Recombinant Human BMP-10 Protein | R&D Systems 2926-BP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BMP-10 Protein

catalog :

2926-BP

quantity :

25 ug

price :

489 USD

citations: 12

Reference
Subileau M, Merdzhanova G, Ciais D, Collin Faure V, Feige J, Bailly S, et al. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation. Stem Cell Reports. 2019;12:98-111 pubmed publisher
Tillet E, Ouarné M, Desroches Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963-10974 pubmed publisher
Mitrofan C, Appleby S, Nash G, Mallat Z, Chilvers E, Upton P, et al. Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J Biol Chem. 2017;292:13714-13726 pubmed publisher
Tachida Y, Izumi N, Sakurai T, Kobayashi H. Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells. Biol Open. 2017;6:370-380 pubmed publisher
Jiang H, Salmon R, Upton P, Wei Z, Lawera A, Davenport A, et al. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. J Biol Chem. 2016;291:2954-66 pubmed publisher
Levet S, OuarnÃ© M, Ciais D, Coutton C, Subileau M, Mallet C, et al. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A. 2015;112:E3207-15 pubmed publisher
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers T, et al. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012;119:6162-71 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher

product information

brand :

R&D Systems

master code :

2926-BP

SKU :

2926-BP-025

product name :

Recombinant Human BMP-10 Protein

description :

The Recombinant Human BMP-10 Protein from R&D Systems is derived from CHO. The Recombinant Human BMP-10 Protein has been validated for the following applications: Bioactivity.

target :

BMP-10

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

13 kDa, reducing conditions

theoretical molecular weight :

12.2 kDa (monomer)

gene symbol :

BMP10

details of functionality :

Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 15-60 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

2926-BP

accessionNumbers :

O95393

applications :

Bioactivity

source :

Chinese Hamster Ovary cell line, CHO-derived human BMP-10 protein Asn317-Arg424

2020 USD :

489

2021 USD :

489 USD

alt names :

BMP10, BMP-10, bone morphogenetic protein 10, MGC126783

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.