Recombinant Mouse LRP-6 His Tagged Protein, CF | R&D Systems 2960-LR-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse LRP-6 His Tagged Protein, CF

catalog :

2960-LR-025

quantity :

25 ug

price :

468 USD

citations: 4

Reference
Shay T, Jang S, Brittain T, Chen X, Walker B, Tebbutt C, et al. Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder. Nat Commun. 2024;15:7853 pubmed publisher
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
Liu S, Leask A. CCN2 modulates hair follicle cycling in mice. Mol Biol Cell. 2013;24:3939-44 pubmed publisher
Krause C, Korchynskyi O, de Rooij K, Weidauer S, de Gorter D, van Bezooijen R, et al. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem. 2010;285:41614-26 pubmed publisher

product information

master code :

2960-LR

SKU :

2960-LR-025

product name :

Recombinant Mouse LRP-6 His Tagged Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse LRP-6 His Tagged Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse LRP-6 His Tagged Protein, CF has been validated for the following applications: Binding Activity.

target :

LRP-6

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

170 kDa, reducing conditions

theoretical molecular weight :

152.6 kDa

gene symbol :

Lrp6

details of functionality :

Measured by its binding ability in a functional ELISA. rmLRP-6 binds rhDkk-1, biotin with an apparent KD 15 nM. Biotinylated rmWnt-3a immobilized on a streptavidin-coated plate at 1 ╡g/mL can bind rmLRP-6 with a linear range of 0.2-10 ╡g/mL.

endotoxin note :

<0.1 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O88572

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse LRP-6 protein Ala20-Pro1368, with a C-terminal 6-His tag

source short :

NS0

USD :

468 USD

alt names :

ADCAD2, FLJ90062, FLJ90421, low density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6, LRP6, LRP-6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.