Recombinant Human Lumican Protein, CF | R&D Systems 2846-LU-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Lumican Protein, CF

catalog :

2846-LU-050

quantity :

50 ug

price :

432 USD

citations: 9

Reference
Karamanou K, Franchi M, Proult I, Rivet R, Vynios D, Br xe9 zillon S. Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers. Cells. 2021;10: pubmed publisher
Chen D, Smith L, Khandekar G, Patel P, Yu C, Zhang K, et al. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Sci Rep. 2020;10:19065 pubmed publisher
Asega A, Menezes M, Trevisan Silva D, Cajado Carvalho D, Bertholim L, Oliveira A, et al. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Sci Rep. 2020;10:12912 pubmed publisher
Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez M, et al. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene. 2017;36:5432-5438 pubmed publisher
Karamanou K, Franchi M, Piperigkou Z, Perreau C, Maquart F, Vynios D, et al. Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition. Sci Rep. 2017;7:45138 pubmed publisher
Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, et al. Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clin Cancer Res. 2016;22:4934-4946 pubmed
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G. Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2013;54:1014-25 pubmed publisher
Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, et al. Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest. 2012;92:1712-25 pubmed publisher
Seomun Y, Joo C. Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signaling. Biochem Biophys Res Commun. 2008;372:221-5 pubmed publisher

product information

master code :

2846-LU

SKU :

2846-LU-050

product name :

Recombinant Human Lumican Protein, CF

unit size :

50 ug

description :

The Recombinant Human Lumican Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lumican Protein, CF has been validated for the following applications: Bioactivity.

target :

Lumican

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

55-65 kDa, reducing conditions

theoretical molecular weight :

37.5 kDa

gene symbol :

LUM

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of BCE C/D-1b bovine corneal endothelial cells. When 5 x 104 cells per well are added to Recombinant Human Lumican coated plates (10 ╡g/mL, 100 ╡L/well), 35% will adhere after 50 minutes at 37 ░C. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P51884

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Lumican protein Gln19-Asn338, with a C-terminal 6-His tag

source short :

NS0

USD :

432 USD

alt names :

KSPG lumican, LDC, LUM, lumican, lumican proteoglycan, SLRR2D, SLRR2DLDCKeratan sulfate proteoglycan lumican

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.