Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF | R&D Systems 296-HR-050/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF

catalog :

296-HR-050/CF

quantity :

50 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Shu M, Yan H, Xu C, Wu Y, Chi Z, Nian W, et al. A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo. Sci Rep. 2020;10:2986 pubmed publisher
Morano M, Ronchi G, NicolÃ² V, Fornasari B, Crosio A, Perroteau I, et al. Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation. Sci Rep. 2018;8:5047 pubmed publisher
Fornasari B, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Mol Cell Neurosci. 2016;77:87-94 pubmed publisher
Solomon W, Wilson N, ANDERSON L, Pitts S, Patrickson J, Liu M, et al. Neuregulin-1 attenuates mortality associated with experimental cerebral malaria. J Neuroinflammation. 2014;11:9 pubmed publisher
Macleod S, Elgadi M, Bossi G, Sankar U, Pisio A, Agopsowicz K, et al. HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice. Cancer Gene Ther. 2012;19:888-98 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
Wehrman T, Raab W, Casipit C, Doyonnas R, Pomerantz J, Blau H. A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions. Proc Natl Acad Sci U S A. 2006;103:19063-8 pubmed
Hamra F, Chapman K, Nguyen D, Garbers D. Identification of neuregulin as a factor required for formation of aligned spermatogonia. J Biol Chem. 2007;282:721-30 pubmed
Chakravarti P, Henry M, Quelle F. Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells. Int J Oncol. 2005;26:509-14 pubmed
Xu Z, Jiang J, Ford G, Ford B. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochem Biophys Res Commun. 2004;322:440-6 pubmed

product information

brand :

R&D Systems

master code :

296-HR/CF

SKU :

296-HR-050/CF

product name :

Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF

description :

The Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF from R&D Systems is derived from E. coli. The Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF has been validated for the following applications: Bioactivity.

target :

Neuregulin-1 alpha/NRG1 alpha

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

8 kDa, reducing conditions

theoretical molecular weight :

7 kDa

gene symbol :

NRG1

details of functionality :

Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 10-50 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q7RTV8

applications :

Bioactivity

source :

E. coli-derived Recombinant Human NRG1-alpha/HRG1-alpha EGF Domain, CF

USD :

377

USD 2023 :

377 USD

alt names :

ARIA, GGF2, Heregulin-1, HGL, HRG, HRG1, HRG1-alpha, HRG1-beta 1, MST131, MSTP131, neuregulin 1, Neuregulin1, Neuregulin1 alpha, NRG1, pro-neuregulin-1, membrane-bound isoform, pro-NRG1, sensory and motor neuron derived factor, SMDF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage