Recombinant Human IL-1ra/IL-1F3 Protein | R&D Systems 280-RA product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-1ra/IL-1F3 Protein

catalog :

280-RA

quantity :

10 ug (also 50 ug)

price :

299 USD

citations: 44

Reference
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Stojkovic S, Kaun C, Basílio J, Rauscher S, Hell L, Krychtiuk K, et al. Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation. Sci Rep. 2016;6:25171 pubmed publisher
Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X, et al. Pro-Inflammatory Cytokine IL-1Î² Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma. PLoS ONE. 2015;10:e0132677 pubmed publisher
Larena M, Holmgren J, Lebens M, Terrinoni M, Lundgren A. Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling. J Immunol. 2015;194:3829-39 pubmed publisher
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human Î³Î´ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed publisher
Delaloye J, Filali Mouhim A, Cameron M, Haddad E, Harari A, Goulet J, et al. Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins. J Virol. 2015;89:3819-32 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Yan X, Jiang E, Weng H. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. J Neuroinflammation. 2015;12:222 pubmed publisher
Foucher E, Blanchard S, Preisser L, Descamps P, Ifrah N, Delneste Y, et al. IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1Î±. Eur J Immunol. 2015;45:1092-102 pubmed publisher
Lee J, Heur M. Interleukin-1?-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA. Mol Cell Biol. 2014;34:3535-45 pubmed publisher
Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, et al. Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis. J Thromb Haemost. 2014;12:948-57 pubmed publisher
Issafras H, Corbin J, Goldfine I, Roell M. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014;348:202-15 pubmed publisher
Suwara M, Green N, Borthwick L, Mann J, Mayer Barber K, Barron L, et al. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7:684-93 pubmed publisher
Valcarcel M, Carrascal T, Crende O, Vidal Vanaclocha F. IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors. J Invest Dermatol. 2014;134:470-480 pubmed publisher
Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, et al. Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis. PLoS ONE. 2013;8:e60914 pubmed publisher
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
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product information

brand :

R&D Systems

master code :

280-RA

SKU :

280-RA-010

product name :

Recombinant Human IL-1ra/IL-1F3 Protein

description :

The Recombinant Human IL-1ra/IL-1F3 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-1ra/IL-1F3 Protein has been validated for the following applications: Bioactivity.

target :

IL-1ra/IL-1F3/IL1RN

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

17 kDa

gene symbol :

IL1RN

details of functionality :

Measured by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. et al . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 272. The ED50 for this effect is 5-40 ng/mL in the presence of 50 pg/mL of rhIL-1 alpha .

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

280-RA

accessionNumbers :

P18510

applications :

Bioactivity

source :

E. coli -derived human IL-1ra/IL-1F3 protein

2020 USD :

299

2021 USD :

299 USD

alt names :

DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.