Recombinant Human CCL8/MCP-2 Protein | R&D Systems 281-CP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL8/MCP-2 Protein

catalog :

281-CP-010

quantity :

10 ug (also 50 ug)

price :

256 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, et al. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. PLoS ONE. 2023;18:e0280590 pubmed publisher
Lee J, Lee Y, Kim K, Kim D, Joo K, Shin S, et al. Chemokine (C-C Motif) Ligand 8 and Tubulo-Interstitial Injury in Chronic Kidney Disease. Cells. 2022;11: pubmed publisher
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, et al. CCR8+FOXp3+ Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017;114:6086-6091 pubmed publisher
Sakumoto R, Hayashi K, Fujii S, Kanahara H, Hosoe M, Furusawa T, et al. Possible Roles of CC- and CXC-Chemokines in Regulating Bovine Endometrial Function during Early Pregnancy. Int J Mol Sci. 2017;18: pubmed publisher
Karta M, Wickert L, Curran C, Gavala M, Denlinger L, Gern J, et al. Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014;133:1227-1230.e4 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Nguyen A, Stebbins E, Henson M, O Young G, Choi S, Quon D, et al. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006;312:1909-23 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Tay S, McCormack A, Rose M. Effect of cognate human CD4+ T cell and endothelial cell interactions upon chemokine production. Transplantation. 2004;78:987-94 pubmed

product information

brand :

R&D Systems

master code :

281-CP

SKU :

281-CP-010

product name :

Recombinant Human CCL8/MCP-2 Protein

unit size :

10 ug (also 50 ug)

seo description :

The Recombinant Human CCL8/MCP-2 Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL8/MCP-2 Protein has been validated for the following applications: Bioactivity.

target :

CCL8/MCP-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

9 kDa

gene symbol :

CCL8

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 0.01-0.06 ╡g/mL. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 0.03-0.1 ╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P80075.2

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CCL8/MCP-2 Protein

USD :

256 USD

alt names :

C-C motif chemokine 8, chemokine (C-C motif) ligand 8, HC14, MCP2, MCP-2, member 8 (monocyte chemotactic protein 2), monocyte chemoattractant protein 2, SCYA10, small-inducible cytokine A8

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage