product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TACE/ADAM17 Protein, CF
catalog :
2978-AD-010
quantity :
10 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Scherschinski L, Prem M, Kremenetskaia I, Tinhofer I, Vajkoczy P, Karbe A, et al. Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma. Int J Mol Sci. 2022;23: pubmed publisher
Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, et al. A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma. Sci Rep. 2016;6:32259 pubmed publisher
Marczynska J, Ozga A, Wlodarczyk A, Majchrzak Gorecka M, Kulig P, Banas M, et al. The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. J Immunol. 2014;193:2753-63 pubmed publisher
Ramdas V, McBride M, Denby L, Baker A. Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Am J Pathol. 2013;183:1885-1896 pubmed publisher
Wang Y, Huang Z, Nayak P, Matthews B, Warburton D, Shi W, et al. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. J Biol Chem. 2013;288:25646-57 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2978-AD
SKU :
2978-AD-010
product name :
Recombinant Mouse TACE/ADAM17 Protein, CF
Description :
The Recombinant Mouse TACE/ADAM17 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TACE/ADAM17 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
TACE/ADAM17
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MES and NaCl.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
76 kDa, 63 kDa, 21 kDa and 18 kDa, reducing conditions
theoretical molecular weight :
63 kDa, 40 kDa, 23 kDa, 18 kDa
gene symbol :
Adam17
details of functionality :
Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003 ). The specific activity is 500 pmol/min/µg, as measured under the described conditions. Note: It is extremely important that the assay solution does not contain salt as it inhibits TACE activity.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAC62934
applications :
Enzyme Activity
source :
NS0-derived Recombinant Mouse TACE/ADAM17 Protein
USD :
423 USD
alt names :
ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, ADAM17, ADAM18, CD156b, CD156b antigen, CSVP, disintegrin and metalloproteinase domain-containing protein 17, EC 3.4.24.86, MGC71942, Snake venom-like protease, TACEcSVP, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.