product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse MFG-E8 Protein
catalog :
2805-MF-050
quantity :
50 ug
price :
432 USD
more info or order :
citations: 37
Reference
Ding P, Liu J, Meng Y, Wang H, Huang Y, Su G, et al. MFG-E8 facilitates heart repair through M1/M2 polarization after myocardial infarction by inhibiting CaMKII. Int Immunopharmacol. 2024;126:111216 pubmed publisher
Wu W, Wang J, Chen J, Lu J, Lao Y, Huang K, et al. MFG-E8 has guiding significance for the prognosis and treatment of sepsis. Sci Rep. 2022;12:20916 pubmed publisher
Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, et al. Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production. Cell Signal. 2022;98:110419 pubmed publisher
Geng R, Lin Y, Ji M, Chang Q, Li Z, Xu L, et al. MFG-E8 promotes tendon-bone healing by regualting macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction. J Orthop Translat. 2022;34:11-21 pubmed publisher
Brilland B, Laplante P, Thebault P, Geoffroy K, Brissette M, Latour M, et al. MFG-E8 Reduces Aortic Intimal Proliferation in a Murine Model of Transplant Vasculopathy. Int J Mol Sci. 2022;23: pubmed publisher
Ikemoto Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Toyoda M, Kanazawa N, et al. Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Aging Cell. 2022;21:e13536 pubmed publisher
Mao Y, Finnemann S. Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK. Cells. 2021;10: pubmed publisher
Chiang H, Chu P, Chen S, Lee T. MFG-E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose-Dependent Mediation of Actin Polymerization. J Am Heart Assoc. 2021;10:e020870 pubmed publisher
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, et al. MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway. Cell Death Dis. 2021;12:533 pubmed publisher
Bu H, Subramanian S, Geng H, Wang X, Liu F, Chou P, et al. MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice. Cells. 2021;10: pubmed publisher
Esposito N, Mazzoni F, Vargas J, Finnemann S. Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3. Invest Ophthalmol Vis Sci. 2021;62:7 pubmed publisher
Cai X, Li Y, Zheng X, Hu R, Li Y, Xiao L, et al. Propofol suppresses microglial phagocytosis through the downregulation of MFG-E8. J Neuroinflammation. 2021;18:18 pubmed publisher
Chiang H, Chu P, Lee T. MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells. J Biomed Sci. 2019;26:61 pubmed publisher
Li J, Xu X, Cai X, Weng Y, Wang Y, Shen Q, et al. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress. Oxid Med Cell Longev. 2019;2019:2601394 pubmed publisher
Brelstaff J, Tolkovsky A, Ghetti B, Goedert M, Spillantini M. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell Rep. 2018;24:1939-1948.e4 pubmed publisher
Kumawat A, Yu C, Mann E, Schridde A, Finnemann S, Mowat A. Expression and characterization of αvβ5 integrin on intestinal macrophages. Eur J Immunol. 2018;48:1181-1187 pubmed publisher
Michalski M, Seydel A, Siismets E, Zweifler L, Koh A, Sinder B, et al. Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. FASEB J. 2018;32:3730-3741 pubmed publisher
Wang Y, Luo G, Chen J, Jiang R, Zhu J, Hu N, et al. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions. Sci Rep. 2017;7:42642 pubmed publisher
Khalifeh Soltani A, Gupta D, Ha A, Iqbal J, Hussain M, Podolsky M, et al. Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity. JCI Insight. 2016;1:e87418 pubmed publisher
Nakai W, Yoshida T, Diez D, Miyatake Y, Nishibu T, Imawaka N, et al. A novel affinity-based method for the isolation of highly purified extracellular vesicles. Sci Rep. 2016;6:33935 pubmed publisher
Brissette M, Laplante P, Qi S, Latour M, Cailhier J. Milk fat globule epidermal growth factor-8 limits tissue damage through inflammasome modulation during renal injury. J Leukoc Biol. 2016;100:1135-1146 pubmed
Yamada K, Uchiyama A, Uehara A, Perera B, Ogino S, Yokoyama Y, et al. MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell-Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages. Cancer Res. 2016;76:4283-92 pubmed publisher
Das A, Ghatak S, Sinha M, Chaffee S, Ahmed N, Parinandi N, et al. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. J Immunol. 2016;196:5089-100 pubmed publisher
Cheyuo C, Aziz M, Yang W, Jacob A, Zhou M, Wang P. Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia. PLoS ONE. 2015;10:e0122833 pubmed publisher
Uchiyama A, Yamada K, Perera B, Ogino S, Yokoyama Y, Takeuchi Y, et al. Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury. J Invest Dermatol. 2015;135:1157-1165 pubmed publisher
Soki F, Koh A, Jones J, Kim Y, Dai J, Keller E, et al. Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. J Biol Chem. 2014;289:24560-72 pubmed publisher
Abe T, Shin J, Hosur K, Udey M, Chavakis T, Hajishengallis G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J Immunol. 2014;193:1383-91 pubmed publisher
Neniskyte U, Vilalta A, Brown G. Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett. 2014;588:2952-6 pubmed publisher
Uchiyama A, Yamada K, Ogino S, Yokoyama Y, Takeuchi Y, Udey M, et al. MFG-E8 regulates angiogenesis in cutaneous wound healing. Am J Pathol. 2014;184:1981-90 pubmed publisher
Wang X, Rodda L, Bannard O, Cyster J. Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol. 2014;192:4601-9 pubmed publisher
Li E, Noda M, Doi Y, Parajuli B, Kawanokuchi J, Sonobe Y, et al. The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid ? toxicity. J Neuroinflammation. 2012;9:148 pubmed publisher
Aziz M, Matsuda A, Yang W, Jacob A, Wang P. Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2. J Immunol. 2012;189:393-402 pubmed publisher
Brissette M, Lepage S, Lamonde A, Sirois I, Groleau J, Laurin L, et al. MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming. PLoS ONE. 2012;7:e36368 pubmed publisher
Aziz M, Jacob A, Matsuda A, Wu R, Zhou M, Dong W, et al. Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-? production in macrophages via STAT3-mediated SOCS3 activation. PLoS ONE. 2011;6:e27685 pubmed publisher
Matsuda A, Wu R, Jacob A, Komura H, Zhou M, Wang Z, et al. Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med. 2011;39:2039-47 pubmed publisher
Jinushi M, Sato M, Kanamoto A, Itoh A, Nagai S, Koyasu S, et al. Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. J Exp Med. 2009;206:1317-26 pubmed publisher
Fuller A, Van Eldik L. MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol. 2008;3:246-56 pubmed publisher
product information
brand :
R&D Systems
master code :
2805-MF
SKU :
2805-MF-050
product name :
Recombinant Mouse MFG-E8 Protein
unit size :
50 ug
seo description :
The Recombinant Mouse MFG-E8 Protein from R&D Systems is derived from NS0. The Recombinant Mouse MFG-E8 Protein has been validated for the following applications: Binding Activity.
target :
MFG-E8
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
64-72 kDa, reducing conditions
theoretical molecular weight :
49.8 kDa
gene symbol :
Mfge8
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of SVEC4-10 mouse vascular endothelial cells. The ED50 for this effect is 10-50 ng/mL.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P21956
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse MFG-E8 Protein
USD :
432 USD
alt names :
BA46, Breast epithelial antigen BA46, EDIL1, hP47, HsT19888, lactadherin, Lactahedrin, Medin, MFG1, MFGE8, MFG-E8, MFGM, Milk fat globule-EGF factor 8, milk fat globule-EGF factor 8 protein, O-acetyl disialoganglioside synthase, OAcGD3S, SED1, SPAG10, sperm associated antigen 10, sperm surface protein hP47
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.