product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human CCL7/MCP-3 Protein, CF
catalog :
282-P3-010/CF
quantity :
10 ug (also 50 ug)
price :
256 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, et al. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. PLoS ONE. 2023;18:e0280590 pubmed publisher
Kaibori Y, Nagakubo D. CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines. Cancer Gene Ther. 2023;30:137-148 pubmed publisher
Lee K, Wilson G, Pingen M, Fukuoka A, Hansell C, Bartolini R, et al. Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism. PLoS Biol. 2019;17:e3000287 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Leick M, Catusse J, Follo M, Nibbs R, Hartmann T, Veelken H, et al. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology. 2010;129:536-46 pubmed publisher
Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
Nguyen A, Stebbins E, Henson M, O Young G, Choi S, Quon D, et al. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006;312:1909-23 pubmed
Yamamoto H, Nagata M, Sakamoto Y. CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann Allergy Asthma Immunol. 2005;94:292-300 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Wan Y, Jakway J, Qiu H, Shah H, Garlisi C, Tian F, et al. Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002;456:1-10 pubmed
product information
brand :
R&D Systems
master code :
282-P3/CF
SKU :
282-P3-010/CF
product name :
Recombinant Human CCL7/MCP-3 Protein, CF
unit size :
10 ug (also 50 ug)
seo description :
The Recombinant Human CCL7/MCP-3 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human CCL7/MCP-3 Protein, CF has been validated for the following applications: Bioactivity.
target :
CCL7/MCP-3/MARC
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
9 kDa
gene symbol :
CCL7
details of functionality :
Measured by its ability to chemoattract 2-day cultured human monocytes. Matsushima,áK. etáal . (1989) J.áExp. Med. 169 :1485. The ED50 for this effect is 0.02-0.08 ╡g/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A. The ED50 for this effect is 0.1-0.5 ╡g/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q7Z7Q8
applications :
Bioactivity
source :
E. coli-derived Recombinant Human CCL7/MCP-3 Protein, CF
USD :
256 USD
alt names :
C-C motif chemokine 7, chemokine (C-C motif) ligand 7, FIC, MARC, MCP-3, MCP3Monocyte chemotactic protein 3, MCP-3Small-inducible cytokine A7, MGC138465, Monocyte chemoattractant protein 3, NC28SCYA6, SCYA7MGC138463, small inducible cytokine A7 (monocyte chemotactic protein 3)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.