Recombinant Mouse BACE-2 Protein, CF | R&D Systems 2977-AS-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse BACE-2 Protein, CF

catalog :

2977-AS-020

quantity :

20 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Abdul Hay S, Sahara T, McBride M, Kang D, Leissring M. Identification of BACE2 as an avid ß-amyloid-degrading protease. Mol Neurodegener. 2012;7:46 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher

product information

master code :

2977-AS

SKU :

2977-AS-020

product name :

Recombinant Mouse BACE-2 Protein, CF

unit size :

20 ug

description :

The Recombinant Mouse BACE-2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse BACE-2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

BACE-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

55-76 kDa, reducing conditions

theoretical molecular weight :

48 kDa

gene symbol :

Bace2

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010 ). The specific activity is 50 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9JL18

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived mouse BACE-2 protein Phe29-Pro462 (Tyr357His) with a C-terminal 6-His tag

source short :

NS0

USD :

456 USD

alt names :

AEPLC, Asp 1, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, BACE2, beta secretase 2, beta-secretase 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease, CEAP1, Down region aspartic protease, Down syndrome region aspartic protease, DRAPBAE2, EC 3.4.23, EC 3.4.23.45, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, transmembrane aspartic proteinase Asp1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage