Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF | R&D Systems 2840-A3-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF

catalog :

2840-A3-050

quantity :

50 ug

price :

573 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Boudko S, Konopka E, Kim W, Taga Y, Mizuno K, Springer T, et al. A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding. J Biol Chem. 2023;299:104901 pubmed publisher
Hunter E, Hamaia S, Kim P, Malcor J, Farndale R. The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation. Sci Rep. 2022;12:21601 pubmed publisher
Cegarra C, Cameron B, Chaves C, Dabdoubi T, Do T, Gen xea t B, et al. An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family. PLoS ONE. 2022;17:e0274667 pubmed publisher
Koh K, Cao Y, Mangos S, Tardi N, Dande R, Lee H, et al. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. J Clin Invest. 2019;129:1713-1726 pubmed publisher
Haidari M, Zhang W, Caivano A, Chen Z, Ganjehei L, Mortazavi A, et al. Integrin ?2?1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells. J Biol Chem. 2012;287:32981-92 pubmed

product information

brand :

R&D Systems

master code :

2840-A3

SKU :

2840-A3-050

product name :

Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF has been validated for the following applications: Binding Activity.

target :

Integrin alpha 3 beta 1/VLA-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris-Citrate and NaCl.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

150 kDa and 125 kDa, reducing conditions

theoretical molecular weight :

110.5 kDa (Integrin alpha 3), 82.3 kDa (Integrin ▀1)

gene symbol :

ITGA3

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Collagen IV at 10 ╡g/mL can bind rhIntegrin a3í▀1 with an apparent Kd 2 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P26006 (Integrin alpha 3) P05556 (Integrin ▀1)

applications :

Binding Activity

source :

CHO-derived Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF

USD :

573 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage