Recombinant Human Lumican Protein, CF | R&D Systems 2846-LU product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Lumican Protein, CF

catalog :

2846-LU

quantity :

50 ug

price :

339 USD

citations: 7

Reference
Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez M, et al. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene. 2017;36:5432-5438 pubmed publisher
Karamanou K, Franchi M, Piperigkou Z, Perreau C, Maquart F, Vynios D, et al. Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition. Sci Rep. 2017;7:45138 pubmed publisher
Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, et al. Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clin Cancer Res. 2016;22:4934-4946 pubmed
Stasiak M, Boncela J, Perreau C, Karamanou K, Chatron Colliet A, Proult I, et al. Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity. PLoS ONE. 2016;11:e0150226 pubmed publisher
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G. Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2013;54:1014-25 pubmed publisher
Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, et al. Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest. 2012;92:1712-25 pubmed publisher
Seomun Y, Joo C. Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signaling. Biochem Biophys Res Commun. 2008;372:221-5 pubmed publisher

product information

brand :

R&D Systems

master code :

2846-LU

SKU :

2846-LU-050

product name :

Recombinant Human Lumican Protein, CF

description :

The Recombinant Human Lumican Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lumican Protein, CF has been validated for the following applications: Bioactivity.

target :

Lumican

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

55-65 kDa, reducing conditions

theoretical molecular weight :

37.5 kDa

gene symbol :

LUM

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of BCE C/D-1b bovine corneal endothelial cells. When 5 x 104 cells per well are added to Recombinant Human Lumican coated plates (10 µg/mL, 100 µL/well), 35% will adhere after 50 minutes at 37 °C. Optimal dilutions should be determined by each laboratory for each application. Also measured by its ability to modulate collagen fibrillogenesis.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

2846-LU

accessionNumbers :

P51884

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human Lumican protein Gln19-Asn338, with a C-terminal 6-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

KSPG lumican, LDC, LUM, lumican, lumican proteoglycan, SLRR2D, SLRR2DLDCKeratan sulfate proteoglycan lumican

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.