This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Latent TGF-beta 1 Protein
catalog :
299-LT-005
quantity :
5 ug (also 25 ug)
price :
408 USD
citations: 19
Reference
Fukaya T, Uto T, Mitoma S, Takagi H, Nishikawa Y, Tominaga M, et al. Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells. Cell Rep. 2023;42:112431 pubmed publisher
Pitmon E, Meehan E, Ahmadi E, Adler A, Wang K. High glucose promotes regulatory T cell differentiation. PLoS ONE. 2023;18:e0280916 pubmed publisher
Torres L, Chweih H, Fabris F, Gotardo E, Leonardo F, Saad S, et al. TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice. Cells. 2022;11: pubmed publisher
Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al. Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed publisher
Briggs D, Langford Smith A, Birchenough H, Jowitt T, Kielty C, Enghild J, et al. Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation. J Biol Chem. 2020;295:5278-5291 pubmed publisher
Broekelmann T, Bodmer N, Mecham R. Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1. J Biol Chem. 2020;295:2687-2697 pubmed publisher
Guo L, Hou Y, Song L, Zhu S, Lin F, Bai Y. D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion. Stem Cells Int. 2018;2018:7168231 pubmed publisher
Pan F, Xiang H, Yan J, Hong L, Zhang L, Liu Y, et al. Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin ?v/TGF-? Axis. Scand J Immunol. 2017;85:441-449 pubmed publisher
Jones K, Ballesteros A, Mentink Kane M, Warren J, Rattila S, Malech H, et al. PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-?1 Pathway. PLoS ONE. 2016;11:e0158050 pubmed publisher
Zhang J, Wong M, Wong M, Gross S, Chen J, Pollock C, et al. A cationic-independent mannose 6-phosphate receptor inhibitor (PXS64) ameliorates kidney fibrosis by inhibiting activation of transforming growth factor-β1. PLoS ONE. 2015;10:e0116888 pubmed publisher
Ballesteros A, Mentink Kane M, Warren J, Kaplan G, Dveksler G. Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). J Biol Chem. 2015;290:4422-31 pubmed publisher
Tulley S, Chen W. Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-? signaling. J Biol Chem. 2014;289:15280-96 pubmed publisher
Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, et al. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression. Nat Immunol. 2013;14:1256-65 pubmed publisher
Gonzalez Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, et al. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013;113:1331-44 pubmed publisher
Ma W, Han W, Greer P, Tuder R, Toque H, Wang K, et al. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest. 2011;121:4548-66 pubmed publisher
Walsh L, Damjanovski S. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-?1 resulting in epithelial to mesenchymal transition. Cell Commun Signal. 2011;9:10 pubmed publisher
Stockis J, Colau D, Coulie P, Lucas S. Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur J Immunol. 2009;39:3315-22 pubmed publisher
Van Aarsen L, Leone D, Ho S, Dolinski B, McCoon P, Lepage D, et al. Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res. 2008;68:561-70 pubmed publisher
Torrealba J, Katayama M, Fechner J, Jankowska Gan E, Kusaka S, Xu Q, et al. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J Immunol. 2004;172:5753-64 pubmed
product information
brand :
R&D Systems
master code :
299-LT
SKU :
299-LT-005
product name :
Recombinant Human Latent TGF-beta 1 Protein
unit size :
5 ug (also 25 ug)
seo description :
The Recombinant Human Latent TGF-beta 1 Protein from R&D Systems is derived from CHO. The Recombinant Human Latent TGF-beta 1 Protein has been validated for the following applications: Bioactivity.
target :
TGF-beta 1
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in PBS and Glycerol with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
36-42 kDa 11 kDa, reducing conditions 80-95 kDa 24 kDa, non-reducing conditions
theoretical molecular weight :
28.5 kDa (LAP) 12.8 kDa (Mature), Monomer
gene symbol :
TGFB1
details of functionality :
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang,áM. etáal . (1995) Cytokine 7 :389. The ED50 for this effect is 10-70 ng/mL before acid activation and 0.15-0.9 ng/mL after acid activation.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Latent TGF-beta 1 Protein Bioactivity
accessionNumbers :
P01137
applications :
Bioactivity
source :
CHO-derived Recombinant Human Latent TGF-beta 1 Protein
extended description :
Soon to be discontinued. New Cat# will be 299-LTB
USD :
408 USD
product details :
Soon to be discontinued. New Cat# will be 299-LTB
alt names :
CEDLAP, DPD1, latency-associated peptide, TGF beta, TGF beta1, TGFB, TGFB1, TGFbeta, TGFbeta 1, TGF-beta 1 protein, TGF-beta-1, transforming growth factor beta-1, transforming growth factor, beta 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening. 3 months, <= -20 ░C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.