This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human CCL2/MCP-1 Protein
catalog :
279-MC
quantity :
10 ug (also 50 ug)
price :
199 USD
citations: 70
Reference
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Thiesen S, Janciauskiene S, Uronen Hansson H, Agace W, Hogerkorp C, Spee P, et al. CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease. J Leukoc Biol. 2014;95:531-41 pubmed publisher
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed publisher
Sukkurwala A, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M, et al. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ. 2014;21:59-68 pubmed publisher
Kundumani Sridharan V, Singh N, Kumar S, Gadepalli R, Rao G. Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall rem. J Biol Chem. 2013;288:22150-62 pubmed publisher
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Gibbings S, Elkins N, Fitzgerald H, Tiao J, Weyman M, Shibao G, et al. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}. J Biol Chem. 2011;286:961-75 pubmed publisher
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product information
brand :
R&D Systems
master code :
279-MC
SKU :
279-MC-010
product name :
Recombinant Human CCL2/MCP-1 Protein
description :
The Recombinant Human CCL2/MCP-1 Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL2/MCP-1 Protein has been validated for the following applications: Bioactivity.
target :
CCL2/JE/MCP-1
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
10 kDa, reducing conditions
theoretical molecular weight :
8.7 kDa
gene symbol :
CCL2
details of functionality :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A. The ED50 for this effect is 5-30 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
279-MC
accessionNumbers :
P13500.1
applications :
Bioactivity
source :
E. coli -derived human CCL2/JE/MCP-1 protein Gln24-Thr99
2020 USD :
199
2021 USD :
199 USD
alt names :
C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.