This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IGF-II/IGF2 Protein, CF
catalog :
292-G2
quantity :
50 ug (also 250 ug)
price :
179 USD
citations: 36
Reference
Mercurio L, Lulli D, Mascia F, Dellambra E, Scarponi C, Morelli M, et al. Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21. Aging (Albany NY). 2020;12:6823-6851 pubmed publisher
Garrett S, Hsu E, Thomas J, Pilewski J, Feghali Bostwick C. Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. PLoS ONE. 2019;14:e0225422 pubmed publisher
Conover C, Bale L, Frye R, Schaff H. Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes. Physiol Rep. 2019;7:e14006 pubmed publisher
De Giovanni C, Nanni P, Landuzzi L, Ianzano M, Nicoletti G, Croci S, et al. Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis. BMC Cancer. 2019;19:126 pubmed publisher
Chen Z, Liu J, Chu D, Shan Y, Ma G, Zhang H, et al. A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. Int J Biol Sci. 2018;14:799-806 pubmed publisher
Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, et al. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018;13:e0197046 pubmed publisher
Jalili R, Horecka J, Swartz J, Davis R, Persson H. Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies. Proc Natl Acad Sci U S A. 2018;115:E925-E933 pubmed publisher
Guan S, Lam A, Newman J, Chua K, Kok C, Chong S, et al. Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2/IGFBP2 complex. FEBS Open Bio. 2018;8:15-26 pubmed publisher
Liu Y, Yu C, Wu Y, Sun X, Su Q, You C, et al. CD44+ fibroblasts increases breast cancer cell survival and drug resistance via IGF2BP3-CD44-IGF2 signalling. J Cell Mol Med. 2017;21:1979-1988 pubmed publisher
Stratman A, Pezoa S, Farrelly O, Castranova D, Dye L, Butler M, et al. Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta. Development. 2017;144:115-127 pubmed publisher
Ungerleider N, Han C, Zhang J, Yao L, Wu T. TGFβ signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells. Mol Carcinog. 2017;56:1302-1311 pubmed publisher
Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, et al. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Oncogene. 2017;36:1276-1286 pubmed publisher
Cassinelli G, Favini E, Dal Bo L, Tortoreto M, De Maglie M, Dagrada G, et al. Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases. Oncotarget. 2016;7:47848-47863 pubmed publisher
Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez J, et al. Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Sci Rep. 2016;6:25960 pubmed publisher
Gomez D, O Driscoll M, Sheets T, Hruban R, Oberholzer J, McGarrigle J, et al. Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS ONE. 2015;10:e0133862 pubmed publisher
Shahmoradi A, Radyushkin K, Rossner M. Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A. 2015;112:E3582-9 pubmed publisher
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, et al. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest. 2015;125:1243-54 pubmed publisher
Crosley E, Dunk C, Beristain A, Christians J. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Reprod Biol Endocrinol. 2014;12:123 pubmed publisher
Bambah Mukku D, Travaglia A, Chen D, Pollonini G, Alberini C. A positive autoregulatory BDNF feedback loop via C/EBPβ mediates hippocampal memory consolidation. J Neurosci. 2014;34:12547-59 pubmed publisher
Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, et al. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. Br J Cancer. 2014;110:2865-73 pubmed publisher
Laggai S, Kessler S, Boettcher S, Lebrun V, Gemperlein K, Lederer E, et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res. 2014;55:1087-97 pubmed publisher
Yang G, Geng X, Song J, Wu Y, Yan H, Zhan Z, et al. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014;133:1702-8.e5 pubmed publisher
Cai Q, Bonfanti P, Sambathkumar R, Vanuytsel K, Vanhove J, Gysemans C, et al. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem Cells Transl Med. 2014;3:489-99 pubmed publisher
Kan S, Troitskaya L, Sinow C, Haitz K, Todd A, Di Stefano A, et al. Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts. Biochem J. 2014;458:281-9 pubmed publisher
Laranjeira A, de Vasconcellos J, Sodek L, Spago M, Fornazim M, Tone L, et al. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. Leukemia. 2012;26:1001-11 pubmed publisher
Guillon Munos A, Oikonomopoulou K, Michel N, Smith C, Petit Courty A, Canepa S, et al. Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors. J Biol Chem. 2011;286:25505-18 pubmed publisher
Fischer A, Scott M, Zelinka C, Sherwood P. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Müller glia. Glia. 2010;58:633-49 pubmed publisher
Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, et al. CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis. Exp Cell Res. 2009;315:3301-11 pubmed publisher
Ye L, Chang J, Lin C, Sun X, Yu J, Kan Y. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A. 2009;106:9826-30 pubmed publisher
Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, et al. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther. 2008;7:1483-93 pubmed publisher
Hsu E, Feghali Bostwick C. Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways. Am J Pathol. 2008;172:1580-90 pubmed publisher
Adkins R, Fain J, Krushkal J, Klauser C, Magann E, Morrison J. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. Pediatr Res. 2007;62:451-5 pubmed
Spicer L, Aad P. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod. 2007;77:18-27 pubmed
Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, et al. Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp Hematol. 2006;34:760-9 pubmed
McCaig C, Duval C, Hemers E, Steele I, Pritchard D, Przemeck S, et al. The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology. 2006;130:1754-63 pubmed
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, et al. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem Biophys Res Commun. 2005;333:1011-6 pubmed
product information
brand :
R&D Systems
master code :
292-G2
SKU :
292-G2-050
product name :
Recombinant Human IGF-II/IGF2 Protein, CF
description :
The Recombinant Human IGF-II/IGF2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IGF-II/IGF2 Protein, CF has been validated for the following applications: Bioactivity.
target :
IGF-II/IGF2
category :
Proteins and Enzymes
unit size :
50 ug (also 250 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetic Acid.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
7.5 kDa
gene symbol :
IGF2
details of functionality :
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 1.5-6 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
292-G2
accessionNumbers :
P01344.1
applications :
Bioactivity
source :
E. coli -derived human IGF-II/IGF2 protein Ala25-Glu91
2020 USD :
179
2021 USD :
179 USD
alt names :
C11orf43, chromosome 11 open reading frame 43, FLJ22066, FLJ44734, GRDF, IGF2, IGF-2, IGFII, IGF-II, insulin-like growth factor 2 (somatomedin A), insulin-like growth factor II, insulin-like growth factor type 2, MSA, PEG2, PP9974, somatomedin-A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.