This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Oncostatin M (OSM) Protein
catalog :
295-OM
quantity :
10 ug (also 50 ug, 1 mg)
price :
209 USD
citations: 61
Reference
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van Keulen D, Pouwer M, Pasterkamp G, van Gool A, Sollewijn Gelpke M, Princen H, et al. Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice. PLoS ONE. 2018;13:e0204911 pubmed publisher
Skrzypczyk A, Kehr S, Krystel I, Bernhart S, Giri S, Bader A, et al. Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes. Stem Cells Int. 2018;2018:5692840 pubmed publisher
Ayabe H, Anada T, Kamoya T, Sato T, Kimura M, Yoshizawa E, et al. Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling. Stem Cell Reports. 2018;11:306-316 pubmed publisher
Fisher K, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo M, Thomas S, et al. A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. J Cell Sci. 2018;131: pubmed publisher
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Fagg W, Liu N, Yang M, Cheng K, Chung E, Kim J, et al. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplant. 2017;26:1868-1877 pubmed publisher
Han Y, Kang Y, Shivakumar S, Bharti D, Son Y, Choi Y, et al. Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro. Int J Med Sci. 2017;14:1418-1429 pubmed publisher
Oike T, Sato Y, Kobayashi T, Miyamoto K, Nakamura S, Kaneko Y, et al. Stat3 as a potential therapeutic target for rheumatoid arthritis. Sci Rep. 2017;7:10965 pubmed publisher
Camp J, Sekine K, Gerber T, Loeffler Wirth H, Binder H, Gac M, et al. Multilineage communication regulates human liver bud development from pluripotency. Nature. 2017;546:533-538 pubmed publisher
Li Q, Hutchins A, Chen Y, Li S, Shan Y, Liao B, et al. A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes. Nat Commun. 2017;8:15166 pubmed publisher
Pashos E, Park Y, Wang X, Raghavan A, Yang W, Abbey D, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20:558-570.e10 pubmed publisher
Chandrika G, Natesh K, Ranade D, Chugh A, Shastry P. Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells. Tumour Biol. 2017;39:1010428317695921 pubmed publisher
Narmada B, Goh Y, Li H, Sinha S, Yu H, Cheung C. Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals. Stem Cells Transl Med. 2017;6:851-863 pubmed publisher
Choudhury Y, Toh Y, Xing J, Qu Y, Poh J, Li H, et al. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Sci Rep. 2017;7:41238 pubmed publisher
Yang L, Wang R, Ma Z, Xiao Y, Nan Y, Wang Y, et al. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation. J Virol. 2017;91: pubmed publisher
Maumus M, Roussignol G, Toupet K, Penarier G, Bentz I, Teixeira S, et al. Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFNγ-Primed Equine Mesenchymal Stem Cells. Front Immunol. 2016;7:392 pubmed
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
Walker E, Johnson R, Hu Y, Brennan H, Poulton I, Zhang J, et al. Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem. 2016;291:21703-21716 pubmed
Harwardt T, Lukas S, Zenger M, Reitberger T, Danzer D, Übner T, et al. Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog. 2016;12:e1005748 pubmed publisher
Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, et al. Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016;6:29358 pubmed publisher
Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, et al. Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS ONE. 2015;10:e0134995 pubmed publisher
Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, et al. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res. 2015;16:14 pubmed publisher
Nagiec M, Skepner A, Negri J, Eichhorn M, Kuperwasser N, Comer E, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS ONE. 2015;10:e0120295 pubmed publisher
Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, et al. RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol. 2015;194:2862-70 pubmed publisher
Czysz K, Minger S, Thomas N. DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE. 2015;10:e0117689 pubmed publisher
Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska Mrowiecka M, et al. The expression and regulation of chemerin in the epidermis. PLoS ONE. 2015;10:e0117830 pubmed publisher
Ehlting C, Böhmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, et al. Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2. Cell Signal. 2015;27:555-67 pubmed publisher
Gao W, Zhou P, Ma X, Tschudy Seney B, Chen J, Magner N, et al. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS ONE. 2014;9:e112698 pubmed publisher
Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, et al. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 2014;74:6806-19 pubmed publisher
Pini L, Tiberio L, Venkatesan N, Bezzi M, Corda L, Luisetti M, et al. The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency. Respir Res. 2014;15:112 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, et al. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine. 2014;68:101-9 pubmed publisher
Takebe T, Zhang R, Koike H, Kimura M, Yoshizawa E, Enomura M, et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc. 2014;9:396-409 pubmed publisher
Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, et al. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports. 2013;1:322-35 pubmed publisher
Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, et al. CCAAT/enhancer binding protein-mediated regulation of TGF? receptor 2 expression determines the hepatoblast fate decision. Development. 2014;141:91-100 pubmed publisher
van t Wout E, Dickens J, van Schadewijk A, Haq I, Kwok H, Ordonez A, et al. Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin. Hum Mol Genet. 2014;23:929-41 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
Larsen J, Hansen M, Møller B, Madsen P, Scheller J, Nielsen M, et al. Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol Cell Biol. 2010;30:4175-87 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Rahmoun M, Moles J, Pedretti N, Mathieu M, Fremaux I, Raison Peyron N, et al. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J Invest Dermatol. 2009;129:671-81 pubmed publisher
Kato A, Peters A, Suh L, Carter R, Harris K, Chandra R, et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2008;121:1385-92, 1392.e1-2 pubmed publisher
Brechter A, Lerner U. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007;56:910-23 pubmed
Sugaya M, Fang L, Cardones A, Kakinuma T, Jaber S, Blauvelt A, et al. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J Immunol. 2006;177:7665-72 pubmed
Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole A, et al. Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum. 2006;54:3152-62 pubmed
Baharvand H, Hashemi S, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006;50:645-52 pubmed
He W, Gong K, Smith D, Ip N. The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett. 2005;579:4317-23 pubmed
Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
Scaffidi A, Mutsaers S, Moodley Y, McAnulty R, Laurent G, Thompson P, et al. Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. Br J Pharmacol. 2002;136:793-801 pubmed
Savarese T, Campbell C, McQuain C, Mitchell K, Guardiani R, Quesenberry P, et al. Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Cytokine. 2002;17:324-34 pubmed
product information
brand :
R&D Systems
master code :
295-OM
SKU :
295-OM-010
product name :
Recombinant Human Oncostatin M (OSM) Protein
description :
The Recombinant Human Oncostatin M (OSM) Protein from R&D Systems is derived from E. coli. The Recombinant Human Oncostatin M (OSM) Protein has been validated for the following applications: Bioactivity.
target :
Oncostatin M/OSM
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug, 1 mg)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
theoretical molecular weight :
22 kDa
gene symbol :
OSM
details of functionality :
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.05-0.3 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
295-OM
accessionNumbers :
P13725
applications :
Bioactivity
source :
E. coli -derived human Oncostatin M/OSM protein Ala26-Arg221
extended description :
A New and Improved rh OSM is Now Available! It is HEK293 expressed and competitively priced!
2020 USD :
209
2021 USD :
209 USD
product details :
A New and Improved rh OSM is Now Available! It is HEK293 expressed and competitively priced!
alt names :
MGC20461, oncostatin M, oncostatin-M
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.