product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TFPI Protein, CF
catalog :
2974-PI-010
quantity :
10 ug
price :
434 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Bhargavan B, Kanmogne G. SARS-CoV-2 Spike Proteins and Cell-Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for the Pathogenesis of COVID-19 Coagulop. Int J Mol Sci. 2023;24: pubmed publisher
Bhargavan B, Kanmogne G. SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Hsieh L, Dos Santos S, Hall B, Ogbechi J, Loglo A, Salguero F, et al. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions. PLoS Pathog. 2022;18:e1010280 pubmed publisher
Che S, DeLeonardis C, Shuler M, Stokol T. Tissue factor-expressing tumor cells can bind to immobilized recombinant tissue factor pathway inhibitor under static and shear conditions in vitro. PLoS ONE. 2015;10:e0123717 pubmed publisher
Nicol G, Han M, Kim J, Birse C, Brand E, Nguyen A, et al. Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol Cell Proteomics. 2008;7:1974-82 pubmed publisher
image
image 1 :
R&D Systems 2974-PI-010 image 1
Recombinant Human TFPI Protein Enzyme Activity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2974-PI
SKU :
2974-PI-010
product name :
Recombinant Human TFPI Protein, CF
Description :
The Recombinant Human TFPI Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TFPI Protein, CF has been validated for the following applications: Inhibition Activity.
target :
TFPI
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in NaH2PO4 and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
41 kDa, reducing conditions
theoretical molecular weight :
31 kDa
gene symbol :
TFPI
details of functionality :
Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The IC50 value is 0.75 nM, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P10646
applications :
Inhibition Activity
source :
NS0-derived Recombinant Human TFPI Protein
USD :
434 USD
alt names :
convertin, EPI, EPITFPI1LACITFI, Extrinsic pathway inhibitor, LACI, Lipoprotein-associated coagulation inhibitor, tissue factor pathway inhibitor, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.