Recombinant Human Clusterin Protein, CF | R&D Systems 2937-HS-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Clusterin Protein, CF

catalog :

2937-HS-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino F, Bindu D, et al. Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function. bioRxiv. 2023;: pubmed publisher
Chintala S, Pan J, Satapathy S, Condruti R, Hao Z, Liu P, et al. Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy. Int J Mol Sci. 2023;24: pubmed publisher
Ungsudechachai T, Honsawek S, Jittikoon J, Udomsinprasert W. Clusterin exacerbates interleukin-1β-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis. Sci Rep. 2022;12:9963 pubmed publisher
Vargas A, Kim H, Baral E, Yu W, CRAFT C, Lee E. Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa. PLoS ONE. 2017;12:e0182389 pubmed publisher
Schnepp P, Lee D, Guldner I, O Tighearnaigh T, Howe E, Palakurthi B, et al. GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment. Cancer Res. 2017;77:2844-2856 pubmed publisher
Aoyama M, Hata K, Higashisaka K, Nagano K, Yoshioka Y, Tsutsumi Y. Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes. Biochem Biophys Res Commun. 2016;480:690-695 pubmed publisher
Bauskar A, Mack W, Mauris J, ArgÃ¼eso P, Heur M, Nagel B, et al. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS ONE. 2015;10:e0138958 pubmed publisher
Doudevski I, Rostagno A, Cowman M, Liebmann J, Ritch R, Ghiso J. Clusterin and complement activation in exfoliation glaucoma. Invest Ophthalmol Vis Sci. 2014;55:2491-9 pubmed publisher
An E, Sen S, Park S, Gordish Dressman H, Hathout Y. Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. Invest Ophthalmol Vis Sci. 2010;51:3379-86 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

2937-HS

SKU :

2937-HS-050

product name :

Recombinant Human Clusterin Protein, CF

description :

The Recombinant Human Clusterin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Clusterin Protein, CF has been validated for the following applications: Bioactivity.

target :

Clusterin

unit size :

50 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

40 kDa and 39 kDa, under reducing conditions

theoretical molecular weight :

26.7 kDa ( alpha chain) and 24.2 kDa (ß chain)

gene symbol :

CLU

details of functionality :

Measured by its ability to induce clustering of Caki-2 human clear cell carcinoma epithelial cells. Schwochau, G. et al . (1998) Kidney Int. 53 :1647.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_001822

applications :

Bioactivity

product keywords :

2937-HS, rhClusterin, hClusterin, carrier-free, carrier free, 2937HS, alpha-clustrin, beta-clustrin, sulfated glycoprotein 2, Clusterin-alpha, Clusterin alpha, Apolipoprotein J

source :

NS0-derived Recombinant Human Clusterin Protein, CF

USD :

423

USD 2025 :

432 USD

alt names :

40, 40, sulfated glycoprotein 2, Aging-associated gene 4 protein, aging-associated protein 4, apo-J, APOJ, Apolipoprotein J, CLI, CLIclusterin (complement lysis inhibitor, SP-40, CLU, clusterin, Complement cytolysis inhibitor, complement lysis inhibitor, Complement-associated protein SP-40, Ku70-binding protein 1, KUB1SGP2, MGC24903, NA1/NA2, SGP-2, SP-40, sulfated glycoprotein 2, Testosterone-repressed prostate message 2, testosterone-repressed prostate message 2, apolipoprotein J), TRPM-2, TRPM-2TRPM2

more info or order :

R&D Systems product webpage