Recombinant Human IL-1ra/IL-1F3 Protein, CF | R&D Systems 280-RA-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-1ra/IL-1F3 Protein, CF

catalog :

280-RA-010/CF

quantity :

10 ug (also 50 ug)

price :

355 USD

more info or order :

R&D Systems product webpage

citations: 54

Reference
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Hook J, Cao M, Weng K, Kinnare N, Moreland J. Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4. J Immunol. 2020;204:671-681 pubmed publisher
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Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, et al. Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells. J Cell Mol Med. 2017;21:1373-1387 pubmed publisher
Li Y, Oosting M, Smeekens S, Jaeger M, Aguirre Gamboa R, Le K, et al. A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell. 2016;167:1099-1110.e14 pubmed publisher
Stojkovic S, Kaun C, Basílio J, Rauscher S, Hell L, Krychtiuk K, et al. Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation. Sci Rep. 2016;6:25171 pubmed publisher
Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X, et al. Pro-Inflammatory Cytokine IL-1Î² Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma. PLoS ONE. 2015;10:e0132677 pubmed publisher
Larena M, Holmgren J, Lebens M, Terrinoni M, Lundgren A. Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling. J Immunol. 2015;194:3829-39 pubmed publisher
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human Î³Î´ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed publisher
Delaloye J, Filali Mouhim A, Cameron M, Haddad E, Harari A, Goulet J, et al. Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins. J Virol. 2015;89:3819-32 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Yan X, Jiang E, Weng H. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. J Neuroinflammation. 2015;12:222 pubmed publisher
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Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, et al. Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis. J Thromb Haemost. 2014;12:948-57 pubmed publisher
Issafras H, Corbin J, Goldfine I, Roell M. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014;348:202-15 pubmed publisher
Suwara M, Green N, Borthwick L, Mann J, Mayer Barber K, Barron L, et al. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7:684-93 pubmed publisher
Valcarcel M, Carrascal T, Crende O, Vidal Vanaclocha F. IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors. J Invest Dermatol. 2014;134:470-480 pubmed publisher
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Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
Serelli Lee V, Ling K, Ho C, Yeong L, Lim G, Ho B, et al. Persistent Helicobacter pylori specific Th17 responses in patients with past H. pylori infection are associated with elevated gastric mucosal IL-1?. PLoS ONE. 2012;7:e39199 pubmed publisher
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product information

brand :

R&D Systems

master code :

280-RA/CF

SKU :

280-RA-010/CF

product name :

Recombinant Human IL-1ra/IL-1F3 Protein, CF

unit size :

10 ug (also 50 ug)

seo description :

The Recombinant Human IL-1ra/IL-1F3 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-1ra/IL-1F3 Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-1ra/IL-1F3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

17 kDa

gene symbol :

IL1RN

details of functionality :

Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 5-40 ng/mL in the presence of 50 pg/mL of rhIL-1 alpha .

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human IL-1ra/IL-1F3 Protein Bioactivity

accessionNumbers :

P18510

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-1ra/IL-1F3 Protein, CF

USD :

355 USD

alt names :

DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage