Recombinant Mouse BACE-1 Protein, CF | R&D Systems 2976-AS-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse BACE-1 Protein, CF

catalog :

2976-AS-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
M xfc ller S, Shmueli M, Feng X, T xfc shaus J, Schumacher N, Clark R, et al. The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023;18:13 pubmed publisher
Huttunen H, GUENETTE S, Peach C, Greco C, Xia W, Kim D, et al. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007;282:28285-95 pubmed
Hutter Paier B, Huttunen H, Puglielli L, Eckman C, Kim D, Hofmeister A, et al. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004;44:227-38 pubmed

product information

master code :

2976-AS

SKU :

2976-AS-050

product name :

Recombinant Mouse BACE-1 Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse BACE-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse BACE-1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

BACE-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

68 kDa, reducing conditions

theoretical molecular weight :

50 kDa

gene symbol :

Bace1

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2 (Catalog # ES004 ). The specific activity is 2 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P56818

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived mouse BACE-1 protein Thr22-Thr457, with a C-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

APP beta-secretase, ASP2, Aspartyl protease 2, BACE1, BACEAsp 2, beta-secretase 1, beta-secretase 1 precursor variant 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site APP-cleaving enzyme 1, EC 3.4.23, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage