Wnt-7a Protein | R&D Systems 3008-WN product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Wnt-7a Protein

catalog :

3008-WN

quantity :

25 ug

price :

419 USD

citations: 18

Reference
Wang Y, Feige P, Brun C, Hekmatnejad B, Dumont N, Renaud J, et al. EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions. Cell Stem Cell. 2019;24:419-432.e6 pubmed publisher
Weng C, Ding P, Liu Y, Hawse J, Subramaniam M, Wu C, et al. Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. Oncogene. 2019;38:2005-2019 pubmed publisher
Lee S, Shin S, Zhong P, Kim H, Kim D, Kim J, et al. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018;9:3434 pubmed publisher
Cheng X, Huang H, Luo X, Shi B, Li J. Wnt7a induces satellite cell expansion, myofiber hyperplasia and hypertrophy in rat craniofacial muscle. Sci Rep. 2018;8:10613 pubmed publisher
Condello S, Sima L, Ivan C, Cárdenas H, Schiltz G, Mishra R, et al. Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche. Cancer Res. 2018;78:2990-3001 pubmed publisher
Cheng X, Song L, Lan M, Shi B, Li J. Morphological and molecular comparisons between tibialis anterior muscle and levator veli palatini muscle: A preliminary study on their augmentation potential. Exp Ther Med. 2018;15:247-253 pubmed publisher
Jang J, Jung Y, Chae S, Chung S, Kim S, Yoon Y. WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells. Biochem Biophys Res Commun. 2017;484:442-449 pubmed publisher
Jang J, Jung Y, Kim Y, Jho E, Yoon Y. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974. Sci Rep. 2017;7:41612 pubmed publisher
Farah O, Biechele S, Rossant J, Dufort D. Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs. Dev Biol. 2017;422:58-69 pubmed publisher
Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, et al. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE. 2014;9:e104937 pubmed publisher
Kilander M, Dahlström J, Schulte G. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal. 2014;26:1943-9 pubmed publisher
Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, et al. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014;205:97-111 pubmed publisher
Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, et al. Noncanonical Wnt5a enhances Wnt/?-catenin signaling during osteoblastogenesis. Sci Rep. 2014;4:4493 pubmed publisher
Thrasivoulou C, Millar M, Ahmed A. Activation of intracellular calcium by multiple Wnt ligands and translocation of ?-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/?-catenin pathways. J Biol Chem. 2013;288:35651-9 pubmed publisher
von Maltzahn J, Renaud J, Parise G, Rudnicki M. Wnt7a treatment ameliorates muscular dystrophy. Proc Natl Acad Sci U S A. 2012;109:20614-9 pubmed publisher
Tran T, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012;287:32651-64 pubmed
Gogolla N, Galimberti I, Deguchi Y, Caroni P. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron. 2009;62:510-25 pubmed publisher
Ma L, Webb S, Chan C, Zhang J, Miller A. Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Dev Biol. 2009;327:143-57 pubmed publisher

product information

SKU :

3008-WN-025

product name :

Recombinant Human Wnt-7a Protein

unit size :

25 ug

Description :

The Recombinant Human Wnt-7a Protein from R D Systems is derived from CHO. The Recombinant Human Wnt-7a Protein has been validated for the following applications: Bioactivity.

target :

Wnt-7a

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

70%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

40-65 kDa, reducing conditions

theoretical molecular weight :

35.5 kDa

gene symbol :

WNT7A

details of functionality :

Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 1-3 µg/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a. STRONG Optimal dilutions should be determined by each laboratory for each application. /STRONG

endotoxin note :

0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

3008-WN

accessionNumbers :

O00755

applications :

Bioactivity

source :

CHO-derived Recombinant Human Wnt-7a Protein

2020 Proposedprice USD :

419 USD

alt names :

protein Wnt-7a, proto-oncogene Wnt7a protein, wingless-type MMTV integration site family, member 7A, Wnt7a

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.