Recombinant Human CCL8/MCP-2 Protein | R&D Systems 281-CP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL8/MCP-2 Protein

catalog :

281-CP

quantity :

10 ug (also 50 ug)

price :

199 USD

citations: 7

Reference
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, et al. CCR8+FOXp3+ Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017;114:6086-6091 pubmed publisher
Sakumoto R, Hayashi K, Fujii S, Kanahara H, Hosoe M, Furusawa T, et al. Possible Roles of CC- and CXC-Chemokines in Regulating Bovine Endometrial Function during Early Pregnancy. Int J Mol Sci. 2017;18: pubmed publisher
Karta M, Wickert L, Curran C, Gavala M, Denlinger L, Gern J, et al. Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014;133:1227-1230.e4 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Nguyen A, Stebbins E, Henson M, O Young G, Choi S, Quon D, et al. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006;312:1909-23 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Tay S, McCormack A, Rose M. Effect of cognate human CD4+ T cell and endothelial cell interactions upon chemokine production. Transplantation. 2004;78:987-94 pubmed

product information

brand :

R&D Systems

master code :

281-CP

SKU :

281-CP-010

product name :

Recombinant Human CCL8/MCP-2 Protein

description :

The Recombinant Human CCL8/MCP-2 Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL8/MCP-2 Protein has been validated for the following applications: Bioactivity.

target :

CCL8/MCP-2

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

9 kDa

gene symbol :

CCL8

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 0.01-0.06 µg/mL. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 0.03-0.1 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

281-CP

accessionNumbers :

P80075.2

applications :

Bioactivity

source :

E. coli -derived human CCL8/MCP-2 protein Gln24-Pro99

2020 USD :

199

2021 USD :

199 USD

alt names :

C-C motif chemokine 8, chemokine (C-C motif) ligand 8, HC14, MCP2, MCP-2, member 8 (monocyte chemotactic protein 2), monocyte chemoattractant protein 2, SCYA10, small-inducible cytokine A8

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.