Recombinant Human HTRA1 Protein, CF | R&D Systems 2916-SE-020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human HTRA1 Protein, CF

catalog :

2916-SE-020

quantity :

20 ug

price :

514 USD

citations: 5

Reference
Navneet S, Brandon C, Simpson K, Rohrer B. Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human. Cells. 2023;12: pubmed publisher
Sabino F, Madzharova E, auf dem Keller U. Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival. Cell Death Dis. 2020;11:674 pubmed publisher
Yamawaki S, Naitoh M, Kubota H, Aya R, Katayama Y, Ishiko T, et al. HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development. Int J Mol Sci. 2018;19: pubmed publisher
Chen J, Van Gulden S, McGuire T, Fleming A, Oka C, Kessler J, et al. BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018;38:3840-3857 pubmed publisher
Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, et al. The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis. J Immunol. 2014;193:130-8 pubmed publisher

product information

master code :

2916-SE

SKU :

2916-SE-020

product name :

Recombinant Human HTRA1 Protein, CF

unit size :

20 ug

description :

The Recombinant Human HTRA1 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human HTRA1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

HTRA1/PRSS11

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

37-40 kDa, reducing conditions

theoretical molecular weight :

36 kDa

gene symbol :

HTRA1

details of functionality :

Measured by its ability to cleave ▀-casein. 95% of ▀-Casein is cleaved by Recombinant Human HTRA1/PRSS11, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q92743

applications :

Enzyme Activity

source long :

E. coli -derived human HTRA1/PRSS11 protein Gly156-Pro480, with an N-terminal Met and C-terminal 6-His tag

source short :

E. coli

USD :

514 USD

alt names :

ARMD7, EC 3.4.21, EC 3.4.21.108, High-temperature requirement A serine peptidase 1, HtrA serine peptidase 1, IGFBP5-protease, L56, ORF480, PRSS11, Serine protease 11, serine, 11 (IGF binding)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.