product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-10 Protein
catalog :
2926-BP-025
quantity :
25 ug
price :
573 USD
more info or order :
R&D Systems product webpage
citations: 16
Reference
Cheng Y, Anzell A, Morosky S, Schwartze T, Hinck C, Hinck A, et al. Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells. Cells. 2024;13: pubmed publisher
Ivaldo C, Passalacqua M, Furfaro A, d Abramo C, Ruiz S, Chatterjee P, et al. Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10. Sci Rep. 2023;13:597 pubmed publisher
Shonibare Z, Monavarian M, O CONNELL K, Altomare D, Shelton A, Mehta S, et al. Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. Cell Rep. 2022;40:111066 pubmed publisher
Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, et al. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 2022;13:2395 pubmed publisher
Kumar R, Grinberg A, Li H, Kuo T, Sako D, Krishnan L, et al. Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily. Sci Rep. 2021;11:18341 pubmed publisher
Subileau M, Merdzhanova G, Ciais D, Collin Faure V, Feige J, Bailly S, et al. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation. Stem Cell Reports. 2019;12:98-111 pubmed publisher
Tillet E, Ouarné M, Desroches Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963-10974 pubmed publisher
Mitrofan C, Appleby S, Nash G, Mallat Z, Chilvers E, Upton P, et al. Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J Biol Chem. 2017;292:13714-13726 pubmed publisher
Tachida Y, Izumi N, Sakurai T, Kobayashi H. Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells. Biol Open. 2017;6:370-380 pubmed publisher
Levet S, Ouarné M, Ciais D, Coutton C, Subileau M, Mallet C, et al. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A. 2015;112:E3207-15 pubmed publisher
Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers T, et al. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012;119:6162-71 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
2926-BP
SKU :
2926-BP-025
product name :
Recombinant Human BMP-10 Protein
description :
The Recombinant Human BMP-10 Protein from R&D Systems is derived from CHO. The Recombinant Human BMP-10 Protein has been validated for the following applications: Bioactivity.
target :
BMP-10
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
13 kDa, reducing conditions
theoretical molecular weight :
12.2 kDa (monomer)
gene symbol :
BMP10
details of functionality :
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 15-60 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O95393
applications :
Bioactivity
product keywords :
2926-BP, rhBMP-10, hBMP-10,, 2926BP, cytokinegrowthfact, BMP10, BMP 10, cytokine, cytokines
source :
CHO-derived Recombinant Human BMP-10 Protein
USD :
567
USD 2025 :
573 USD
alt names :
BMP10, BMP-10, bone morphogenetic protein 10, MGC126783
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.